吴 更

姓名: 吴 更

职称: 研究员

E-Mail: Geng.wu@sjtu.edu.cn

个人主页:

联系电话: 021-34205914

  • 个人简历:

     个人简介

    1997年在中国科学技术大学生物系获学士学位,2001年在普林斯顿大学化学系获博士学位。发表SCI论文28篇,被引用超过1500次。曾分别在NatureMolecular CellScience上发表第一作者论文,已分别被引用464次、281次和152次。所解析的Smac-XIAP蛋白质复合物的晶体结构被GenentechNovartis等制药公司作为研发抗癌药物的参考依据,研发出的某些化合物已用于临床实验。2008年开始在上海交大担任教授、博士生导师,作为独立PI建立了上海交大第一个、也是目前上海交大闵行校区唯一一个结构生物学实验室。以通讯作者身份在Cell ResearchMolecular MicrobiologySCI期刊上发表8篇论文。获上海市“东方学者”特聘教授(2008)、上海市“曙光学者”(2008)、上海市“浦江人才”(2009)、教育部“新世纪优秀人才”(2009)等荣誉。

    教育经历

    1999.5 2001.5  普林斯顿大学(美国) 化学系  博士

    1997.8 1999.5  普林斯顿大学(美国) 化学系  硕士

    1992.9 1997.7  中国科学技术大学     生物系  学士

    工作经历

    2008.6–现在 上海交通大学生命科学技术学院  教授、博士生导师

    2003.62008.6   哈佛大学医学院/波士顿儿童医院(美国) 博士后

    2001.62003.6   Memorial Sloan Kettering癌症研究所/Howard Hughes Medical Institute(美国) 博士后

    荣誉奖励

    上海市“东方学者”特聘教授(2008

    上海市“曙光学者”(2008

    上海市“浦江人才计划”(2009

    教育部“新世纪优秀人才”(2009

  • 1. 细菌合成代谢与分解代谢中重要酶的底物识别与反应催化机理探索

    2. 与癌症等人类疾病相关的细胞信号传导通路中重要蛋白质复合物的结构与功能研究

  • 1.  Li A, Zhang Y*, Wang C, Wu G*, Wang Z. Purification, molecular cloning, and antimicrobial activity of peptides from the skin secretion of the black-spotted frog,Rana nigromaculataWorld J Microbiol Biotechnol, 2013, Apr 30 [Epub ahead of print].

    2. Chen D, Tang H, Lv Y, Zhang Z, Shen K, Lin K, Zhao YL, Wu G*, Xu P*. Structural and computational studies of the maleate isomerase from Pseudomonas putidaS16 reveal a breathing motion wrapping the substrate inside. Mol Microbiol, 2013, 87(6):1237-1244.

    3 Zhang Z#, Chen L#, Gao L#, Lin K#*, Zhu L, Lu Y, Shi X, Gao Y, Zhou J, Xu P, Zhang J*, Wu G*. Structural basis for the recognition of Asef by Adenomatous Polyposis Coli. Cell Res, 2012, 22(2):372-386. (被英国皇家科学院院士Mariann Bienz选入国际生物医药类论文权威数据库Faculty of 1000)

    4. Chen F#, Zhang Z#, Lin L#*, Qian T, Zhang Y, You D, He X, Wang Z, Liang J, Deng Z, Wu G*. Crystal structure of the cysteine desulfurase DndA ofStreptomyces lividans which is involved in DNA phosphorothioation. PLoS One, 2012, 7(5):e36635.

    5. Hu W, Wang C, Liang J, Zhang T, Hu Z, Wang Z, Lan W, Li F, Wu H, Ding J, Wu G, Deng Z, Cao C*. Structural insights into DndE from Escherichia coli B7Ainvolved in DNA phosphorothioation modification. Cell Res, 2012, 22(7):1203-1206.

    6. Tang H, Yao Y, Wang L, Yu H, Ren Y, Wu G, Xu P*. Genomic analysis ofPseudomonas putida: genes in a genome island are crucial for nicotine degradation. Sci Rep, 2012, 2:377.

