主要完成人: 发表日期:2016-09-26






Formation of the delta(18,19) double bond and bis(spiroacetal) in salinomycin is atypically catalyzed by SlnM, a methyltransferase-like enzyme.

Jiang C, Qi Z, Kang Q, Liu J, Jiang M, Bai L

Angew Chem Int Edit, 2015, 54(31):9097-100


Recognition and cleavage of 5-methylcytosine DNA by bacterial SRA-HNH proteins

Han T, Yamada-Mabuchi M, Zhao G, Li L, Liu G, Ou HY, Deng Z, Zheng Y, He X

Nucleic Acids Res, 2015, 43(2):1147-59.


Mechanisms of acid tolerance in bacteria and prospects in biotechnology and bioremediation

Liu Y, Tang H, Lin Z, Xu P

Biotechnol Adv,

2015, 33(7):1484-92.


Production of C3 platform chemicals from CO2 by genetically engineered cyanobacteria

Wang Y, Tao F, Ni J, Li C, Xu P

Green Chem,

2015, 17(5): 3100–3110


An artificial enzymatic reaction cascade for a cell-free bio-system based on glycerol

Gao C, Li Z, Zhang LJ, Wang C, Li K, Ma CQ, Xu P

Green Chem,

2015, 17(2): 804–807


The bamboo-eating giant panda harbors a carnivore-like gut microbiota, with excessive seasonal variations

Xue Z, Zhang W, Wang L, Hou R, Zhang M, Fei L, Zhang X, Huang H, Bridgewater LC, Jiang Y, Jiang C, Zhao L, Pang X, Zhang Z


2015, 6(3):e00022-15.


Engineering the central biosynthetic and secondary metabolic pathways of Pseudomonas aeruginosa strain PA1201 to improve phenazine-1-carboxylic acid production

Jin K, Zhou L, Jiang H, Sun S, Fang Y, Liu J, Zhang X, He YW

Metab Eng,

2015, 32:30-8.


Engineering validamycin production by tandem deletion of gamma-butyrolactone receptor genes in Streptomyces hygroscopicus 5008

Tan GY, Peng Y, Lu C, Bai L, Zhong JJ

Metab Eng,

2015, 28:74-81.


Cytotoxic T cell responses are enhanced by antigen design involving the presentation of MUC1 peptide on cholera toxin B subunit

Lu W, Qiu L, Yan Z, Lin Z, Cao M, Hu C, Wang Z, Wang J, Yu Y, Cheng X, Cao P, Li R


2015, 6(33):34537-48.


Identification and characterization of naturally occurring DSF-family quorum sensing signal turnover system in the phytopathogen Xanthomonas

Zhou L, Wang XY, Sun S, Yang LC, Jiang BL, He YW

Environ Microbiol,

2015, 17(11):4646-58.


SecReT6: a web-based resource for type VI secretion systems found in bacteria

Li J, Yao Y, Xu HH, Hao L, Deng Z, Rajakumar K, Ou HY

Environ Microbiol,

2015, 17(7):2196-202.


Dual thermosensitive hydrogels assembled from the conserved C-terminal domain of spider dragline silk

Qian ZG, Zhou ML, Song WW, Xia XX


2015, 16(11):3704-11.


Chemical analysis of the Chinese liquor Luzhoulaojiao by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry

Yao F, Yi B, Shen C, Tao F, Liu Y, Lin Z, Xu P

Sci Rep,

2015, 5:9553.


Comparative genome analysis reveals the molecular basis of nicotine degradation and survival capacities of Arthrobacter

Yao Y, Tang H, Su F, Xu P

Sci Rep,

2015, 5:8642.


Complete genome sequence of hypervirulent and outbreak-associated Acinetobacter baumannii strain LAC-4: epidemiology, resistance genetic determinants and potential virulence factors

Ou HY, Kuang SN, He X, Molgora BM, Ewing PJ, Deng Z, Osby M, Chen W, Xu HH

Sci Rep,

2015, 5:8643.


Differential responses of gut microbiota to the same prebiotic formula in oligotrophic and eutrophic batch fermentation systems

Long W, Xue Z, Zhang Q, Feng Z, Bridgewater L, Wang L, Zhao L, Pang X

Sci Rep,

2015, 5:13469.


Enhancing the light-driven production of D-lactate by engineering cyanobacterium using a combinational strategy

Li C, Tao F, Ni J, Wang Y, Yao F, Xu P

Sci Rep,

2015, 5:9777.


A filifactor alocis-centered co-occurrence group associates with periodontitis across different oral habitats

Chen H, Liu Y, Zhang M, Wang G, Qi Z, Bridgewater L, Zhao L, Tang Z, Pang X

Sci Rep,

2015, 5:9053.


Functional identification of a novel gene, moaE, for 3-Succinoylpyridine degradation in Pseudomonas putida S16

Jiang Y, Tang H, Wu G, Xu P

Sci Rep,

2015, 5:13464.


In vitro analysis of phosphorothioate modification of DNA reveals substrate recognition by a multiprotein complex

Cao B, Zheng X, Cheng Q, Yao F, Zheng T, Ramesh Babu I, Zhou H, Dedon P, You D

Sci Rep,

2015, 5:12513.


Mimicking a natural pathway for de novo biosynthesis: natural vanillin production from accessible carbon sources

Ni J, Tao F, Du H, Xu P

Sci Rep,

2015, 5:13670.


Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats

Zhang X, Zhao Y, Xu J, Xue Z, Zhang M, Pang X, Zhang X, Zhao L

Sci Rep,

2015, 5:14405.


The multiple DSF-family QS signals are synthesized from carbohydrate and branched-chain amino acids via the FAS elongation cycle

Zhou L, Yu Y, Chen X, Diab AA, Ruan L, He J, Wang H, He YW

Sci Rep,

2015, 5:13294.


A novel crosstalk between TLR4- and NOD2-mediated signaling in the regulation of intestinal inflammation

Kim H, Zhao Q, Zheng H, Li X, Zhang T, Ma X

Sci Rep,

2015, 5:12018.


Synergistic algicidal effect and mechanism of two diketopiperazines produced by Chryseobacterium sp. strain GLY-1106 on the harmful bloom-forming Microcystis aeruginosa

Guo X, Liu X, Pan J, Yang H

Sci Rep,

2015, 5:14720.


Sustainable production of valuable compound 3-succinoyl-pyridine by genetically engineering Pseudomonas putida using the tobacco waste.

Wang WW, Xu P, and Tang HZ

Sci Rep,

2015, 5:16411.


Characterization of pseudooxynicotine amine oxidase of Pseudomonas putida S16 that is crucial for nicotine degradation.

Hu HY, Wang WW, Tang HZ, and Xu P

Sci Rep,

2015, 5:17770.


A functional 4-hydroxybenzoate degradation pathway in the
is required for full

Wang JY, Zhou L, Chen B, Sun S, Zhang W, Ming Li M, Tang HZ,
Jiang BL, Tang JL & He YW

Sci Rep,

2015, 5:18456.


