何亚文

姓名: 何亚文

职称: 特别研究员

E-Mail: yawenhe@sjtu.edu.cn

个人主页:

联系电话: 62932418

  • 个人简历:

    个人简介

    湖北黄梅人,1992年毕业于华中师范大学生物系;1995年于中国科学院华南植物研究所获植物生理学硕士学位;1995-1997年在中国科学院华南植物研究所工作,任助理研究员;1997年9月获新加坡政府奖学金,赴新加坡国立大学(National University of Singapore, NUS)留学,1999年9月获植物学硕士学位;1999年12月加入新加坡分子农业生物学院(Institute of Molecular Agrobiology),任Assistant Research Officer;2002年加入新加坡分子与细胞生物研究院(Institute of Molecular and Cell Biology, IMCB),任Junior Research Fellow,主要研究野油菜黄单胞菌和水稻白叶枯菌(Xanthomonas)群体感应(Quorum sensing)机理;2006年获NUS-IMCB联合培养理学博士学位(研究型),任分子与细胞生物研究院Research Fellow,从事黄单胞菌群体感应和低氧感应分子机理研究。2010年6月,加入上海交通大学生命科学技术学院,特别研究员,博导,微生物代谢国家重点实验室PI。

    教育经历

     

    2001.07-2006.10   新加坡分子与细胞生物学研究院   分子微生物学博士学位

    1997.09-1999.12   新加坡国立大学生物系           植物学硕士学位

    1992.09-1995.07   中科院华南植物研究所           植物生理学硕士学位

    1988.09-1992.09   华中师范大学生物系             生物学学士学位

    工作经历

     

     

    2010.06 -       上海交通大学生命科学技术学院 研究员 博导

    2006.10-2010.05 Institute of Molecular and Cell Biology (IMCB) Research Fellow

    2001.07-2006.09 IMCB Junior Research Fellow

    1999.12-2001.06 Institute of Molecular Agrobiology Assistant Research Officer

    1995.08-1997.08 中科院华南植物研究所    助理研究员


     

     

     

     

     

     

  • 1.         黄单胞菌群体感应机理及其基因表达调控网络

    2.         黄单胞菌与植物之间通过小分子信号互作的分子机制

    3.        植物根际促生菌功能基因组学和新型微生物源绿色农药研发

  • (1) Sun S, Chen B, Jin ZJ, Zhou L, Fang YL, Thawai C, Rampioni G, He Ya-Wen. Characterization of the multiple molecular mechanisms underlying RsaL control of phenazine-1-carboxylic acid biosynthesis in the rhizosphere bacterium Pseudomonas aeruginosa PA1201. Molecular Microbiology. 2017 Mar 18. doi: 10.1111/mmi.13671.

    (2) Zhou L, Wang X, Zhang W, Sun S, He Ya-Wen. Extraction, Purification and Quantification of Diffusible Signal Factor Family Quorum Sensing Signal Molecules in Xanthomonas oryzae pv. oryzae. Bio-protocol, 2017, 7(6): e2190.

    (3) Zhou L, Zhang LH, Cámara M, He YW. The DSF Family of Quorum Sensing Signals: Diversity, Biosynthesis, and Turnover. Trends in Microbiology. 2017, 25(4):293-303.

    (4) Sun S, Zhou L, Jin K, Jiang H, He Ya-Wen. Quorum sensing systems differentially regulate the production of phenazine-1-carboxylic acid in the rhizobacterium Pseudomonas aeruginosa PA1201. Sci Rep. 2016, 6:30352.

    (5) Wang Xing-Yu, Zhou Lian, Yang J, Ji Guang-Hai, He Ya-Wen. The RpfB-Dependent Quorum Sensing Signal Turnover System Is Required for Adaptation and Virulence in Rice Bacterial Blight Pathogen Xanthomonas oryzae pv. oryzae. Molecular Plant-Microbe Interactions. 2016, 29(3):220-30. 

    (6) Zhou Lian, Jiang Haixia, Sun Shuang, Yang Dandan, Jin Kaiming, He Ya-Wen. Biotechnological potential of a rhizosphere Pseudomonas aeruginosa strain producing phenazine-1-carboxylic acid and phenazine-1-carboxamide. World Journal of Microbiology and Biotechnology, 2016, 32(3):50.

    (7) Zhou Lian*, Wang Xing-Yu*, Sun Shuang, Yang Li-Chao, Jiang Bo-Le, He Ya-Wen. Identification and Characterization of Naturally Occurring DSF-Family Quorum Sensing Signal Turnover System in the Phytopathogen Xanthomonas. Environmental Microbiology, 2015, 17(11):4646–4658.

