微生物代谢国家重点实验室-科研队伍

赵立平

姓名: 赵立平

职称: 教授

E-Mail: lpzhao@sjtu.edu.cn

个人主页: http://moleco.sjtu.edu.cn/home.htm

联系电话: 021-34204877

个人简历:

个人简介

所领导的团队在国内最早系统开展微生物分子生态学研究，在复杂微生物群落结构分析技术和统计计算方法、结构与功能相关性等方面做了很多创新性工作，特别在肠道菌群与肥胖等代谢性疾病的关系方面取得重要进展，提出“代谢性疾病的肠源性学说”。在美国科学院院报（PNAS）, 国际微生物生态学会会刊（ISME Journal）等刊物发表研究论文四十余篇。应邀在国际微生物生态学大会、国际人类微生物组大会、国际糖尿病技术大会、美国微生物学会年会等一系列国际会议做大会报告、特邀报告。目前的研究重点是，营养如何通过改变菌群从而影响代谢性疾病的发生和发展，以及如何挖掘、利用中国传统养生食材和中医药中的有效成分，通过调理菌群结构进行代谢性疾病的预防和治疗。

教育经历

1993.9-1995.9 美国康奈尔大学植物系      访问学者

1983.9-1989.3 南京农业大学植物病理学系博士

工作经历

2013-今     上海交通大学生命科学与技术学院教授

2005-今     上海系统生物医学研究中心        副主任

2003-2013   上海交通大学生命科学与技术学院教授、副院长

2001-2003   上海交通大学生物技术系          教授、系主任

2000.4-2000.7 美国加州大学Riverside分校植物病理学系南卡大学环境工程系   访问教授

1997-2001    山西大学生物工程研究所         教授、所长

1995.9-1997   山西大学生物工程研究所         副教授

1989.3-1993.9 山西农科院生物工程研究室      副主任

荣誉奖励

2009年上海市优秀学科带头人
1.微生物分子生态学：微生物群落的结构解析新技术，微生物群落元基因组学

2.人体系统生物学：肠道菌群结构和功能变化与代谢性疾病发生发展的关系

3.多元统计与生物信息在微生物生态学领域的应用研究
1.   Fei N, Zhao LP*. An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice. ISME J, 2013, 7(4):880-4.

2.   Shen J, Obin MS, Zhao LP*. The gut microbiota, obesity and insulin resistance. Mol Aspects Med, 2013, 34(1):39-58.

3.       Zhang X, Zhao Y, Zhang M, Pang X, Xu J, Kang C, Li M, Zhang Y, Zhang Z, Li X, Ning G, Zhao LP*. Structural Changes of Gut Microbiota during Berberine-mediated Prevention of Obesity and Insulin Resistance in High-Fat Diet-Fed Rats. Plos One, 2012, 7(8):e42529.

4.         Zhao LP*, Nicholson JK*, Lu A, Wang Z, Tang H, Holmes E, Shen J, Zhang X, Li JV, Lindon JC.. Targeting the Human Genome−Microbiome Axis for Drug Discovery: Inspirations from Global Systems Biology and Traditional Chinese Medicine. J Proteome Res, 2012, 11(7): 3509–3519.

5.         Zhang C, Zhang M, Pang X, Zhao Y, Wang L and Zhao LP*. Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations.ISME J, 2012, 6(10):1848-57.

6.         Wang T, Cai G, Qiu Y, Fei N, Zhang M, Pang X, Jia W, Cai S, Zhao LP*.Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers. ISME J, 2012, 6(2):320-9.

7.         van Hylckama Vlieg JE, Veiga P, Zhang C, Derrien M, Zhao LP*. Impact of microbial transformation of food on health-from fermented foods to fermentation in the gastro-intestinal tract.. Curr Opin Biotech, 2011, 22(2):211-219.