Real-time ArcGIS and heterotrophic plate count based chloramine disinfectant control in water distribution system

Bai X, Zhi X, Zhu H, Meng M, Zhang M

Water Res,

2015, 68:812-20.


Sparsomycin biosynthesis highlights unusual module architecture and processing mechanism in non-ribosomal peptide synthetase

Rui Z, Huang W, Xu F, Han M, Liu X, Lin S, Zhang W

ACS Chem Biol,

2015, 10(8):1765-9.


Mapping the resistance-associated mobilome of a carbapenem-resistant Klebsiella pneumoniae strain reveals insights into factors shaping these regions and facilitates generation of a 'resistance-disarmed' model organism

Bi D, Jiang X, Sheng ZK, Ngmenterebo D, Tai C, Wang M, Deng Z, Rajakumar K, Ou HY

J Antimicrob Chemother,

2015, 70(10):2770-4.


Crystal structure of PnpCD, a two-subunit Hydroquinone 1,2-Dioxygenase, reveals a novel structural class of Fe2+-dependent dioxygenases

Liu S, Su T, Zhang C, Zhang WM, Zhu D, Su J, Wei T, Wang K, Huang Y, Guo L, Xu S, Zhou NY, Gu L

J Biol Chem,

2015, 290(40):24547-60.


Multicomponent kinetic analysis and theoretical studies on the phenolic intermediates in the oxidation of eugenol and isoeugenol catalyzed by laccase

Qi YB, Wang XL, Shi T, Liu S, Xu ZH, Li X, Shi X, Xu P, Zhao YL

Phys Chem Chem Phys, 2015, 17(44):29597-607.


A facile method for controlling the reaction equilibrium of sphingolipid ceramide N-deacylase for lyso-glycosphingolipid production

Huang FT, Han YB, Feng Y, Yang GY

J Lipid Res,

2015, 56(9):1836-42.


Regulation of DNA phosphorothioate modifications by the transcriptional regulator DptB in Salmonella

Cheng Q, Cao B, Yao F, Li J, Deng Z, You D

Mol Microbiol,

2015, 97(6):1186-94.


Reciprocating free-flow isoelectric focusing device for preparative separation of proteins

Kong FZ, Yang Y, Wang Y, Li GQ, Li S, Xiao H, Fan LY, Liu SR, Cao CX

J Chromatogr A,

2015 27, 1422:318-24.


Target protein separation and preparation by free-flow electrophoresis coupled with charge-to-mass ratio analysis

Shen QY, Guo CG, Yan J, Zhang Q, Xie HY, Jahan S, Fan LY, Xiao H, Cao CX

J Chromatogr A,

2015, 1397:73-80.


A highly efficient three-phase single drop microextraction technique for sample preconcentration

Jahan S, Xie H, Zhong R, Yan J, Xiao H, Fan L, Cao C


2015, 140(9):3193-200.


The drinking water treatment process as a potential source of affecting the bacterial antibiotic resistance

Bai XH, Ma XL, Xu FM, Li J, Zhang H, Xiao X

Sci Total Environ,

2015, 533:24-31.


Actinomycetes from the South China Sea sponges: isolation, diversity, and potential for aromatic polyketides discovery

Sun W, Zhang F, He L, Karthik L, Li Z

Front Microbiol,

2015, 6:1048.


Bacteria in the injection water differently impacts the bacterial communities of production wells in high-temperature petroleum reservoirs

Ren H, Xiong S, Gao G, Song Y, Cao G, Zhao L, Zhang X

Front Microbiol,

2015, 6:505.


Interactions of Dnd proteins involved in bacterial DNA phosphorothioate modification

Xiong W, Zhao G, Yu H, He X

Front Microbiol,

2015, 6:1139.


Recombinant expression library of Pyrococcus furiosus constructed by high-throughput cloning: a useful tool for functional and structural genomics

Yuan H, Peng L, Han Z, Xie JJ, Liu XP

Front Microbiol,

2015, 6:943.


The regulatory function of LexA is temperature-dependent in the deep-sea bacterium Shewanella piezotolerans WP3

Jian H, Xiong L, He Y, Xiao X

Front Microbiol,

2015, 6:627.


Metagenome and metatranscriptome revealed a highly active and intensive Sulfur cycle in an oil-Immersed hydrothermal chimney in Guaymas Basin

He Y, Feng XY, Fang J, Zhang Y, Xiao X

Front Microbiol,

2015, 6:1236.


Test and evaluation of ff99IDPs force field for intrinsically disordered proteins

Ye W, Ji D, Wang W, Luo R, Chen HF

J Chem Inf Model,

2015, 55(5):1021-9.


The host genotype and environment affect strain types of Bifidobacterium longum subsp. longum Inhabiting the Intestinal tracts of twins

Zhang M, Hang X, Tan J, Yang H

Appl Environ Microb,

2015, 81(14):4774-81.


Identification of a specific maleate hydratase in the direct hydrolysis route of the gentisate pathway

Liu K, Xu Y, Zhou NY

Appl Environ Microb,

2015, 81(17):5753-60.


molecular mechanism of nicotine degradation by a newly isolated strain, Ochrobactrum sp. strain SJY1

Yu H, Tang H, Zhu X, Li Y, Xu P

Appl Environ Microb,

2015, 81(1):272-81.


Molybdenum-containing nicotine hydroxylase genes in a nicotine
degradation pathway that is a variant of the pyridine and
pyrrolidine pathways

Yu H, Tang H, Li Y, Xu P

Appl Environ Microb,

2015, 81(24):8330-8.


pSW2, a novel low-temperature-inducible gene expression vector based on a filamentous phage of the deep-sea bacterium Shewanella piezotolerans WP3

Yang XW, Jian HH, Wang FP

Appl Environ Microb,

2015, 81(16):5519-26.


Quantitative proteomic analysis of microdissected oral epithelium for cancer biomarker discovery

Xiao H, Langerman A, Zhang Y, Khalid O, Hu S, Cao CX, Lingen MW, Wong DT

Oral Oncol,

2015, 51(11):1011-9.


A tunable isoelectric focusing via moving reaction boundary for two-dimensional gel electrophoresis and proteomics

Guo CG, Shang Z, Yan J, Li S, Li GQ, Liu RZ, Qing Y, Fan LY, Xiao H, Cao CX


2015, 137:197-203.


Accumulation of yellow Monascus pigments by extractive fermentation in nonionic surfactant micelle aqueous solution

Xiong X, Zhang X, Wu Z, Wang Z

Appl Microbiol Biot,

2015, 99(3):1173-80.


Algicidal activity of Bacillus sp. Lzh-5 and its algicidal compounds against Microcystis aeruginosa

Li Z, Geng M, Yang H

Appl Microbiol Biot,

2015, 99(2):981-90.


Comprehensive characterization of sphingolipid ceramide N-deacylase for the synthesis and fatty acid remodeling of glycosphingolipids

Han YB, Wu L, Rich JR, Huang FT, Withers SG, Feng Y, Yang GY

Appl Microbiol Biot,

2015, 99(16):6715-26.


Crude oil degradation by bacterial consortia under four different redox and temperature conditions

Xiong S, Li X, Chen J, Zhao L, Zhang H, Zhang X

Appl Microbiol Biot,

2015, 99(3):1451-61.