    (8)  Jin Kaiming*, Zhou Lian*, Jiang Haixia, Sun Shuang, Fang Yunling, Liu Jianhua, Zhang Xuehong, He Ya-Wen. Engineering the central biosynthetic and secondary metabolic pathways of Pseudomonas aeruginosa strain PA1201 to improve phenazine-1-carboxylic acid production. Metabolic Engineering, 2015, 32:30-38.

    (9) Wang Jia-Yuan*, Zhou Lian*, Chen Bo, Sun Shuang, Zhang Wei, Li Ming, Tang H, Jiang Bo-Le, Tang Jiang-Liang, He Ya-Wen. A functional 4-hydroxybenzoate degradation pathway in the phytopathogen Xanthomonas campestris is required for full pathogenicity. Scientific Reports, 2015, 5: 18456.

    (10)         Zhou Lian, Yu Yonghong, Chen Xiping, Diab AA, Ruan Lifang, He Jin, Wang Haihong#, He Ya-Wen#. The Multiple DSF-family QS Signals are synthesized from Carbohydrate and Branched-chain Amino Acids via the FAS Elongation Cycle. Scientific Reports, 2015, 5:13294.  

    (11)         Xu Shu, Pan X, Luo J, Wu J, Zhou Z, Liang X, He Ya-Wen, Zhou Mingguo. Effects of phenazine-1-carboxylic acid on the biology of the plant-pathogenic bacterium Xanthomonas oryzae pv. oryzae. Pesticide Biochemistry and Physiology, 2015, 117:39-46.

    (12)         Xu Jing, Zhou Lian, Venturi V, He Ya-Wen, Kojima M, Sakakibari H, Höfte M, De Vleesschauwer D. Phytohormone-mediated interkingdom signaling shapes the outcome of rice-Xanthomonas oryzae pv. oryzae interactions. BMC Plant Biology, 2015,15: 10.

    (13)         Zhou Lian*, Wang Jia-Yuan*, Wang Jianhe, Poplawsky A, Lin Shuangjun, Zhu Bangshang, Chang Changqing, Zhou Tieling, Zhang Lian-Hui#, He Ya-Wen#. The diffusible factor (DF) synthase XanB2 is a bifunctional chorismatase that links the shikimate pathway to ubiquinone and xanthomonadins biosynthetic pathways. Molecular Microbiology, 2013, 87(1): 80-93.

    (14)         Zhou Lian, Huang Tin-Wei, Sun Shuang, Wang Jia-Yuan, Chen Gongyou, Poplawsky AR, He Ya-Wen.  The rice acterial pathogen Xanthomonas oryzae pv. oryzae produces 3-hydroxybenzoic acid and 4-hydroxybenzoic acid via XanB2 for use in xanthomonadin, ubiquinone and exopolysaccharide biosynthesis. Molecular Plant-Microbe Interactions. 2013, 26(10):1239-48.

    (15)         Qian Guoliang, Wang Y, Liu Y, Xu F, He Ya-Wen, Du Liangcheng, Venturi V, Fan Jiaqing, Hu Boshi, Liu Fengquan. Lysobacter enzymogenes uses two distinct cell-cell signaling systems for differential regulation of secondary metabolite biosynthesis and colony morphology. Applied and Environmental Microbiology. 2013, 79(21): 6604-6616.

    (16)         Wu Da-Qiang, Ye Jing, Ou Hong-Yu, Wei Xue, Huang Xianqing, He Ya-Wen# and Xu Yuquan#. Genomic analysis and temperature-dependent transcriptome profiles of the rhizosphere originating strain Pseudomonas aeruginosa M18. BMC Genomics2011, 12438.

    (17)         Zhou Lian, Vorholter FJ, He Ying-Qiang, Jiang Bo-Le, Tang Ji-Liang, Xu Yuquan, Puhler A#, He Ya-Wen#. Gene discovery by genome-wide CDS re-prediction and microarray-based transcriptional analysis in phytopathogen Xanthomonas campestris. BMC Genomics, 2011, 12(1):359.

    (18)         He Ya-Wen#, Wu Jien, Zhou Lian, Yang Fan, Jiang Bo-Le, Tang Ji-Liang, Bai Linquan, Xu Yuquan, Deng Zixin, Zhang Lian-Hui#. Xanthomonas campestris diffusible factor is 3-hydroxybenzoic acid and associated with xanthomonadin biosynthesis, cell viability, antioxidant activity and systemic invasion. Molecular Plant-Microbe Interactions, 2011, 24(8):948-57.

