陶美凤

姓名: 陶美凤

职称: 研究员

E-Mail: Tao_meifeng@sjtu.edu.cn

个人主页: http://mml.sjtu.edu.cn/

联系电话: 021-62933765-2051

  • 个人简历:

    个人简介

    博士,研究员。1992年获武汉大学生物化学专业学士学位,1999年获华中农业大学生物化学与分子生物学博士学位。1999-2008年任教于华中农业大学,任讲师、副教授。1999-2001(每年6个月)赴英国约翰.英纳斯中心(John Innes Centre)Keith Chater教授实验室从事链霉菌分化及其调控机理研究;2005-2007年在美国威斯康星大学麦迪逊分校Ben Shen教授实验室,从事微生物天然产物的化学生物学研究。2009年入选教育部“新世纪优秀人才支持计划”。2009年任上海交通大学特别研究员。主要从事微生物次级代谢调控机理、新药资源挖掘研究工作。

    教育经历

    1994.09-1999.06  华中农业大学生命科技学院/农业微生物学国家重点实验室    博士

    1988.09-1992.06  武汉大学生物系生物化学专业    学士

    工作经历

    2009.01-   上海交通大学生命科学技术学院/微生物代谢国家重点实验室         研究员

    1999.07-2008.12    华中农业大学生命科技学院/农业微生物学国家重点实验室   讲师/副教授

    2005.03-2008.02    美国威斯康星大学-麦迪逊分校药学院   研究助理

    1999.07-2002.03    英国约翰×英纳斯中心  访问学者

    1992.07-1994.08    广西桂林市第二制药厂  技术员

    荣誉奖励

    2009, 教育部新世纪优秀人才计划

  • 1. 新抗生素及其基因簇资源的高通量挖掘

    2. 微生物新药高产的遗传机理与应用

    3. 天然产物生物合成

  • 1.Xu F, Kong D, He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S*. Characterization of streptonigrin biosynthesis reveals a cryptic carboxyl methylation and an unusual oxidative cleavage of a N-C bond. J Am Chem Soc, 2013, 135(5):1739-48.

    2.Huang SX, Feng Z, Wang L, Galm U, Wendt-Pienkowski E, Yang D, Tao M, Coughlin JM, Duan Y, Shen B*. A designer bleomycin with significantly improved DNA cleavage activity. J Am Chem Soc, 2012, 134(32):13501-9.

    3.Chen L, Wang Y, Guo H, Xu M, Deng Z, Tao M*. High-throughput screening forStreptomyces antibiotic biosynthesis activators. Appl Environ Microbiol, 2012, 78(12):4526-8.

    4.Zhou H, Wang Y, Yu Y, Bai T, Chen L, Liu P, Guo H, Zhu C, Tao M*, Deng Z. A non-restricting and non-methylating Escherichia coli strain for DNA cloning and high-throughput conjugation to Streptomyces coelicolorCurr Microbiol, 2012, 64(2):185-90.

    5.Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S*, Deng Z. Identification and characterization of the pyridomycin biosynthetic gene cluster ofStreptomyces pyridomyceticus NRRL B-2517. J Biol Chem, 2011, 286(23):20648-57.

    6.Galm U, Wendt-Pienkowski E, Wang L, Huang SX, Unsin C, Tao M, Coughlin JM, Shen B*. Comparative analysis of the biosynthetic gene clusters and pathways for three structurally related antitumor antibiotics: bleomycin, tallysomycin, and zorbamycin. J Nat Prod, 2011, 74(3):526-36.

    7.Zhang N, Zhu X, Yang D, Cai J, Tao M, Wang L, Duan Y, Shen B*, Xu Z*. Improved production of the tallysomycin H-1 in Streptoalloteichus hindustanusSB8005 strain by fermentation optimization. Appl Microbiol Biotechnol. 2010, 86(5):1345-53.

    8.Tao M†, Wang L†, Wendt-Pienkowski E, Zhang N, Yang D, Galm U, Coughlin JM, Xu Z, Shen B*. Functional characterization of tlmH in Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insight into tallysomycin biosynthesis and affording a novel bleomycin analog. Mol Biosyst2010, 6(2):349-56.

    9.Chen W, Qu D, Zhai L, Tao M, Wang Y, Lin S, Price NP*, Deng Z*. Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis. Protein Cell. 2010, 1(12):1093-105.

    10.Wang L†, Tao M†, Wendt-Pienkoski E, Galm U, Coughlin JM, Shen B*.Functional characterization of tlmK unveiling unstable carbinolamide intermediates in the tallysomycin biosynthetic pathway. J Biol Chem, 2009, 284(13):8256-64.

    11.Galm U, Wendt-Pienkowski E, Wang L, George NP, Oh TJ, Yi F, Tao M, Coughlin JM, Shen B*. The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridisATCC 21892. Mol Biosyst. 2009,5(1):77-90.

    12.Galm U, Wang L, Wendt-Pienkowski E, Yang R, Liu W, Tao M, Coughlin JM, Shen B*. In vivo manipulation of the bleomycin biosynthetic gene cluster inStreptomyces verticillus ATCC15003 revealing new insights into its biosynthetic pathway. J Biol Chem, 2008, 283(42):28236-45.

    13.Xu H, Chater KF, Deng Z, Tao M*. A cellulose synthase-like protein involved in hyphal tip growth and morphological differentiation in StreptomycesJ Bacteriol, 2008, 190(14):4971-8.

    14.Li W, Zou H, Tao M*Sequences downstream of the start codon and their relations to G + C content and optimal growth temperature in prokaryotic genomes. Antonie Van Leeuwenhoek,  2007, 92(4):417-27.

    15.Wang L, Yun BS, George NP, Wendt-Pienkowski E, Galm U, Oh TJ, Coughlin JM, Zhang G, Tao M, Shen B*. Glycopeptide antitumor antibiotic zorbamycin from Streptomyces flavoviridis ATCC 21892: strain improvement and structure elucidation. J Nat Prod, 2007, 70(3):402-6. 

    16.Wang L, Yu Y, He X, Zhou X, Deng Z, Chater KF, Tao M*. Role of an FtsK-like protein in genetic stability in Streptomyces coelicolor A3(2).  J Bacteriol2007, 189(6):2310-8.

    17.Tao M, Wang L, Wendt-Pienkowski E, George NP, Galm U, Zhang G, Coughlin JM, Shen B*. The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics.  Mol Biosyst, 2007, 3(1):60-74.

    18.Li W, Wu J, Tao W, Zhao C, Wang Y, He X, Chandra G, Zhou X, Deng Z, Chater KF, Tao M*A genetic and bioinformatic analysis of Streptomyces coelicolorgenes containing TTA codons, possible targets for regulation by a developmentally significant tRNA. FEMS Microbiol Lett, 2007, 266(1):20-8. 

    19.Li W, Ying X, Guo Y, Yu Z, Zhou X, Deng Z, Kieser H, Chater KF, Tao M*.Identification of a gene negatively affecting antibiotic production and morphological differentiation in Streptomyces coelicolor A3(2).J Bacteriol, 2006, 188(24):8368-75.

    20.Takano E†, Tao M†, Long F, Bibb MJ, Wang L, Li W, Buttner MJ, Bibb MJ, Deng ZX, Chater KF*. A rare leucine codon in adpA is implicated in the morphological defect of bldA mutants of Streptomyces coelicolorMol Microbiol, 2003, 50(2):475-86.

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