魏冬青

姓名: 魏冬青

职称: 教授

E-Mail: dqwei@sjtu.edu.cn

个人主页: http://tacc2008.sjtu.edu.cn/

联系电话: 021-34204573

  • 个人简历:

     

    个人简介

    开发了分子模拟软件SAMM,构建了细胞色素P450酶多态性基因型-表型相关性数据库。对CYP450酶进行了系统研究,发展了代谢网络以及统计预测模型和基于web的软件工具并应用到小分子代谢构效关系,代谢动力学和基因表型相关性的研究中。同时在跨膜蛋白质通道分子调控机制,阳离子跨膜机制的研究中取得一系列重要进展,成果发表在JACS等期刊。至今发表SCI文章150多篇, 编写专著8本,15篇邀请评述文章,参与13篇专著的有关章节编写。这些工作为国际同行所广泛引用和正面评述,经SCI检索,经SCI检索,已累积引用超过3300次,最高单篇引用210次,H因子为36。作为大会主席主持召开多个国际会议,50多次国际会议上做邀请和大会报告。           

    教育经历

    1987-1990  加拿大不列颠哥伦比亚大学  博士后

    1985-1987  美属波多黎各大学          博士学位

    1978-1985  河南师范大学学士          硕士学位

    工作经历

    2006-      上海交通大学生命学院生物信息与生物统计系教授,博士生导师,副主任

    2003-2006  天津市及天津师大特聘教授(海河学者)

    1999-2000  北京大学教授

    1993-2006  加拿大麦吉尔大学/计算及其应用研究中心研究员

    1990-1992  加拿大不列颠哥伦比亚大学研究学者

    荣誉奖励

    上海交大横山亮次优秀论文奖,中国交叉科学协会第五届焦善庆MMPH 研究奖

    曾任天津市特聘教授(海河学者)

    国际交叉科学学会会长,Springer期刊“Interdisciplinary Sciences Computational Life Sciences”主编,“J. Atomic and Molecular Sciences Managing Editor, Molecular Simulation”, J. Mol. Modeling and Graphics,10多家杂志编委。

  •  1. 结构生物信息学

    2. 生物统计学

    3. 计算生物物理学

  • 1.      Tang MP, Wang ZX,  Zhou Y, Xu WJ, Li ST, Wang LYWei DQ*Qiao ZD*. A novel drug candidate for Alzheimer's disease treatment: gx-50 derived fromZanthoxylum bungeanumJ Alzheimer’s Disease, 2013, 34(1):203–213.

    2.       Chen SG, Gu RX WeiDQ*Virtual Screening with Respect to alpha7 Nicotinic Acetylcholine Receptor for Possible Leads against Alzheimer's diseaseJournal of Molecular Graphics and Modeling, 201339:98-107

    3.      Wang Y, Wu XL*, Wei DQ*, Wang JF*, Li YX. Autoinhibitory mechanism for the mutation-induced impaired FGF9 signaling.J Chem Info Modeling, 2012, 52(9):2422-9.

    4.      Zhang T, Zhao MZ, Pang YS, Zhang W, Liu LA*, Wei DQ*Recent progress on bioinformatics, functional genomics, and metabolomics research of cytochrome P450 and its impact on drug discovery.Curr Top Med Chem. 2012, 12(12):1346-55.

    5.       Li L, Chen Q, Wei DQ*Prediction and functional analysis of single nucleotide polymorphisms.Curr Drug Metab, 2012, 13(7):1012-23.

    6.       Gu RX, Liu LA*, Wei DQ*Free energy calculations on the two drug binding sites in the M2 proton channel.J Am Chemr Soc, 2011, 133(28):10817–10825.

    7.       Arias HR, Gu RX, Feuerbach D, Guo BB, Ye Y, Wei DQ*Novel positive allosteric modulators of the human α7 nicotinic acetylcholine receptor.Biochemistry, 2011, 50(23):5263–5278.

    8.       Zhang T, Liu L*, Lewis D,  Wei DQ*Long-range effects of a surface mutation on the enzymatic activity of cytochrome P450 1A2. J Chem Info Model, 2011, 51(6):1336–1346.

    9.       Li J, Wei DQ*, Wang JF*, Li YX. A negative cooperativity mechanism of human CYP2E1 inferred from molecular dynamics simulations and free energy calculations.J Chem Info Model, 2011, 51(12):3217–3225.

    10.     Chen Q, Zhang T, Wang JF*, Wei DQ*Advances in human cytochrome p450 and personalized medicine.Curr Drug Metab, 2011, 12(5):436-44.

    11.    Gu RX, Zhong YQ, Wei DQ*. Structural basis of agonist selectivity for different nAChR subtypes: insights from crystal structures, mutation experiments and molecular simulations. Curr Pharm Des, 2011, 17(17):1652-1662.

    12.     Lian P, Wei DQ*, Wang JF*, Chou KC. An allosteric mechanism inferred from molecular dynamics simulations on phospholamban pentamer in lipid membranes. PLoS ONE, 2011, 6(4):e18587

    13.     Chang J, Lian P, Wei DQ*, Chen XR, Gong ZZ, Zhang QM. Thermal decomposition of the solid phase of nitromethane: ab initio molecular dynamics simulations. Phys Rev Lett2010, 105(18):188302-188305.

    14.     Wang Y, Wei DQ*, Wang JF*.Molecular dynamics studies on T1 lipase: insight into a double-flap mechanism. J Chem Inf Model, 2010, 50(5):875-8. 

    15.     Lian P, Liu LA, Shi YX*, Bu YX*, Wei DQ*Tethered-hopping model for protein-DNA binding and unbinding based on Sox2-Oct1-Hoxb1 ternary complex simulations. Biophys J, 2010, 98(7):1285-93

    16.     Arias HR*,Gu RX,  Feuerbach D, Wei DQ*Different interaction between the agonist JN403 and the competitive antagonist methyllycaconitine with the human alpha7 nicotinic acetylcholine receptor. Biochemistry, 201049(19):4169-4180.

    17.     Wang JF, Wei DQ*, Li YX*, Chou KC. Molecular dynamics studies on the interactions of PTP1B with inhibitors: from the first phosphate-binding site to the second one. Protein Eng Des Sel, 200922(6):349-55.  

    18.     Wang JF, Zhang CC, Yan JY, Chou KCWei DQ*Structure of cytochrome p450s and personalized drug. Curr Med Chem, 2009,16(2):232-44.

    19.     Wang JFWei DQ*, Chou KC*. Drug candidates from traditional chinese medicines. Curr Top Med Chem20088(18):1656-65.

    20.     Wang JFWei DQ*,Chou KC. Pharmacogenomics and personalized use of drugs. Curr Top Med Chem. 20088(18):1573-9.

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