Engineered biosynthesis of pimaricin derivatives with improved antifungal activity and reduced cytotoxicity

Qi Z, Kang Q, Jiang C, Han M, Bai L

Appl Microbiol Biot,

2015, 99(16):6745-52.


Functional gene-based discovery of phenazines from the actinobacteria associated with marine sponges in the South China Sea

Karuppiah V, Li Y, Sun W, Feng G, Li Z

Appl Microbiol Biot,

2015, 99(14):5939-50.


Metabolic engineering of Escherichia coli to enhance acetol production from glycerol

Yao R, Liu Q, Hu H, Wood TK, Zhang X

Appl Microbiol Biot,

2015, 99(19):7945-52.


Positive and negative regulation of GlnR in validamycin A biosynthesis by binding to different loci in promoter region

Qu S, Kang Q, Wu H, Wang L, Bai L

Appl Microbiol Biot,

2015, 99(11):4771-83.


Relationship between acid tolerance and cell membrane in Bifidobacterium, revealed by comparative analysis of acid-resistant derivatives and their parental strains grown in medium with and without Tween 80

Yang X, Hang X, Zhang M, Liu X, Yang H

Appl Microbiol Biot,

2015, 99(12):5227-36.


Destabilization of alzheimer's abeta42 protofibrils with a novel drug candidate wgx-50 by molecular dynamics Simulations

Fan HM, Gu RX, Wang YJ, Pi YL, Zhang YH, Xu Q, Wei DQ

J Phys Chem B,

2015, 119(34):11196-202.


Recognition mechanism between Lac repressor and DNA with correlation network analysis

Xu L, Ye W, Jiang C, Yang J, Zhang J, Feng Y, Luo R, Chen HF

J Phys Chem B,



Theoretical study on the relationship between Rp-phosphorothioation and base-step in S-DNA: based on energetic and structural analysis

Chen L, Wang XL, Shi T, Wu T, Deng Z, Zhao YL

J Phys Chem B,

2015, 119(2):474-81.


Active site loop conformation regulates promiscuous activity in a lactonase from Geobacillus kaustophilus HTA426

Zhang Y, An J, Yang GY, Bai A, Zheng B, Lou Z, Wu G, Ye W, Chen HF, Feng Y, Manco G

PloS One,

2015, 10(2):e0115130.


Elucidation of enzymatic mechanism of phenazine biosynthetic protein PhzF using QM/MM and MD simulations

Liu F, Zhao YL, Wang X, Hu H, Peng H, Wang W, Wang JF, Zhang X

PloS One,

2015, 10(9):e0139081.


Identification of the lomofungin biosynthesis gene cluster and associated flavin-dependent monooxygenase gene in Streptomyces lomondensis S015

Zhang C, Sheng C, Wang W, Hu H, Peng H, Zhang X

PloS One,

2015, 10(8):e0136228.


Mixed wastewater coupled with CO2 for microalgae culturing and nutrient removal

Yao L, Shi J, Miao X

PloS One,

2015, 10(9):e0139117.


Revealing the binding mode between respiratory syncytial virus fusion protein and benzimidazole-based inhibitors

Ji D, Ye W, Chen H

Mol Biosyst,

2015, 11(7):1857-66.


Preparation and characterization of yellow Monascus pigments

Zhong SJ, Zhang XH, Wang ZL.

Sep Purif Technol,

2015, 150:139-144


Design of hyperthermophilic lipase chimeras by key motif-directed recombination

Zhou X, Gao L, Yang G, Liu D, Bai A, Li B, Deng Z, Feng Y


2015, 16(3):455-62.


Kangiella profundi sp. nov., isolated from deep-sea sediment

Xu FD, Li XG, Xiao X, Xu J

Int J Syst Evol Microbiol. 2015, 65(7):2315-9.


Selectivity mechanism of ATP-competitive Inhibitors for PKB and PKA

Wu K, Pang J, Song D, Zhu Y, Wu C, Shao T, Chen H

Chem Biol Drug Des,

2015, 86(1):9-18.


Differences in acid tolerance between Bifidobacterium breve BB8 and its acid-resistant derivative B. breve BB8dpH, revealed by RNA-sequencing and physiological analysis

Yang X, Hang X, Tan J, Yang H


2015, 33:76-84.


Characterization of a novel thermostable patatin-like protein from a Guaymas basin metagenomic library

Fu L, He Y, Xu F, Ma Q, Wang F, Xu J


2015, 19(4):829-40.


(+)Terrein inhibits human hepatoma Bel7402 proliferation through cell cycle arrest

Zhang F, Mijiti M, Ding W, Song J, Yin Y, Sun W, Li Z

Oncol Rep,

2015, 33(3):1191-200.


Antitumor and antimetastatic activities of chloroform extract of medicinal mushroom Cordyceps taii in mouse models

Liu RM, Zhang XJ, Liang GY, Yang YF, Zhong JJ, Xiao JH

Bmc Complem Altern M,

2015, 15:216.


Erratum to: 'Antitumor and antimetastatic activities of chloroform extract of medicinal mushroom Cordyceps taii in mouse models'

Liu RM, Zhang XJ, Liang GY, Yang YF, Zhong JJ, Xiao JH

Bmc Complem Altern M,

2015, 15:284.


The alpha7 nAChR selective agonists as drug candidates for Alzheimer's disease

Fan H, Gu R, Wei D

Adv Exp Med Biol,

2015, 827:353-65.


An application of QM/MM simulation: the second protonation of cytochrome P450

Lian P, Wei D

Adv Exp Med Biol,

2015, 827:311-24.


Applications of rare event dynamics on the free energy calculations for membrane protein systems

Wang Y, Gu R, Fan H, Ulmschneider J, Wei D

Adv Exp Med Biol,

2015, 827:71-82.


Binding induced intrinsically disordered protein folding with molecular dynamics simulation

Chen H

Adv Exp Med Biol,

2015, 827:111-21.


Bioinformatics tools for discovery and functional analysis of single nucleotide polymorphisms

Li L, Wei D

Adv Exp Med Biol,

2015, 827:287-310.


Drug inhibition and proton conduction mechanisms of the influenza a M2 proton channel

Gu R, Liu LA, Wei D

Adv Exp Med Biol,

2015, 827:205-26.


Exploring the ligand-protein networks in traditional chinese medicine: current databases, methods and applications

Zhao M, Wei D

Adv Exp Med Biol,

2015, 827:227-57.


Human cytochrome P450 and personalized medicine

Chen Q, Wei D

Adv Exp Med Biol,

2015, 827:341-51.


Introduction to structural bioinformatics

Xu Q, Dai H, Zhao T, Wei D

Adv Exp Med Biol,

2015, 827:1-7.


Recent progress on structural bioinformatics research of cytochrome P450 and its impact on drug discovery

Zhang T, Wei D

Adv Exp Med Biol,

2015, 827:327-39.


A new alkaline lipase obtained from the metagenome of marine sponge Ircinia sp

Su J, Zhang F, Sun W, Karuppiah V, Zhang G, Li Z, Jiang Q

World J Microb Biot,

2015, 31(7):1093-102.