    (19)         He Ya-Wen*, Wu JE, Cha JS, Zhang LH (2010) Rice bacterial blight pathogen Xanthomonas oryzae pv. oryzae produces multiple DSF-family signals in regulation of virulence factor production. BMC Microbiology, 10:187.

    (20)         Cheng Z*, He Ya-Wen*, Lim SC*, Qamra R*, Walsh MA, Zhang LH, Song H (2010) Structural Basis of the Sensor-Synthase Interaction in Autoinduction of the Quorum Sensing Signal DSF Biosynthesis. Structure, 18(9):1199-1209.

    (21)         Tao F, He Ya-Wen, Wu DH, Swarup S, Zhang LH (2010) The cyclic nucleotide monophosphate domain of Xanthomonas campestris global regulator Clp defines a new class of cyclic di-GMP effectors. The Journal of Bacteriology, 192(4):1020-9.

    (22)         He Ya-Wen, Boon C, Zhou L,  Zhang LH (2009) Co-regulation of Xanthomonas campestris virulence by quorum sensing and a novel two-component regulatory system RavS/RavR. Molecular Microbiology, 71(6):1464-1476.

    (23)         He Ya-Wen, Zhang LH (2008) Quorum Sensing and Virulence Regulation in Xanthomonas campestris. FEMS Microbiology Reviews, 32: 842-857.

    (24)         Boon C, Deng Y, Wang LH, He Ya-Wen, Xu JL, Fan Y, Pan SQ, Zhang LH (2008) A novel DSF-like signal from Burkholderia cenocepacia interferes with Candida albicans morphological transition. International Society of Microbial Ecology Journal (ISMEJ), 2(1):27-36.

    (25)         He Ya-Wen, Ng YJ, Xu M, Lin K and Zhang LH (2007) Xanthomonas campestris cell-cell communication involves a nucleotide receptor protein Clp and a hierarchical signaling network. Molecular Microbiology, 64(2):281-292.

    (26)         He Ya-Wen, Wang C, Zhou L, Song H, Dow JM, Zhang LH (2006) Dual signaling functions of the hybrid sensor kinase RpfC of Xanthomonas campestris involve either phosphorelay or receiver domain-protein interaction.  The Journal of Biological Chemistry, 281:33414 – 33421.

    (27)         Ryan RP, Fouhy Y, Lucey JF, Crossman LC, Spiro S, He Ya-Wen, Zhang LH, Heeb S, Camara M, Williams P, Dow JM (2006) Cell-cell signaling in Xanthomonas campestris  involves  an  HD-GYP  domain  protein  that  functions  in cyclic di-GMP turnover.  Proceedings of National Academy of Science of USA, 103(17):6712-6717.

    (28)         He Ya-Wen, Xu M, Lin K, Ng YJ, Wen CM, Wang LH, Liu ZD, Zhang HB, Dong YH, Dow JM and Zhang LH (2006) Genome scale analysis of diffusible signal factor regulon in Xanthomonas campestris pv. campestris: identification of novel cell-cell communication-dependent genes and functions.  Molecular Microbiology, 59(2):610-622.

    (29)         Wang LH, He Ya-Wen, Gao YF, Wu JE, Dong YH, Wang RB, He CZ, Wang SX, Weng LX, Xu JL, Tay L, Fang RX, Zhang LH (2004) A bacterial cell-cell communication signal with cross-kingdom structural analogs.  Molecular Microbiology, 51(3):903-12.

    (30)         Lo J, Lee S, Xu M, Liu F, Ruan H, Eun A, He Ya-Wen, Ma W, Wang W, Wen Z, Peng J (2003) 15,000 unique zebrafish est clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome Research, 13: 455-466.  

    (31)         Lee S, Cheng H, King KE, Wang W, He Ya-Wen, Hussain A, Lo J, Harberd NP, Peng J (2002) Gibberellin regulates Arabidopsis seed germination via RGL2, a GAI/RGA-like gene whose expression is up-regulated following imbibition. Genes and Development, 16:646-658.                                                                          

    (32)         He Ya-Wen and Loh CS (2002) Induction of early bolting in Arabidopsis thaliana by triacontanol, cerium and lanthanum is correlated with increased endogenous concentration of isopentenyl adenosine (iPAdos). Journal of Experimental Botany, 53 (368):505-512.                    

    (33)         He Ya-Wen and Loh CS (2000) Cerium and lanthanum promote floral initiation and reproductive growth of Arabidopsis thaliana. Plant Science, 159:117-124.