Shuangjun Lin

Shuangjun Lin

Researcher

E-mail:linsj@sjtu.edu.cn

Website:http://mml.sjtu.edu.cn

Phone:34206722

Resume
Dr. Shuangjun Lin received his Ph.D degree in organic chemistry at the Institute of Chemistry, Chinese Academy of Sciences in 2002. He had postdoctoral research experience at University of Alberta in Canada and University of Wisconsin-Madison from 2002 to 2008, respectively. He was appointed a professor in Shanghai Jiao Tong University since the end of 2008. His current research is focused on the discovery of bioactive natural products from microbes and natural product biosynthesis.

Education Experience 
2002.09-2002.08  Ph.D.   Institute of Chemistry    Chinese Academy of Sciences
1996.09-1999.07  M.Sc.   organic chemistry  Shanghai Institute of Materia Medica     Chinese Academy of Sciences
1992.09-1996.07  B. Sc.    chemistry   Ji Lin University

Work Experience 
2008.11-      Professor School of Life Sciences and Biotechnology    Shanghai Jiao University
2005.09-2008.09 Research Associate School of Pharmacy     University of Wisconsin-Madison     USA
2002.12-2005.08  Postdoctoral Fellow Department of Chemistry   University of Alberta    Canada

 

1. Biosynthesis of natural products and synthetic biology

2. Discovery and structural elucidation of biologically active natural products from special microorganisms

3. Enzymatic mechanism and application of enzymes in organic synthesis

1.       Kong D, Lee MJ, Lin S*, Kim ES*. Biosynthesis and pathway engineering of antifungal polyene macrolides in actinomycetes. J Ind Microbiol Biotechnol, 2013, 40(6):529-43.

2.       Lin S, Huang T, Shen B*. Tailoring enzymes acting on carrier protein-tethered substrates in natural product biosynthesis. Methods Enzymol, 2012, 516:321-43.

3.       Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B*. Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis. Org Lett, 2012, 14(9):2300-3.

4.       Lin S, Horsman GP, Shen B*. Characterization of the epoxide hydrolase NcsF2 from the neocarzinostatin biosynthetic gene cluster. Org Lett, 2010, 12(17):3816-3819.

5.       Lin S, Van Lanen SG and Shen B*. A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis. Proc. Natl. Acad. Sci. U.S.A, 2009, 106(11):4183-4188.

6.       Lin S, Horsman GP, Chen Y, Li W, Shen B*. Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis. J Am Chem Soc, 2009, 131(45):16410-16417.

7.       Lin S, Van Lanen SG, Shen B*.Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027. J Am Chem Soc, 2008, 130(20):6616-6623.

8.       Van Lanen SG, Lin S, Shen B*. Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism. Proc. Natl. Acad. Sci. U.S.A, 2008, 105(2):494-499.

Lin S, Van Lanen SG, Shen B*. Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027. J Am Chem Soc, 2007, 129(41):12432-12438.


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