Two nucleoside receptors from Streptomyces coelicolor: expression of the genes and characterization of the recombinant proteins

Li F, Liang J, Wang W, Zhou X, Deng Z, Wang Z

Protein Expres Purif,

2015, 109:40-6.


Phylogenetic diversity of sulphate-reducing Desulfovibrio associated with three South China Sea sponges

Zhang D, Sun W, Feng G, Zhang F, Anbuchezhian R, Li Z, Jiang Q

Lett Appl Microbiol,

2015, 60(5):504-12.


Overexpression of afsR and optimization of metal chloride to improve lomofungin production in Streptomyces lomondensis S015

Wang W, Wang H, Hu H, Peng H, Zhang X

J Microbiol Biotechn

2015, 25(5):672-80.


[An efficient genetic knockout system based on linear DNA fragment homologous recombination for halophilic archaea]

Wang XL, Jiang C, Liu JH, Liu XP

Yi chuan,

2015, 37(4):388-95.


Isolation and structural identification of two bioactive phenazines from
Streptomyces griseoluteus P510

Luo Q, Hu HB, Peng HS, Zhang XH, Wang W

Chinese J Chem Eng,

2015, 699–703


Detection of erm(X)- mediated antibiotic resistance in Bifidobacterium longum subsp. longum.

Luo C, Hang X, Liu X, Zhang M, Yang X, Yang H.

Ann Microbiol,

2015, 65:1985–1991


Improved feature-based prediction of SNPs in human cytochrome P450 enzymes

Li L, Xiong Y, Zhang ZY, Guo Q, Xu Q, Liow HH, Zhang YH, Wei DQ

Interdiscip Sci,

2015, 7(1):65-77.


Molecular dynamics simulation studies of the wild type and E92Q/N155H mutant of Elvitegravir-resistance HIV-1 integrase

Chen Q, Cheng X, Wei D, Xu Q

Interdiscip Sci,

2015, 7(1):36-42.


Crystallization and preliminary X-ray analysis of the type IV restriction endonuclease ScoMcrA from Streptomyces coelicolor, which cleaves both Dcm-methylated DNA and phosphorothioated DNA

Liu G, Zhang Z, Zhao G, Deng Z, Wu G, He X

Acta Crystallogr F,

2015, 71(Pt 1):57-60.


Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences

Cao B, Chen C, DeMottMS, Cheng QX, Clark TA, Xiong XL, Zheng XQ, Zhou XF, Deng ZX, … You DL, Wang LR,Chen S, Dedon PC

Nat Commun, 2014, 5:3591


Microbial lactate utilization: Enzymes, pathogenesis, and regulation

Jiang TY, Gao C, Ma CQ, Xu P

Trends Microbiol, 2014, 22(10):589-599


Structure of the N-glycosidase MilB in complex with hydroxymethyl CMP reveals its Arg23 specifically recognizes the substrate and controls its entry

Zhao G, Wu G, Zhang Y, Liu G, Han TS, Deng ZX, He XY

Nucleic Acids Res, 2014, 42(12):8115-8124


Genetic and functional properties of uncultivated MCG archaea assessed by metagenome and gene expression analyses

Meng J, Xu J, Qin D, He Y, Xiao X, Wang FP

Isme J, 2014, 8(3):650-659


Methanotrophic archaea possessing diverging methane-oxidizing and electron-transporting pathways

Wang FP, Zhang Y, Chen Y, He Y, Qi J, Hinrichs KU, Zhang XX, Xiao X, Boon N

Isme J, 2014, 8(5):1069-1078


Biomineralization mediated by anaerobic methane-consuming cell consortia

Chen Y, Li YL, Zhou GT, Li H, Lin YT, Xiao X, Wang FP

Sci Rep, 2014, 16(4):5696


Green strategy from waste to value-added-chemical production: Efficient biosynthesis of 6-hydroxy-3-succinoyl-pyridine by an engineered biocatalyst

Yu H, Tang HZ, Xu P

Sci Rep, 2014, 23(4):5397


Metabolic profiles of prokaryotic and eukaryotic communities in deep-sea sponge Lamellomorpha sp indicated by metagenomics

Li ZY, Wang YZ, He LM, Zheng HJ

Sci Rep, 2014, 27(4):3895


Genomic analysis of thermophilic Bacillus coagulans strains: Efficient producers for platform bio-chemicals

Su F, Xu P

Sci Rep, 2014, 29(4):3926


Hydrophobic drug-triggered self-assembly of nanoparticles from silk-elastin-like protein polymers for drug delivery

Xia XX, Wang M, Lin YA, Xu QB, Kaplan DL

Biomacromolecules, 2014, 15(3):908-914


Structural insights into the specific recognition of N-heterocycle biodenitrogenation-derived substrates by microbial amide hydrolases

Wu G, Chen DD, Tang HZ, Ren YL, Chen QH, Lv Y, Zhang ZY, Zhao YL, Yao YX, Xu P

Mol Microbiol, 2014, 91(5):1009-1021


An unusual repressor controls the expression of a crucial nicotine-degrading gene cluster in Pseudomonas putida S16

Wang LJ, Tang HZ, Yu H, Yao YX, Xu P

Mol Microbiol, 2014, 91(6):1252-1269


Pathological phenotypes and in vivo DNA cleavage by unrestrained activity of a phosphorothioate- based restriction system in Salmonella

Cao B, Cheng QX, Gu C, Yao F, DeMott MS, Zheng XQ, Deng ZX, Dedon PC, You DL

Mol Microbiol, 2014, 93(4):776-785


Efficient production of L-lactic acid using co-feeding strategy based on cane molasses/glucose carbon sources

Xu K, Xu P

Bioresour Technol, 2014, 15323-29


Efficient calcium lactate production by fermentation coupled with crystallization-based in situ product removal

Xu K, Xu P

Bioresour Technol, 2014, 16333-39


Efficient production of 2,3-butanediol from corn stover hydrolysate by using a thermophilic Bacillus licheniformis strain

Li LX, Li K, Wang K, Chen C, Gao C, Ma CQ, Xu P

Bioresour Technol, 2014, 170256-261


Biodiesel quality and biochemical changes of microalgae Chlorella pyrenoidosa and Scenedesmus obliquus in response to nitrate levels

Wu HQ, Miao XL

Bioresour Technol, 2014, 170421-427


Induction of ganoderic acid biosynthesis by Mn2+ in static liquid cultivation of Ganoderma lucidum

Xu YN, Xia XX, Zhong JJ

Biotechnol Bioeng, 2014, 111(11):2358-2365


New in situ capture quantitative (real-time) reverse transcription-PCR method as an alternative approach for determining inactivation of tulane virus

Wang DP, Xu SX, Yang D, Young GM, Tian P

Appl Microbiol Biotechnol, 2014, 80(7):2120-2124


Genetically engineered Pichia pastoris yeast for conversion of glucose to xylitol by a single-fermentation process

Cheng HR, Lv JY, Wang HW, Wang B, Li ZL, Deng ZX

Appl Microbiol Biotechnol, 2014, 98(8):3539-3552


Significance of agitation-induced shear stress on mycelium morphology and lavendamycin production by engineered Streptomyces flocculus

