微生物代谢国家重点实验室-科研队伍

夏小霞

姓名: 夏小霞

职称: 研究员

E-Mail: xiaoxiaxia@sjtu.edu.cn

个人主页: http://mbe.sjtu.edu.cn/index.asp

联系电话: 021-34207254

个人简历:

（1）个人简介

上海交通大学特别研究员、博士生导师。主要从事合成与系统生物技术研究，尤其致力于蛋白材料等生物工程领域的基础及应用基础研究。在PNAS、Advanced Functional Materials、Biomacromolecules等国际期刊发表SCI研究论文40篇，代表性人工蜘蛛丝研究成果被Nature Chemical Biology和麻省理工学院出版的Technology Review以“新闻和观点”和专题等形式作了评论和推介，获得美国、澳大利亚等国家发明专利授权10余项，应邀在包括2017年国际合成生物学大会、2015年哥本哈根生物科学会议等有影响的国际会议作学术报告10余次，2016年起应邀担任《微生物学杂志》及国际期刊Biotechnology Journal编委。

（2）荣誉奖励

上海市浦江人才计划2013
（1）蜘蛛丝等蛋白材料的仿生生物合成

（2）智能生物材料的创新设计与合成
1. Huang SC†, Qian ZG†, Dan AH, Hu X, Zhou ML, Xia XX*. Rational design and hierarchical assembly of a genetically engineered resilin-slik copolymer results in stiff hydrogels. ACS Biomater Sci Eng, 2017, 3(8):1576–1585.

2. Chen L, Zhou ML, Qian ZG, Kaplan DL, Xia XX*. Fabrication of protein films from genetically engineered silk-elastin-like proteins by controlled cross-linking. ACS Biomater Sci Eng, 2017, 3(3):335-341.

3. Zhou ML, Qian ZG, Chen L, Kaplan DL, Xia XX*. Rationally designed redox-sensitive protein hydrogels with tunable mechanical properties. Biomacromolecules, 2016, 17(11): 3508-3515.

4. Peng Q, Zhang Y*, Lu L, Shao H, Qin K, Hu X, Xia X*. Recombinant spider silk from aqueous solutions via a bio-inspired microfluidic chip. Sci Rep, 2016, 6, 36473.

5. Qin N, Zhang S, Jiang J, Corder SG, Qian Z, Zhou Z, Lee W, Liu K, Wang X, Li X, Shi Z, Mao Y, Bechtel HA, Martin MC, Xia X, Marelli B, Kaplan DL, Omenetto FG, Liu M, Tao TH. Nanoscale probing of electron-regulated structural transitions in silk proteins by near-field IR imaging and nano-spectroscopy. Nat Commun, 2016, 7:13079.

6. Yang YX, Qian ZG, Zhong JJ*, Xia XX*. Hyper-production of large proteins of spider dragline silk MaSp2 by Escherichia coli via synthetic biology approach. Process Biochem, 2016, 51(4): 484-490.

7. Qian ZG†, Zhou ML†, Song WW, Xia XX*. Dual thermosensitive hydrogels assembled from the conserved C-terminal domain of spider dragline silk. Biomacromolecules, 2015, 16(11):3704–3711.

8. Qi K, Zhong JJ*, Xia XX*. Triggering respirofermentative metabolism in the Crabtree-negative yeast Pichia guilliermondii by disrupting the CAT8 Gene. Appl Environ Microbiol, 2014, 80(13):3879-3887.

9. Wang Q†, Xia X†, Huang W, Lin Y, Xu Q, Kaplan DL*. High throughput screening of dynamic silk-elastin-like protein biomaterials. Adv Funct Mater, 2014, 24(27):4303-4310.

10. Xia XX†, Wang M†, Lin Y, Xu Q, Kaplan DL*. Hydrophobic drug-triggered self-assembly of nanoparticles from silk-elastin-like protein polymers for drug delivery. Biomacromolecules, 2014, 15(3):908-914.