微生物代谢国家重点实验室-科研队伍

欧竑宇

姓名: 欧竑宇

职称: 教授

E-Mail: hyou@sjtu.edu.cn

个人主页: http://bioinfo-mml.sjtu.edu.cn/

联系电话: 62932943*2132

个人简历:

个人简介

教授，博士生导师。长期从事微生物基因组学和生物信息学交叉研究，关注耐药条件致病菌和抗生素产生菌链霉菌的比较组学分析，围绕细菌可移动基因组的功能解析开发了一系列生物信息学工具和分子生物学数据库。已在Nucleic Acids Research (7篇)、Journal of Bacteriology、Journal of Molecular Diagnostics、FEBS Letters、Int. J. Biochem. Cell Biol.、PloS Genetics、Molecular Microbiology、PloS ONE等刊物发表三十余篇论文。主持多项863计划和国家自然科学基金项目。入选教育部新世纪优秀人才资助计划和上海市青年科技启明星计划，曾获明治乳业生命科学奖。多次在国内外学术会议上作报告和担任会场主持人，多次担任BMC Genomics、Gene、Biochimie、Journal of Theoretical Biology等十余个国内外生物学刊物的审稿人。

教育经历

2001.03-2004.02 天津大学        博士

1998.09-2001.03 天津科技大学    硕士

1993.09-1997.07 南京农业大学    本科

工作经历

2012.01-         上海交通大学生命科学技术学院教授

2006.06-2011.12 上海交通大学   生命科学技术学院副教授

2004.06-2006.05 英国莱斯特大学医学院           博士后研究助理

荣誉奖励

2012 上海交通大学晨星青年学者奖励计划SMC优秀青年教师（A类）

2009 上海交通大学晨星青年学者奖励计划SMC优秀青年教师（A类）

2010   教育部新世纪优秀人才计划

2008   明治乳业生命科学奖

2007   上海市青年科技启明星（A类）

2006   全国优秀博士学位论文提名论文
1.耐药条件致病菌组学数据的挖掘

2.细菌可移动基因组的生物信息学研究

3.链霉菌抗生素生物合成基因簇的分析
1. Bi D, Liu L, Tai C, Deng Z, Rajakumar K*, Ou HY*. SecReT4: a web-based bacterial type IV secretion system resource. Nucleic Acids Res, 2013, 41: D660-D665.

2. Ou HY*, Wei Y, Bi D. Book chapter: “Type II Loci: Phylogeny”. Prokaryotic Toxin-Antitoxins, Editor Kenn Gerdes, 2013, Springer.

3. Bi D, Xu Z, Harrison E, Tai C, Wei Y, He X, Jia S, Deng Z, Rajakumar K*, Ou HY*. ICEberg: a web-based resource for integrative and conjugative elements found in Bacteria. Nucleic Acids Res, 2012, 40:D621-D626.

4. Liu P, Li P, Jiang X, Bi D, Xie Y, Tai C, Deng Z, Rajakumar K, Ou H.Y.*. Complete Genome Sequence of Klebsiella pneumoniae subsp. pneumoniaeHS11286, a Multidrug-Resistant Strain Isolated from Human Sputum. J Bacteriol, 2012, 194(7):1841-2.

5. Li J, Qu X, He X, Duan L, Wu G, Bi D, Deng Z, Liu W*, Ou HY*. ThioFinder: a web-based tool for the identification of thiopeptide gene clusters in DNA sequences. PloS ONE, 2012, 7(9):e45878.

6. Zhao C, Li P, Deng Z, Ou HY*, McGlinchey RP, O'Hagan D*. Insights into fluorometabolite biosynthesis in Streptomyces cattleya DSM46488 through knockout mutants. Bioorg Chem, 2012, 44:1-7.

7. Shao Y, Harrison EM, Bi D, Tai C, He X, Ou HY*, Rajakumar K, Deng Z. TADB: a web-based resource for Type 2 toxin-antitoxin loci in bacteria and archaea.Nucleic Acids Res, 2011, 39:D606-D611.

8. Zhang J, van Aartsen JJ, Jiang X, Shao Y, Tai C, He X, Tan Z, Deng Z, Jia S, Rajakumar K, Ou HY*. Expansion of the known Klebsiella pneumoniaespecies gene pool by characterization of novel alien DNA islands integrated into tmRNA gene sites. J Microbiol Methods, 2011, 84(2):283-9.

9. Book chapter: “ArrayOme- & tRNAcc-facilitated mobilome discovery: comparative genomics approaches for identifying rich veins of bacterial novel DNA sequences”. Ou HY, Rajakumar K, Handbook of Molecular Microbial Ecology I: Metagenomics and Complementary Approaches, Editor F. J. de Bruijn, 2011, John Wiley & Sons, Inc.

10. Liu G, Ou HY, Wang T, Li L, Tan H, Zhou X, Rajakumar K, Deng Z*, He X*. Cleavage of phosphorothioated DNA and methylated DNA by the type IV restriction endonuclease ScoMcrA. PLoS Genet, 2010, 6(12):e1001253.

11. Shao Y, He X, Tai C, Ou HY*, Rajakumar K, Deng Z. mGenomeSubtractor: a web-based tool for parallel in silico subtractive hybridization analysis of multiple bacterial genomes. Nucleic Acids Res, 2010, 38:W194-W200.

12. Chen N†, Ou HY†, van Aartsen JJ, Jiang X, Li M, Yang Z, Wei Q, Chen X, He X, Deng Z, Rajakumar K, Lu Y*. The pheV phenylalanine tRNA gene in Klebsiella pneumoniae clinical isolates is an integration hotspot for possible niche-adaptation genomic islands. Curr Microbiol, 2010, 60(3):210-6.

13. Ou HY, He X, Shao Y, Tai C, Rajakumar K, Deng Z*. dndDB: a database focused on phosphorothioation of the DNA backbone. PLoS ONE, 2009, 4(4):e5132.

14. Ou HY†, Ju† CTS, Thong KL, Ahmad N, Deng Z, Barer MR, Rajakumar K*.Translational genomics to develop a Salmonella enterica serovar Paratyphi A multiplex polymerase chain reaction assay. J Mol Diagn, 2007, 9(5):624-30.

15.Ou HY, He X, Harrison EM, Kulasekara BR, Thani AB, Kadioglu A, Lory S, Hinton JC, Barer MR, Deng Z*, Rajakumar K*, MobilomeFINDER: web-based tools for in silico and experimental discovery of bacterial genomic islands. Nucleic Acids Res, 2007, 35, W97-W104.

16.He X, Ou HY, Yu Q, Zhou X, Wu J, Liang J, Zhang W, Rajakumar K, Deng Z*.Analysis of a genomic island housing genes for DNA S-modification system in Streptomyces lividans 66 and its counterparts in other distantly related bacteria. Mol Microbiol, 2007, 65(4):1034-48.

17.Ou HY, Chen LL, Lonnen J, Chaudhuri RR, Thani AB, Smith R, Garton NJ, Hinton JC, Pallen M, Barer M, Rajakumar K*. A novel strategy for identification of genomic islands by comparative analysis of the contents and contexts of tRNA sites in closely related bacteria. Nucleic Acids Res, 2006, 34(1):e3.

18. Ou HY, Smith R, Lucchini S, Hinton JC, Chaudhuri RR, Pallen M, Barer M, Rajakumar K*. ArrayOme: a program for estimating the sizes of the microarray-visualised genomes. Nucleic Acids Res, 2005, 33(1):e3.