Xia X, Lin SJ, Xia XX, Cong FS, Zhong JJ

Appl Microbiol Biotechnol, 2014, 98(10):4399-4407


A freshwater bacterial strain, Shewanella sp. lzh-2, isolated from lake taihu and its two algicidal active substances, hexahydropyrrolo 1,2-a pyrazine-1,4-dione and 2, 3-indolinedione

Li ZH, Lin SQ, Liu XL, Tan J, Pan JL, Yang H

Appl Microbiol Biotechnol, 2014, 98(10):4737-4748


Marine actinobacteria associated with marine organisms and their potentials in producing pharmaceutical natural products

Valliappan K, Sun W, Li ZY

Appl Microbiol Biotechnol, 2014, 98(17):7365-7377


Enhanced production of validamycin A in Streptomyces hygroscopicus 5008 by engineering validamycin biosynthetic gene cluster

Zhou TC, Kim BG, Zhong JJ

Appl Microbiol Biotechnol, 2014, 98(18):7911-7922


Retardation signal for fluorescent determination of total protein content via rapid and sensitive chip moving reaction boundary electrophoretic titration

Wang HY, Shi YT, Yan J, Dong JY, Li S, Xiao H, Xie HY, Fan LY, Cao CX

Anal Chem, 2014, 86(6):2888-2894


A new strategy for highly efficient single-drop microextraction with a liquid-gas compound pendant drop

Xie HY, Yan J, Jahan S, Zhong R, Fan LY, Xiao H, Jin XQ, Cao CX

Analyst, 2014, 139(10):2545-2550


Characterization of an algicidal bacterium Brevundimonas J4 and chemical defense of Synechococcus sp. BN60 against bacterium J4

Lin SQ, Pan JL, Li ZH, Liu XL, Tan J,Yang H

Harmful Algae, 2014, 371-7


Physiological and biochemical characterization of a novel nicotine-degrading bacterium Pseudomonas geniculata N1

Liu YH, Wang LJ, Huang KM, Wang WW, Nie XL, Jiang Y, Li PP, Liu SS, Xu P, Tang HZ

PLoS One, 2014, 9(1):e84399


An improved single cell ultrahigh throughput screening method based on in vitro compartmentalization

Ma FQ, Xie Y, Huang C, Feng Y, Yang GY

PLoS One, 2014, 9(2):e89785


Reaction kinetics for the biocatalytic conversion of phenazine-1-carboxylic acid to 2-hydroxyphenazine

Chen MM, Cao HX, Peng HS, Hu HB, Wang W, Zhang XH

PLoS One, 2014, 9(6):e98537


Characterization of the xiamenmycin biosynthesis gene cluster in Streptomyces xiamenensis 318

Yang Y, Fu L, Zhang JL, Hu LH, Xu , Xu J

PLoS One, 2014, 9(6):e99537


Betaine and beet molasses enhance L-lactic acid production by Bacillus coagulans

Xu K, Xu P

PLoS One, 2014, 9(6):e100731


Characterization of the medium- and long-chain n-alkanes degrading Pseudomonas aeruginosa strain SJTD-1 and its alkane hydroxylase genes

Liu H, Xu J, Liang RB, Liu JH

PLoS One, 2014, 9(8):e105506


Mutation of a Salmonella serogroup-C1-specific gene abrogates O7-antigen biosynthesis and triggers nacl-dependent motility deficiency

Zhou XJ, Liu B, Shi CL, Shi XM

PLoS One, 2014, 9(9):e106708


Stratified community responses to methane and sulfate supplies in mud volcano deposits: Insights from an in vitro experiment

Zhang Y, Maignien L, Stadnitskaia A, Boeckx P, Xiao X, Boon N

PLoS One, 2014, 9(11):e113004


Glycerol dehydrogenase plays a dual role in glycerol metabolism and 2,3-butanediol formation in Klebsiell pneumoniae

Wang Y, Tao F, Xu P

J Biol Chem, 2014, 289(9):6080-6090


Enhanced enzyme kinetic stability by increasing rigidity within the active site

Xie Y, An J, Yang GY, Wu G, Zhang Y, Cui L, Feng Y

J Biol Chem, 2014, 289(11):7994-8006


AvrXa7-Xa7 mediated defense in rice can be suppressed by transcriptional activator-like effectors TAL6 and TAL11a from Xanthomonas oryzae pv. oryzicola

Ji ZY, Xiong L, Zou LF, Li YR, Ma WX, Liu L, Zakria M, Ji GH, Chen GY

Mol Plant-Microbe Interact, 2014, 27(9):983-995


Features of S-nitrosylation based on statistical analysis and molecular dynamics simulation: Cysteine acidity, surrounding basicity, steric hindrance and local flexibility

Cheng SL, Sh iT, Wang XL, Liang J, Wu HY, Xie L, Li YX, Zhao YL

Mol Biosyst, 2014, 10(10):2597-2606


A recombinant adenovirus expressing CFP10, ESAT6, Ag85A and Ag85B of Mycobacterium tuberculosis elicits strong antigen-specific immune responses in mice

Li W, Deng GC, Li M, Zeng J, Zhao LP, Liu XM, Wang YJ

Mol Immunol, 2014, 62(1):86-95


New force field on modeling intrinsically disordered proteins

Wang W, Ye W, Jiang C, Luo R, Chen HF

Chem Biol Drug Des, 2014, 84(3):253-269


Analysis of Streptomyces coelicolor membrane proteome using two-dimensional native/native and native/sodium dodecyl sulfate gel electrophoresis

Li F, Liang J, Wang W, Zhou X, Deng Z, Wang Z

Anal Biochem, 2014, 465C:148-155


Purification and characterization of a thermostable aliphatic amidase from the hyperthermophilic archaeon Pyrococcus yayanosii CH1

Fu L, Li XG, Xiao X, Xu J

Extremophiles, 2014, 18(2):429-440


Purification, crystallization and preliminary X-ray analysis of the inverse F-BAR domain of the human srGAP2 protein

Wang HP, Zhang Y, Zhang ZY, Jin WL, Wu G

Acta Crystallogr F-Struct Biol Cryst Commun, 2014, 70123-126


X-ray structure of a Hg2+ complex of mercuric reductase (Mera):And QM/MM study of Hg2+ transfer between the C-terminal and buried catalytic site cysteine pairs

Lian H, Guo HB,   Riccardi D,   Dong AP, Jerry M Parks,  Xu Q, Emil F Pai,Susan M Miller,Wei DQ, Jeremy C Smith, Guo H

Biochemistry, 2014,25;53(46):7211-7222


Crystal structure of dszc from Rhodococcus sp XP at 179 angstrom

Liu SH, Zhang CG, Su TT, Wei TD, Zhu DY, Wang K, Huang Y, Dong YH, Yin K, Xu SJ, Xu P, Gu LC

Proteins, 2014, 82(9):1708-1720


Moving interaction boundary electrophoresis and its selective focusing of target guest molecule norfloxacin in urine by a cyclodextrin host

