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学术报告

【启智讲坛第十三讲】面向化学品和材料的微生物代谢工程

主要完成人: 发表日期:2014-09-18 点击数:676

 

报 告  人:李相烨 博士(Sang Yup Lee)

韩国科学技术院(KAIST)特聘教授

韩国国家科学与工程院院士

美国工程院外籍院士

报告时间:9月18号(星期四) 10:00

报告地点:闵行校区生物药学楼树华多功能厅

联 系  人:钱志刚 zgqian@sjtu.edu.cn 13817451799

报告摘要:Microbial metabolic engineering for chemicals and materials

Sang Yup Lee

Department of Chemical and Biomolecular Engineering, KAIST, Daejeon, Republic of Korea

Due to our increasing awareness of climate change and environmental problems in addition to the limited nature of fossil resources, there has recently been much interest in developing sustainable system for the production of chemicals, fuels, and materials from renewable resources. Metabolic engineering has been successfully practices over two decades for the enhanced production of chemicals and pharmaceuticals. More recent advances in systems biology, synthetic biology and evolutionary engineering are allowing metabolic engineering to be performed at systems level. In this lecture, systems metabolic engineering strategies that integrate systems biological and synthetic biological approaches with metabolic engineering will be described. Several examples of producing chemicals, fuels and materials will be described in the context of systems metabolic engineering. First, amino acids will be used as example products of systems metabolic engineering. How cellular networks are engineered to overcome negative regulatory circuits, reinforcing the metabolic fluxes towards the desired product, and how fermentation is coupled during the strain development will be described. Also, development of microbial strains for the production of other chemicals and materials of industrial importance will be showcased. [Our work has been supported by the Technology Development Program to Solve Climate Changes from the Ministry of Education, Science and Technology.]

Recent references

1. Lee, J.W. et al., Nature Chemical Biology 2012, 8, 536 – 546

2. Na, D. et al., Nature Biotechnology, 2013, 31, 170 - 174

3. Choi, Y.J. and Lee, S.Y., Nature, 2013, 502, 571 – 574

4. Kim, B. et al., Biotechnol. J., 2014, 9, 621-629

5. Choi, S. et al., Metabol. Eng., 2013, 20, 73-83

more references from http://mbel.kaist.ac.kr/lab/publication/interJournal/interJournal.htm