8.         Wei H, Dong L, Wang T, Zhang M, Hua W, Zhang C, Pang X, Chen M, Su M, Qiu Y, Zhou M, Yang S, Chen Z, Rantalainen M, Nicholson J.K., Jia W, Wu D,Zhao LP*. Structural shifts of gut microbiota as surrogate endpoints for monitoring host health changes induced by carcinogen exposure. FEMS Microbiol Ecol, 2010, 73(3):577-586.

9.         Zhao LP*, Shen J. Whole-body systems approaches for gut microbiota-targeted, preventive healthcare. J Biotechnol, 2010, 149(3):183-90.

10.     Zhang C, Zhang M, Wang S, Han R, Cao Y, Hua W, Mao Y, Zhang X, Pang X, Wei C, Zhao G, Chen Y, Zhao LP*.. Interactions between gut microbiota, host genetics, and diet relevant to development of metabolic syndromes in mice.ISME J, 2010, 4(2): 232-241.

11.     Zhang M, Zhang M, Zhang C, Du H, Wei G, Pang X, Zhou H, Liu B, Zhao LP*.Pattern extraction of structural responses of gut microbiota to rotavirus infection via multivariate statistical analysis of clone library data. FEMS Microbiol Ecol,2009, 70(2):21-9.

12.     Li M, Wang B, Zhang M, Rantalainen M, Wang S, Zhou H, Zhang Y, Shen J, Pang X, Zhang M, Wei H, Chen Y, Lu H, Zuo J, Su M, Qiu Y, Jia W, Xiao C, Smith LM,Yang S, Holmes E, Tang H, Zhao G, Nicholson JK, Li L, Zhao LP*. Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A,2008, 105(6):2117-22.

13.     Jia W，Li H, Zhao LP & Nicholson JK. Gut microbiota: a potential new territory for drug targeting. Nat Rev Drug Discov, 2008, 7(2):123-9.

14.     Pang X, Hua X, Yang Q, Ding D, Che C, Cui L, Jia W, Bucheli P, Zhao LP*..Inter-species transplantation of gut microbiota from human to pigs. ISME J, 2007, 1(2):156-62.

15.     Zhang M, Liu B, Zhang Y, Wei H, Lei Y, Zhao LP*. Structural shifts of mucosa-associated Lactobacilli and Clostridium leptum subgroup in patients with ulcerative colitis. J Clin Microbiol, 2007, 45(2):496-500.

16.     Yan X, Xu Z, Feng X, Liu Y, Liu B, Zhang X, Zhu C, Zhao LP*. Cloning of environmental genomic fragments as physical markers for monitoring microbial populations in coking wastewater treatment system. Microb Ecol, 2007, 53(1):163-72.

17.     Wei G, Lu H, Zhou Z, Xie H, Wang A, Nelson K, Zhao LP*. The microbial community in the feces of the giant panda (Ailuropoda melanoleuca) as determined by PCR-TGGE profiling and clone library analysis. Microb Ecol,2007, 54(1):194-202.

18.     Liu B, Zhang F, Feng X, Liu Y, Yan X, Zhang X, Wang L, Zhao LP*.Thauera and Azoarcus as Functionally Important Genera in a Denitrifying Quinoline Removal Bioreactor as Revealed by Microbial Community Structure Comparison. FEMS Microbiol. Ecol.，2006, 55(2):274-86.

19.     Shen J, Zhang B, Wei G, Pang X, Wei H, Li M, Zhang Y, Jia W, Zhao LP*. ?Molecular Profiling of the Clostridium leptum Subgroup in Human Fecal Microflora by PCR-Denaturing Gradient Gel Electrophoresis and Clone Library Analysis.Appl Environ Microbiol, 2006, 72(8):5232-5238.

20.     Pang X, Ding D, Wei G, Zhang M, Wang L, Zhao LP*. Molecular profiling of Bacteroides spp. in human feces by PCR-temperature gradient gel electrophoresis. J Microbiol Methods, 2005, 61(3):413-7.