Fan LY, Luo XJ, Li S, Zhang W, Cao CX

Anal Methods, 2014, 6(12):4360-4365


Novel pyrrolobenzoxaboroles: Design, synthesis, and biological evaluation against Trypanosome brucei

Wu PH, Zhang J, Meng QQ, Nare B, Jacobs RT, Zhou HC

Eur J Med Chem, 2014, 81:59-75


A new glutarimide derivative from marine sponge-derived Streptomyces anulatus S71

Sun DD, Sun W, Yu YX, Li ZY, Deng ZX, Lin SJ

Nat Prod Res, 2014, 28(19):1602-1606


Influence of counteranions on catalytic ability of immobilized laccase in cu-alginate matrices: Inhibition of chloride and activation of acetate

Pan T, Sun YJ, Wang XL, Shi T, Zhao YL

Chinese Chem Lett, 2014, 25(7):983-988


Theoretical studies of the binding-affinity and reactivity between laccase and phenolic substrates

Qi YB, Zhu JR, Sun YJ, Du Y, Chu JJ, Shi T, Zhao YL, Wang XL

Chem J Chin Univ-Chin, 2014, 35(4):776-783


Theoretical studies on the mechanism, enantioselectivity, and axial ligand effect of a ru(salen)-catalyzed asymmetric cyclopropanation reaction

Shi T, Luo Y, Wang XL, Lu SY, Zhao YL, Zhang J

Organometallics, 2014, 33(14):3673-3682


Advance in the research on quinomycins biosynthesis

Zhang C, Kong LX, Lei X, Deng ZX, You DL

Chinese J Org Chem, 2014, 34(6):1240-1252


Transmembrane permeation mechanism of charged methyl guanidine

Wang YK, Hu D, Wei DQ

J Chem Theory Comput, 2014, 10(4):1717-1726


Specific recognition mechanism between RNA and KH3 domain of nova-2 protein

Yu QF, Ye W, Jiang C, Luo R, Chen HF

J Phys Chem B, 2014, 118(43):12426–12434


Transferring of red monascus pigments from nonionic surfactant to hydrophobic ionic liquid by novel microemulsion extraction

Shen LJ, Zhang XH, Liu MZ, Wang ZL

Separation and purification technology, 2014, 138:34-40


A fullerene colloidal suspension stimulates the growth and denitrification ability of wastewater treatment sludge-derived bacteria

Huang F, Ge L, Zhang B, Wang Y, Tian H, Zhao LP, He YL, Zhang XJ

Chemosphere, 2014, 108411-417


Phenotypic and genotypic antimicrobial resistance traits of foodborne Staphylococcus aureus isolates from Shanghai

Xu J, Shi CL, Song MH, Xu XB, Yang PY, Paoli G, Shi XM

J Food Sci, 2014, 79(4):M635-M642


Impact of sod on the expression of stress-related genes in Listeria monocytogenes 4b G with/without paraquat treatment

Suo YJ, Liu YH, Zhou XJ, Huang YY, Shi CL, Matthews K, Shi XM

J Food Sci, 2014, 79(9):M1745-M1749


Development of a sigde-based real-time reverse-transcriptase PCR for the detection of viable Salmonella enterica

Zhou M, Yang JL, Zhou XJ, Liu B, Liu DX, Yuan CG, He YP, Pan LW, Shi XM

Foodborne Pathog Dis, 2014, 11(7):537-544


HrcT is a key component of the type III secretion system in Xanthomonas spp and also regulates the expression of the key hrp transcriptional activator Hrpx

Liu ZY, Zou LF, Xue B, Cai LL, Ma WX, Xiong L, Ji ZY, Chen GY

Appl Environ Microbiol, 2014, 80(13):3908-3919


Biosynthesis of the beta-methylarginine residue of peptidyl nucleoside arginomycin in Streptomyces arginensis NRRL 15941

Feng J, Wu J, Gao J, Xia ZG, Deng ZX, He XY

Appl Environ Microbiol, 2014, 80(16):5021-5027


Efficient simultaneous saccharification and fermentation of inulin to 2,3-butanediol by thermophilic Bacillus licheniformis ATCC 14580

Li LX, Chen C, Li K, Wang Y, Gao C, Ma CQ, Xu P

Appl Environ Microbiol, 2014, 80(20):6458-6464


Operon for biosynthesis of lipstatin, the beta-lactone inhibitor of human

Bai TL, Zhang DZ,  Lin SJ, Long QS,   Wang YM, Ou HY,  Kang QJ, Deng ZX,  Wen L, Tao MF

Appl Environ Microbiol, 2014, 80(24):7473-7483


Gut microbiota-based translational biomarkers to prevent metabolic syndrome via nutritional modulation

Xiao SM, Zhao LP

FEMS Microbiol Ecol, 2014, 87(2):303-314


A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome

Xiao SM, Fei N, Pang XY, Shen J, Wang LH, Zhang BR, Zhang MH, Zhang XJ, …Feng J, Yan FY, Zhao NS, Liu JQ, Long WM, Zhao LP

FEMS Microbiol Ecol, 2014, 87(2):357-367


Pyrosequencing reveals diverse microbial community associated with the Zoanthid Palythoa australiae from the South China sea

Sun W, Zhang FL, He LM, Li ZY

Microb Ecol, 2014, 67(4):942-950


Comparisons of the fungal and protistan communities among different marine sponge holobionts by pyrosequencing

He LM, Liu F, Karuppiah V, Ren Y, Li ZY

Microb Ecol, 2014, 67(4):951-961


Seasonal dynamics and diversity of bacteria in retail oyster tissues

Wang DP, Zhang Q, Cui Y, ShiXM

Int J Food Microbiol, 2014, 173:14-20


Identification and characterization of the biosynthetic gene cluster of polyoxypeptin A, a potent apoptosis inducer

Du YH, Wang YM, Huang TT, Tao MF, Deng ZX, Lin SJ

BMC Microbiol, 2014, 14:30


Predicting protein-ligand interactions based on chemical preference features with its application to new D-amino acid oxidase inhibitor discovery

Zhao MZ, Chang HT, Zhou Q, Zeng T, Shih CS, Liu ZP, Chen LN, Wei DQ

Curr Pharm Design, 2014, 20(32):5202-5211


Catalytic mechanism and origin of high activity of cellulase TmCel12A at high temperature: A quantum mechanical/molecular mechanical study

Lian P, Guo HB, Smith JC, Wei DQ, Guo H

Cellulose, 2014, 21(2):937-949


How reliable are molecular dynamics simulations of membrane active antimicrobial peptides?

Wang YK, Zhao TZ, Wei DQ, Strandberg E, Ulrich AS, Ulmschneider JP

Biochim Biophys Acta-Biomembr, 2014, 9:2280-2288


A hadoop-based method to predict potential effective drug combination

Sun YF, Xiong Y, Xu Q,  Wei DQ

Biomed Res Int, 2014:196858


The gut microbiota and obesity: from correlation to causality

Zhao LP

Nat Rev Microbiol,

2013, 11(9):639-47.


Stereospecific biosynthesis of β-methyl tryptophan from L-tryptophan features a stereochemical switch.

