周宁一

姓名: 周宁一

职称: 教授

E-Mail: ningyi.zhou@sjtu.edu.cn

个人主页:

联系电话: 021-34204135

  • 个人简历:

     

    个人简介
    上海交通大学特聘教授,生命科学技术学院微生物科学系系主任,微生物代谢国家重点实验室分子环境微生物研究组组长。2014-2016连续三年入选爱思唯尔(Elsevier)发布的中国高被引学者榜单(“免疫与微生物学”领域)

    教育经历 
    武汉大学微生物学专业学士 
    英国伦敦帝国理工学院(Imperial College London)微生物学专业博士学位, 
     

    工作经历 
    帝国理工学院和威尔士大学(University of Wales, Bangor)从事博士后研究。中国科学院武汉病毒研究所研究员,中国科学院农业与环境微生物重点实验室主任。

    荣誉奖励  
    中国科学院“百人计划”, 国务院政府特殊津贴, 中国科学院朱李月华优秀教师奖, 武汉市优秀科技工作者, 湖北省自然科学奖二等奖。

    学会兼职 
    中国微生物学会常务理事,中国微生物学会环境微生物学专业委员会主任委员,《微生物通报》副主编,Editor for Applied and Environmental Microbiology, Associate Editor for Frontiers in Microbiology

     

  • 1.微生物分解代谢芳烃的生物化学和分子生物学

    2.合成生物学在污染控制和生物修复的应用

  •  
    1. Gao YZ, Liu H, Chao HJ, and Zhou NY*. Constitutive expression of Nag-like dioxygenase gene through an internal promoter in the 2-chloronitrobenzene catabolic gene cluster of Pseudomonas stutzeri ZWLR2-1. Appl. Environ. Microbiol. 2016, 82:3461-3470.
    2. Min J, Zhang JJ, Zhou NY*.  A Two-Component para-nitrophenol monooxygenase initiates a novel 2-chloro-4-nitrophenol catabolism pathway in Rhodococcus imtechensis RKJ300. Appl. Environ. Microbiol. 2016, 82: 714-723.
    3. Chao HJ, Chen YF, Fang T, Xu Y, Huang WE, Zhou NY*. HipH catalyzes the hydroxylation of 4-hydroxyisophthalate to protocatechuate in 2, 4-xylenol catabolism by pseudomonas putida NCIMB 9866. Appl. Environ. Microbiol. 2016, 82: 724-731.
    4. Liu S, Su T, Zhang C, Zhang, WM, Zhu D, Su J, Wei T, Wang K, Huang Y, Guo L, Xu S, Zhou NY*, Gu L*. Crystal structure of PnpCD, a two-subunit hydroquinone 1, 2-dioxygenase, reveals a novel structural class of Fe2+-dependent dioxygenases. J Biol Chem, 2015, 290: 24547-24560.
    5. Liu K Xu Y, Zhou NY*. Identification of a specific maleate hydratase in the direct hydrolysis route of the gentisate pathway. Appl. Environ. Microbiol. 2015, 81: 5753-5760
    6. Zhang WM, Zhang JJ, Jiang X, Chao HJ, Zhou NY*. Transcriptional activation of multiple operons involved in para-nitrophenol degradation by Pseudomonas sp. strain WBC-3. Appl. Environ. Microbiol. 2015, 81: 220-230
    7. Min J, Zhang JJ, and Zhou NY*. The gene cluster for para-nitrophenol catabolism is responsible for 2-chloro-4-nitrophenol degradation in Burkholderia sp. strain SJ98. Appl. Environ. Microbiol. 2014, 80: 6212-6222
    8. Chao HJ, Zhou NY*. Involvement of the global regulator GlxR in 3-hydroxybenzoate and gentisate utilization by Corynebacterium glutamicum. Appl. Environ. Microbiol. 2014, 80:4215-4225
    9. Xu Y, Chen B, Chao HJ, Zhou NY*. 2013. mhpT encodes an active transporter involved in 3-(3-hydroxyphenyl)propionate catabolism by Escherichia coli K-12. Appl. Environ. Microbiol. 2013, 79: 6362-6368
    10. Sun DL, Jiang X, Wu QL, Zhou NY*. Intragenomic heterogeneity of 16S rRNA genes causes overestimation of prokaryotic diversity. Appl. Environ. Microbiol. 2013, 79:5962-5969
    11. Chao HJ, Zhou NY*. GenR, an IclR-type regulator, activates and represses the transcription of gen genes involved in 3-hydroxybenzoate and gentisate catabolism in Corynebacterium glutamicum. J. Bacteriol. 2013, 195: 1598-1609
    12. Liu K, Liu TT, Zhou NY*. HbzF catalyzes direct hydrolysis of maleylpyruvate in the gentisate pathway of Pseudomonas alcaligenes NCIMB 9867. Appl. Environ. Microbiol. 2013, 79: 1044-1047
    13. Chi XQ, Zhang JJ, Zhao S, Zhou NY*. Bioaugmentation with a consortium of bacterial nitrophenol-degraders for remediation of soil contaminated with three nitrophenol isomers. Environ. Pollut.2013, 172:33-41
    14. Liu TT , Zhou NY*. Novel L-cysteine dependent maleylpyruvate isomerase in the gentisate pathway of Paenibacillus sp. strain NyZ101. J. Bacteriol. 2012, 194:3987-3994
    15. Xiao Y, Liu TT, Dai H, Zhang JJ, Liu H, Tang H, Leak DJ, Zhou NY*. OnpA, an unusual flavin dependent monooxygenase containing a cytochrome b5 domain. J. Bacteriol. 2012, 194: 1342-1349
    16. Xu Y, Gao X, Wang SH, Liu H, Williams PA, Zhou NY*. MhbT is a specific transporter for 3-hydroxybenzoate uptake by Gram-negative bacteria. 2012, Appl. Environ. Microbiol. 78:6113-6120

  •  1. 揭示了微生物分解代谢单硝基酚三种同分异构体的机理(JB 189:6587, JB 191:2703, JB 194: 134), 2-氯-4-硝基酚的代谢(AEM 80: 6212, AEM 82: 714), 4-硝基酚代谢的转录调控(AEM 81: 220), 和2-氯硝基苯的分解代谢途径与相关基因表达的进化(AEM 77: 4547, AEM 82:3461);

    2. 发现了龙胆酸代谢途径中依赖于半胱氨酸的顺丁烯二酸单酰丙酮酸异构酶(JB 194:3987) , 顺丁烯二酸单酰丙酮酸水解酶(AEM 79: 1044) 和马来酸水合酶 (AEM 81: 5753),并揭示了龙胆酸代谢的调控机理(JB 195: 1598,AEM 80:4215);
    3. 发现并鉴定了微生物3-羟基苯甲酸(AEM 78:6113)和3-羟基苯丙酸(AEM 79: 6362)的转运蛋白;
    4. 利用代谢工程成功地构建了降解六氯苯[持久性有机污染物(POPs)之一]的工程菌(AEM 72:2283);
    5. 生物修复硝基苯(FEMS Microbiol. Ecol. 70:315),4-氯硝基苯(Environ. Pollut. 157:763)和单硝基酚三种同分异构体(Environ. Pollut.172:3)的污染土壤并揭示其相关分子生态学效应。