夏小霞

姓名: 夏小霞

职称: 研究员

E-Mail: xiaoxiaxia@sjtu.edu.cn

个人主页: http://mbe.sjtu.edu.cn/index.asp

联系电话: 021-34207254

  • 个人简历:

    个人简介

    上海交通大学特别研究员、上海市高校特聘教授(东方学者)、博士生导师,2013年入选上海市浦江人才计划。主要从事系统与合成生物学研究,特别是在生物材料、绿色化工和能源等领域的应用基础研究,在国际重要学术刊物Proc Natl Acad Sci USA、J Am Chem Soc、Adv Func Mater等发表研究论文近三十篇,其中部分论文被遴选为Nature 的Research Highlights、Nat Chem Biol 的News and Views及Biotechnol Bioeng的封面等。四项韩国发明专利和一项澳大利亚专利已获得授权。被邀请为 Biotechnology & Bioengineering,Biomacromolecules等多个国际杂志的论文审稿人。

    教育经历

    2005.3-2009.1   韩国科学技术院  生命化学工学科  博士

    2001.9-2004.3   华东理工大学    发酵工程        硕士

    1997.9-2001.7   南昌大学        发酵工程        本科

    工作经历

    2012.9-至今     上海交通大学生命科学技术学院     研究员

    2010.7-2012.8    美国Tufts大学NIH组织工程中心  博士后

    2009.2-2010.6    韩国科学技术院生物过程工程中心  博士后

    荣誉奖励

    上海市浦江人才计划 2013

    上海市高校特聘教授(东方学者)2012

    Poster Award   Korea Microbiology and Biotechnology (KMB) international symposium & annual meeting  2012

    Poster Award   Korea Microbiology and Biotechnology (KMB) international symposium & annual meeting     Gyeongju   Korea   June 24    2011

    上海市研究生学位论文优秀成果    2006

  • 1. 合成生物学

    2.  系统代谢工程

    3.  生物材料

  • 1.     Yu JL, Xia XX, Zhong JJ*, Qian ZG*. Direct biosynthesis of adipic acid from a synthetic pathway in recombinant Escherichia coli. Biotechnol Bioeng, 2014, DOI: 10.1002/bit.25293

    2.     Xu YN, Xia XX, Zhong JJ*. Induction of ganoderic acid biosynthesis by Mn2+ in static liquid cultivation of Ganoderma lucidum. Biotechnol Bioeng, 2014, DOI: 10.1002/bit.25288

    3.     Qi K, Zhong JJ*, Xia XX*. Interruption of cat8, a putative transcriptional regulator in glucose signaling cascade, triggered aerobic ethanol production in Crabtree negative yeast Pichia guilliermondii. Appl Environ Microbiol, 2014, 80(13):3879-3887 (co-corresponding authors)

    4.     Wang Q†, Xia X†, Huang W, Lin Y, Xu Q, Kaplan DL. High throughput screening of dynamic silk-elastin-like protein biomaterials. Adv Funct Mater, 2014, 24(27):4303-4310 (Co-first authors)

    5.     Lin Y†, Xia XX†, Wang M†, Wang Q, An B, Tao H, Xu Q, Kaplan DL. Genetically programmable thermoresponsive plasmonic gold/silk-elastin protein core/shell nanoparticles. Langmuir, 2014, 30(15):4406-4414 (Co-first authors)

    6.     Xia XX†, Wang M†, Lin Y, Xu Q, Kaplan DL. Hydrophobic drug-triggered self-assembly of nanoparticles from silk-elastin-like protein polymers for drug delivery. Biomacromolecules, 2014, 15(3):908-914. (Co-first authors)

    7.     Lin Y, Xia X, Shang K, Elia R, Huang W, Cebe P, Leisk G, Omenetto F, Kaplan DL. Tuning chemical and physical cross-links in silk hydrogels for morphological analysis and mechanical reinforcement. Biomacromolecules, 2013, 14(8):2629–2635.

    8.     Fan C, Qi K, Xia XX*, Zhong JJ*. Efficient ethanol production from corncob residues by repeated fermentation of an adapted yeast. Bioresources Technol, 2013, 136:309-315.

    9.     Hu X, Tang-Schomer MD, Huang W, Xia XX, Weiss AS, Kaplan DL. Charge-tunable autoclaved silk-tropoelastin protein alloys that control neuron cell responses. Adv Funct Mater, 2013, 23(31):3875-3884.

    10.   Sun Z, Qin G, Xia X, Mark, CG, Omenetto, F, Kaplan DL. Photoresponsive retinal-modified silk-elastin copolymer. J Am Chem Soc, 2013, 135 (9): 3675–3679.

    11.   Xu YN, Xia XX, Zhong JJ. Induced effect of Na+ on ganoderic acid biosynthesis in static liquid culture of Ganoderma lucidum via calcineurin signal transduction. Biotechnol Bioeng, 2013, 110(7):1913-1923. (Spotlight paper)

    12.   An B, DesRochers TM, Qin G, Xia X, Thiagarajan G, Brodsky B, Kaplan DL. The influence of specific binding of collagen-silk chimeras to silk biomaterials on hMSC behavior. Biomaterials, 2013, 34(2):402-412.

    13.   Xia XX, Xu Q, Hu X, Qin G, Kaplan DL. Tunable self-assembly of genetically engineered silk-elastin protein polymers. Biomacromolecules, 2011, 12(11):3844-3850.

    14.   Hu X, Park SH, Gil ES, Xia XX, Weiss AS, Kaplan DL. The influence of elasticity and surface roughness on myogenic and osteogenic-differentiation of cells on silk-elastin biomaterials. Biomaterials, 2011, 32(34):8979-8989.

    15.   Xia XX, Qian ZG, Lee SY. Comparative proteomic and genetic analyses reveal unidentified mutations in Escherichia coli XL1-Blue and DH5α. FEMS Microbiol Lett, 2011, 314(2):119-124.

    16.   Qian ZG, Xia XX, Lee SY. Metabolic engineering of Escherichia coli for the production of cadaverine: A five carbon diamine. Biotechnol Bioeng, 2011, 108(1): 93-103.

    17.   Xia XX, Qian ZG, Ki CS, Park YH, Kaplan DL, Lee SY. Native-sized recombinant spider silk protein produced in metabolically engineered Escherichia coli results in a strong fiber. Proc Natl Acad Sci USA, 2010, 107(32):14059-14063.

    18.   Qian ZG, Xia XX, Lee SY. Metabolic engineering of Escherichia coli for the production of putrescine: A four carbon diamine. Biotechnol Bioeng, 2009, 104(4):651-662.

    19.   Xia XX, Han MJ, Lee SY, Yoo JS. Comparison of the extracellular proteomes of Escherichia coli B and K-12 strains during high cell density cultivation.Proteomics, 2008, 8(1): 2089-2103.

    20.   Qian ZG†, Xia XX†, Lee SY. Proteome-based identification of fusion partner for high-level extracellular production of recombinant proteins in Escherichia coli.Biotechnol Bioeng, 2008, 101(3):587-601. (†equal contribution)

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