Zou y, Fang Q, Yin H, Liang Z, Kong D, Bai L, Deng Z, Lin S

Angew Chem Int Ed ,

2013, 52:12951-955.


Characterization of streptonigrin biosynthesis reveals a cryptic carboxyl methylation and an unusual oxidative cleavage of a N-C bond

Xu F, Kong DK, He XY, Zhang Z, Han M, Xie XQ, Wang P, Cheng HR, Tao MF, Zhang LP, Deng ZX, Lin SJ

J Am Chem Soc,

2013, 135(5):1739-48.


Structural modulation of gut microbiota in life-long calorie-restricted mice

Zhang CH, Li SF, Yang L, Huang P, Li WJ, Wang SY, Zhao GP, Zhang MH, Pang XY, Yan Z, Liu Y, Zhao LP

Nat Commun,

2013, 4:2163.


Structural insight into the mutual recognition and regulation between suppressor of fused and Gli/Ci

Zhang Y, Fu L, Qi XL, Zhang ZY, Xia YX, Jia JH, Jiang J, Zhao Y, Wu G

Nat Commun,

2013, 4:2608.


Structural and energetic analysis of drug inhibition of the influenza A M2 proton channel

Gu RX, Liu LA, Wei DQ

Trends Pharmacol Sci,

2013, 34(10):571-80.


An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice

Fei N, Zhao LP

Isme J,

2013, 7(4):880-84.


Systematic unraveling of the unsolved pathway of nicotine degradation in Pseudomonas.

Tang HZ., Wang LJ., Wang WW., Yu H., Zhang KZ., Yao YX., and Xu P.*

PloS Genet,

2013. 9(10):e1003923.


RecJ-like protein from Pyrococcus furiosus has 3'-5' exonuclease activity on RNA: implications for proofreading of 3'-mismatched RNA primers in DNA replication

Yuan H, Liu XP, Han Z, Allers T, Hou JL, Liu JH

Nucleic Acids Res,

2013, 41(11):5817-26.


SecReT4: a web-based bacterial type IV secretion system resource

Bi DX, Liu LM, Tai C, Deng ZX, Rajakumar K, Ou HY

Nucleic Acids Res,

2013, 41(D1):D660-D65.


Metabolic and pathway engineering to influence native and altered erythromycin production through E. coli

Jiang M, Pfeifer BA

Metab Eng,

2013, 19:42-49.


Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens

Zhu T, Cheng XQ, Liu YT, Deng ZX, You DL

Metab Eng,

2013, 19:69-78.


Tandem modifications of an epoxyquinone C7N pharmacophore

Bai LQ

Chem Biol,

2013, 20(7):859-60.


Simple boric acid-based fluorescent focusing for sensing of glucose and glycoprotein via multipath moving supramolecular boundary electrophoresis chip

Dong JY, Li S, Wang HY, Meng QH, Fan LY, Xie HY, Cao CX, Zhang WB

Anal Chem,

2013, 85(12):5884-91.


Phylogenetically diverse endozoic fungi in the South China Sea sponges and their potential in synthesizing bioactive natural products suggested by PKS gene and cytotoxic activity analysis

Yu ZS, Zhang BH, Sun W, Zhang FL, Li ZY

Fungal Divers,

2013, 58(1):127-41.


The diffusible factor synthase XanB2 is a bifunctional chorismatase that links the shikimate pathway to ubiquinone and xanthomonadins biosynthetic pathways

Zhou L, Wang JY, Wang JH, Poplawsky A, Lin SJ, Zhu BS, Chang CQ, Zhou TL, Zhang LH, He YW

Mol Microbiol,

2013, 87(1):80-93.


Structural and computational studies of the maleate isomerase from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside

Chen DD, Tang HZ, Lv Y, Zhang ZY, Shen KL, Lin K, Zhao YL, Wu G, Xu P

Mol Microbiol,

2013, 87(6):1237-44.


Efficient ethanol production from corncob residues by repeated fermentation of an adapted yeast

Fan C, Qi K, Xia XX, Zhong JJ

Bioresour Technol,

2013, 136:309-15.


Production of acetol from glycerol using engineered Escherichia coli

Zhu HL, Yi XY, Liu Y, Wood TK, Hu HB, Zhang XH

Bioresour Technol,

2013, 149:238-43.


Comparative genomic analysis of four representative plant growth-promoting rhizobacteria in Pseudomonas

Shen XM, Hu HB, Peng HS, Wang W, Zhang XH

BMC Genomics,

2013, 14:271.


A visual detection of protein content based on titration of moving reaction boundary electrophoresis

Wang HY, Guo CY, Guo CG, Fan LY, Zhang L, Cao CX

Anal Chim Acta,

2013, 774:92-99.


A rapid method for the detection of foodborne pathogens by extraction of a trace amount of DNA from raw milk based on amino-modified silica-coated magnetic nanoparticles and polymerase chain reaction

Bai YL, Song MH, Cui Y, Shi CL, Wang DP, Paoli GC, Shi XM

Anal Chim Acta,

2013, 787:93-101.


The rice bacterial pathogen Xanthomonas oryzae pv. oryzae produces 3-hydroxybenzoic acid and 4-hydroxybenzoic acid via XanB2 for use in xanthomonadin, ubiquinone, and exopolysaccharide biosynthesis

Zhou L, Huang TW, Wang JY, Sun S, Chen GY, Poplawsky A, He YW

Mol Plant-Microbe Interact,

2013, 26(10):1239-48.


Impact of resistance mutations on inhibitor binding to HIV-1 integrase

Chen Q, Buolamwini JK, Smith JC, Li A, Xu Q, Cheng X, Wei DQ

J Chem Inf Model,

2013, 53(12):3297-307.


Chlamydophila pneumoniae endonuclease IV prefers to remove mismatched 3 ' ribonucleotides: Implication in proofreading mismatched 3 '-terminal nucleotides in short-patch repair synthesis

Xie JJ, Liu XP, Han Z, Yuan H, Wang Y, Hou JL, Liu JH

DNA Repair,

2013, 12(2):140-47.


Harnessing the potential of halogenated natural product biosynthesis by mangrove-derived actinomycetes

Li X-G, Tang X-M, Xiao J, Ma G-H, Xu L, Xie S-J, Xu M-J, Xiao X, Xu J

Marine drugs,

2013, 11(10):3875-90.


Identification of two novel anti-fibrotic benzopyran compounds produced by engineered strains derived from Streptomyces xiamenensis M1-94P that originated from deep-sea sediments

You Z-Y, Wang Y-H, Zhang Z-G, Xu M-J, Xie S-J, Han T-S, Feng L, Li X-G, Xu J

Marine drugs,

2013, 11(10):4035-49.


Model creation of moving redox reaction boundary in agarose gel electrophoresis by traditional potassium permanganate method

Xie HY, Liu Q, Li JH, Fan LY, Cao CX


2013, 138(4):1137-40.


Determination of free acidic and alkaline residues of protein via moving reaction boundary titration in microdevice electrophoresis

Wang HY, Li S, Tang YY, Dong JY, Fan LY, Cao CX


2013, 138(12):3544-51.


