微生物代谢国家重点实验室-科研队伍

周虎臣

姓名: 周虎臣

职称: 研究员

E-Mail: hczhou@sjtu.edu.cn

个人主页:

联系电话: 34206721

个人简历:

个人简介

周虎臣，女，研究员，博士生导师。复旦大学化学系学士。普林斯顿(Princeton)大学化学系博士。于耶鲁 (Yale) 大学化学系进行博士后研究。并在美国Anacor制药公司任药物化学研发科学家。2007年加入上海交通大学，近年来主要从事药物化学，计算机辅助药物设计和化学生物学研究。目前研究重点主要是以分子识别为基础的小分子设计及其用于生物体系的调节和机理揭示。获上海市“浦江人才”、“曙光学者”和教育部“新世纪优秀人才计划”支持，同时承担国家自然科学基金优秀青年基金，并作为学术骨干参与国家重大科学研究计划(973)两项。并任上海高校E-化学生物学研究院特聘研究员和上海市药学会药物化学专业委员会委员。

教育经历

1998-2003 普林斯顿大学化学系   博士学位

1992-1997 复旦大学化学系       学士学位

工作经历

2007-至今上海交通大学药学院    研究员

2005-2007 Anacor Pharmaceuticals   研发科学家

2003-2005 耶鲁大学化学系        博士后

荣誉奖励

2012 国家自然科学基金“优秀青年基金”

2011 上海市药学会药物化学专业委员会委员

2009 上海高校E-化学生物学研究院特聘研究员

2008 教育部“新世纪优秀人才计划”

2007 上海科委“浦江人才”计划

2007 上海教委“曙光学者”
以分子识别为基础的小分子设计及对生物体系的调节和机理揭示：

1. 以发现原创药物为目标的药物化学研究和计算机辅助药物设计

2. 用于揭示疾病和药物的生物机制的小分子探针的设计和研究
1.       Zhao Y, Zhou F, Zhou H*, Su H*. The structural and bonding evolution in cysteine-gold cluster complexes. Phys Chem Chem Phys, 2013, 15(5):1690-8.

2.       He H, Liao D, Wang Z, Wang Z, Zhou H*, Wang M, Ye R. Functional characterization of three mouse formyl peptide receptors. Mol Pharmacol, 2013, 83(2):389-98.

3.       Friesland A, Zhao Y, Chen Y, Wang L, Zhou H*, Lu Q*. Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc Natl Acad Sci U S A, 2013, 110(4):1261-6.

4.       Liu C, Zhou H*, Yin Q, Wu Y, Chen G. Targeting peroxiredoxins against leukemia. Exp Cell Res, 2013, 319(2):170-6.

5.       Liu C,^† Yin Q,^† Zhou H^† , Wu Y, Pu J, Xia L, Liu W, Huang X, Jiang T, Wu M, He L, Zhao Y, Wang X, Xiao W, Chen H, Zhao Q, Zhou A, Wang L, Sun H, Chen G. Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells.Nature Chem Biol, 2012, 8(5):486-93.

6.       Qiao Z, Wang Q, Zhang F, Wang Z, Bowling T, Nare B, Jacobs RT, Zhang J, Ding D, Liu, Y, Zhou H*. Chalcone-benzoxaborole hybrid molecules as potent antitrypanosomal agents. J Med Chem, 2012, 55(7):3553-7.

7.       Zhao Y, Wang Q, Meng Q, Ding D, Yang H, Gao G, Li D, Zhu W, Zhou H*. Identification of Trypanosoma brucei leucyl-tRNA synthetase inhibitors by pharmacophore- and docking-based virtual screening and synthesis. Bioorg Med Chem, 2012, 20(3):1240-1250.

8.       Zhang Y, Plattner J, Freund Y, Easom E, Zhou Y, Ye L, Zhou H*, Waterson D, Gamo F, Sanz L, Ge M, Li Z, Li L, Wang H, Cui H. Benzoxaborole antimalarial agents. 2. Discovery of fluoro-substituted 7-(2-carbozyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles. Bioorg Med Chem Lett, 2012, 22(3):1299-1307.

9.       Wu M, Meng Q, Ge M, Bai L, Zhou H*. 2,3,6-Trideoxy sugar nucleotides: synthesis and stability. Tetrahedron Lett, 2011, 52(44):5799-5801.

10.   Qiao Z, Wang W, Wang L, Wen D, Zhao Y, Wang Q, Meng Q, Chen G, Wu Y,*Zhou H*. Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors. Bioorg Med Chem Lett, 2011, 21(21):6389-6392.

11.   Wu P, Meng Q, Zhou H*. Synthesis of novel pyrrolo-benzoxaborole scaffold and its derivatization via Friedel-Crafts reaction catalyzed by anhydrous stannic chloride. Chin Chem Lett, 2011, 22(12):1411-1414.

12.   Ding D, Meng Q, Gao G, Zhao Y, Wang Q, Nare B, Jacobs R, Rock F, Alley MRK, Plattner JJ, Chen G, Li D, Zhou H* .Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents. J MedChem, 2011, 54(5):1276-1287.

13.   Gu Z, Liu C, Wu S, Zhao M, Xu H, Liu W, Zhou H*, Chen G, Wu Y. PU.1 directly regulates retinoic acid-induced expression of RIG-G in leukemia cells. FEBS Lett,2011, 585(2):375-380.

14.   Ding D, Zhao Y, Meng Q, Xie D, Nare B, Chen D, Bacchi CJ, Yarlett N, Zhang YK, Hernandez V, Xia Y, Freund Y, Abdulla M, Ang KH, Ratnam J, McKerrow JH, Jacobs RT, Zhou H*, Plattner JJ. Discovery of novel benzoxaborole-based potent antitrypanosomal agents. ACS Med Chem Lett, 2010, 1(4):165-169.

15.   Ye L, Ding D, Feng Y, Xie D, Wu P, Guo H, Meng Q, Zhou H*. Convenient and versatile synthesis of formyl-substituted benzoxaboroles. Tetrahedron, 2009, 65(42):8738-8744.

16.   Lu Q, Longo FM, Zhou H*, Massa SM, Chen Y. Signaling through Rho GTPase pathway as viable drug target. Curr Med Chem, 2009, 16(11):1355-1365.

17.   Chen W, Huang T, He X, Meng Q, You D, Bai L, Li J, Wu M, Li R, Xie Z, Zhou H*, Zhou X, Tan H, Deng Z. Charaterization of the polyoxin biosynthesis gene cluster from Streptomyces cacaoi and engineered production of polyoxin H. J Biol Chem, 2009, 284(16):10627-10638.

18.   Zhou Y, Meng Q, You D, Li J, Chen S, Ding D, Zhou X, Zhou H*, Bai L*, Deng Z. Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in streptomyces sp. strain FR-008. Appl Environ Microbiol, 2008, 74(23):7235-7242.

19.   Rock FL, Mao W, Yaremchuk A, Tukalo M, Crepin T, Zhou H*, Zhang YK, Hernandez V, Akama T, Baker SJ, Plattner JJ, Shapiro L, Martinis SA, Benkovic SJ, Cusack S, Alley MRK. An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science, 2007, 316(5832):1759-61.

20.   Zhou H, Baldini L, Hong J, Wilson AJ, Hamilton AD. Pattern-recognition of proteins based on an array of functionalized porphyrins. J AmChem Soc, 2006, 128(7):2421-5.