    7.  Tang H, Yu H, Tai C, Huang K, Liu Y, Wang L, Yao Y, Wu G, Xu P*. Genome sequence of a novel nicotine-degrading strain, Pseudomonas geniculata N1. J Bacteriol, 2012, 194(13):3553-3554.

    8. Li Q, Feng J, Gao C, Li F, Yu C, Meng L, Zhang Z, Ma C*, Gu L*, Wu G, Xu P. Purification and characterization of a flavin reductase from the biodesulfurizing bacterium Mycobacterium goodii X7B. Process Biochem, 2012, 47:1144-1149.

    9. Zhang Z#, Li H#, Chen L, Lu X, Zhang J, Xu P, Lin K#*, Wu G*. Molecular basis for the recognition of Adenomatous Polyposis Coli by the Discs Large 1 protein.PLoS One, 2011, 6(8):e23507.

    10. Zhang Z#, Lin K#*, Gao L#, Chen L#, Shi X, Wu G*. Crystal structure of the armadillo repeat domain of adenomatous polyposis coli which reveals its inherent flexibility. Biochem Biophys Res Commun, 2011, 412(4):732-736.

    11. Chen F#, Lin K#*, Zhang Z, Chen L, Shi X, Cao C, Wang Z, Liang J, Deng Z, Wu G*. Purification, crystallization, and preliminary X-ray analysis of DndE protein from Salmonella enterica serovar Cerro 87 which is involved in DNA phosphorothioation. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011, 67(Pt 11):1440-2.

    12. Huang Z#, Zhu L#, Cao Y, Wu G, Liu X, Chen Y, Wang Q, Shi T, Zhao Y, Wang Y, Li W, Li Y, Chen H*, Chen G, Zhang J*. ASD: a comprehensive database of allosteric proteins and modulators. Nucleic Acids Res, 2011, 39(Database issue):D663-9.

    13. Tao F, Zhao P, Li Q, Su F, Yu B, Ma C, Tang H, Tai C, Wu G, Xu P*. Genome sequence of Rhodococcus erythropolis XP, a biodesufurizing bacterium with industrial potential. J Bacteriol, 2011, 193(22):6422-6423.

    14. Gai Z, Wang X, Tang H, Tai C, Tao F, Wu G, Xu P*. Genome sequence ofSphingobium yanoikuyae XLDN2-5, an efficient carbazole-degrading strain. J Bacteriol, 2011, 193(22):6404-6405.

    15. Su F, Hua D, Zhang Z, Wang X, Tang H, Tao F, Tai C, Wu Q, Wu G, Xu P*. Genome sequence of Bacillus pumilus S-1, an efficient isoeugenol-utilizing producer for natural vanillin. J Bacteriol, 2011, 193(22):6400-6401.

    16. Yu H, Tang H, Wang L, Yao Y, Wu G, Xu P*. Complete genome sequence of nicotine-degrading Pseudomonas putida strain S16. J Bacteriol, 2011, 193(19):5541-5542.

    17. Gai Z, Wang X, Liu X, Tai C, Tang H, He X, Wu G, Deng Z, Xu P*. The genes coding for the conversion of carbazole to catechol are flanked by IS6100 elements in Sphingomonas sp. strain XLDN2-5. PLoS One, 2010, 5(4):e10018.

    18. Wu G*, Huang H, Abreu JG, He X*. Inhibition of GSK3 phosphorylation of β-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6. PLoS One, 2009,4(3):e4926.

    19. Li J, Feng J, Li Q, Ma C, Yu B, Gao C, Wu G, Xu P*. Both FMNH2 and FADH2 can be utilized by the dibenzothiophene monooxygenase from a desulfurizing bacterium Mycobacterium goodii X7B. Bioresour Technol, 2009, 100(9):2594-9.

    20. Tang H, Wang L, Meng X, Ma L, Wang S, He X, Wu G, Xu P*. Novel nicotine oxidoreductase-encoding gene involved in nicotine degradation by Pseudomonas putida strain S16. Appl Environ Microbiol, 2009, 75(3):772-8.

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