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学术报告

【启智讲坛第二十五讲】NEW Drugs from OLD Pathways - Teaching Nature New Tricks

主要完成人: 发表日期:2017-10-23 点击数:159

报告人/Speaker: Professor Thomas J. Simpson

                            Alfred Capper Pass Chair of Chemistry

University of Bristol, UK

Elected Fellow of the Royal Society

Elected Fellow of the Royal Society of Edinburgh

报告时间/Date: 20171030日(星期一),13:30-15:00

报告地点/Location: 闵行校区生命学院树华多功能厅(800号)
报告摘要/Abstract:

Engineering metabolic pathways in microorganisms can provide new antibiotics and other bioactive natural products.The mupirocins, e.g. pseudomonic acid A and thiomarinols isolated from Pseudomonas and Pseudoalteromonas bacteria are antibiotics active against MRSA. Clinical applications are restricted by instability in the former and toxicity in the latter. Using classical biosynthetic methods to understand how they are formed, combined with molecular genetic engineering, novel analogues in which both these limitations can be produced. Similarly, the biosynthetic pathway to the fungal metabolite, tenellin, isolated from Beauvaria bassiana, has been engineered to produce the “extinct” compound, bassianin, and many new compounds for biological evaluation.