Theoretical and experimental studies on isotachophoresis in multi-moving chelation boundary system formed with metal ions and EDTA

Zhang W, Guo CG, Fan LY, Cao CX


2013, 138(17):5039-51.


Mathematical model and dynamic computer simulation on free flow zone electrophoresis

Zhang J, Yan J, Li S, Pang B, Guo CG, Cao CX, Jin XQ


2013, 138(19):5734-44.


Kink turn sRNA folding upon L7Ae binding using molecular dynamics simulations

Ye W, Yang JX, Yu QF, Wang W, Hancy J, Luo R, Chen HF

Phys Chem Chem Phys,

2013, 15(42):18510-22.


A trans-acting ketoreductase in biosynthesis of a symmetric polyketide dimer SIA7248

Zou Y, Yin HX, Kong DK, Deng ZX, Lin SJ


2013, 14(6):679-83.


In vitro characterization of echinomycin biosynthesis: formation and hydroxylation of L-tryptophanyl-S-enzyme and oxidation of (2S,3S) beta- hydroxytryptophan

Zhang C, Kong LX, Liu Q, Lei X, Zhu T, Yin J, Lin BR, Deng ZX, You DL

PLoS One,

2013, 8(2):e56772.


Global conformational selection and local induced fit for the recognition between intrinsic disordered p53 and CBP

Yu QF, Ye W, Wang W, Chen HF

PLoS One,

2013, 8(3):e59627.


Phylogenetically diverse ureC genes and their expression suggest the urea utilization by bacterial symbionts in marine sponge Xestospongia testudinaria

Su J, Jin LL, Jiang Q, Sun W, Zhang FL, Li ZY

PLoS One,

2013, 8(5):e64848.


The different potential of sponge bacterial symbionts in N-2 release indicated by the phylogenetic diversity and abundance analyses of denitrification genes, nirK and nosZ

Zhang X, He LM, Zhang FL, Sun W, Li ZY

PLoS One,

2013, 8(6):e65142.


Characterization of two Streptomyces enzymes that convert ferulic acid to vanillin

Yang WW, Tang HZ, Ni J, Wu QL, Hua DL, Tao F, Xu P

PLoS One,

2013, 8(6):e67339.


Discovery and characterization of BlsE, a radical S-adenosylL-methionine decarboxylase involved in the blasticidin S biosynthetic pathway

Feng J, Wu J, Dai N, Lin SJ, Xu HH, Deng ZX, He XY

PLoS One,

2013, 8(7):e68545.


The regulatory role of ferric uptake regulator (Fur) during anaerobic respiration of Shewanella piezotolerans WP3

Yang XW, He Y, Xu J, Xiao X, Wang FP

PLoS One,

2013, 8(10):e75588.


Identification of Mur34 as the novel negative regulator responsible for the biosynthesis of muraymycin in Streptomyces sp NRRL30471

Xu DM, Liu G, Cheng L, Lu XH, Chen WQ, Deng ZX

PLoS One,

2013, 8(10):e76068.


Structural comparison of the wild-type and drug-resistant mutants of the influenza A M2 proton channel by molecular dynamics simulations

Gu RX, Liu LA, Wang YH, Xu Q, Wei DQ

J Phys Chem B,

2013, 117(20):6042-51.


Transcriptome analysis of candidate genes and signaling pathways associated with light-induced brown film formation in Lentinula edodes

Tang LH, Jian HH, Song CY, Bao DP, Shang XD, Wu DQ, Tan Q, Zhang XH

Appl Microbiol Biotechnol,

2013, 97(11):4977-89.


Streptomyces lividans blasticidin S deaminase and its application in engineering a blasticidin S-producing strain for ease of genetic manipulation

Li L, Wu J, Deng ZX, Zabriskie TM, He XY

Appl Environ Microbiol,

2013, 79(7):2349-57.


Role of filamentous phage SW1 in regulating the lateral flagella of Shewanella piezotolerans strain WP3 at low temperatures

Jian HH, Xiao X, Wang FP

Appl Environ Microbiol,

2013, 79(22):7101-09.


Novel moving reaction boundary-induced stacking and separation of human hemoglobins in slab polyacrylamide gel electrophoresis

Tang YY, Wang HY, Chen L, Li S, Guo CG, Fan HZ, Cao CX, Fan LY

Anal Bioanal Chem,

2013, 405(26):8587-95.


Induced effect of  Na plus on ganoderic acid biosynthesis in static liquid culture of Ganoderma lucidum via calcineurin signal transduction

Xu YN, Xia XX, Zhong JJ

Biotechnol Bioeng,

2013, 110(7):1913-23.


Exogenous 1, 4butyrolactone stimulates Afactorlike cascade and validamycin biosynthesis in Streptomyces hygroscopicus 5008

Tan GY, Bai L, Zhong JJ

Biotechnol Bioeng,

2013, 110(11):2984-93.


Conformational selection and induced fit in specific antibody and antigen recognition: SPE7 as a case study

Wang W, Ye W, Yu QF, Jiang C, Zhang J, Luo R, Chen HF

J Phys Chem B,

2013, 117(17):4912-23.


Car-Parrinello molecular dynamics/molecular mechanics (CPMD/MM) simulation study of coupling and uncoupling mechanisms of cytochrome P450cam

Lian P, Li J, Wang DQ, Wei DQ

J Phys Chem B,

2013, 117(26):7849-56.


Mathematical model and computer simulation on moving precipitate boundary electrophoresis for offline sample pre- concentration of heavy metal ion

Chang J, Zhang J, Wang HY, Fan LY, Fan YP, Li S, Cao CX


2013, 103:314-21.


Stump-like mathematical model and computer simulation on dynamic separation of capillary zone electrophoresis with different sample injections

Zhang J, Huang QF, Jin J, Chang J, Li S, Fan LY, Cao CX


2013, 105:278-86.


Study on stability mechanism of immobilized pH gradient in isoelectric focusing via Svensson-Tiselius differential equation and moving reaction boundary

Guo C-G, Li S, Wang H-Y, Zhang D, Li G-Q, Zhang J, Fan L-Y, Cao C-X


2013, 111:20-7.


Impact of glutathione-HbA1c on HbA1c measurement in diabetes diagnosis via array isoelectric focusing, liquid chromatography, mass spectrometry and ELISA.

Qi J, Shao CL, Li ZY, Gan LS, Fu XM, Bian WT, Zhao HY, Wang CY.




A stable and high-resolution isoelectric focusing capillary array device for micropreparative separation of proteins.

Li S, Dong JY, Guo CG, Wu YX, Zhang W, Fan LY, Cao CX, Zhang WB.


2013, 116:259-265


Catalytic mechanism and origin of high activity of cellulase TmCel12A at high temperature: a quantum mechanical/molecular mechanical study

Lian P, Guo H-B, Smith JC, Wei D-Q, Guo H


2013, 1-13.


Site selectivity for protein tyrosine nitration: insights from features of structure and topological network

Cheng SL, Lian BF, Liang J, Shi T, Xie L, Zhao YL

Mol Biosyst,

2013, 9(11):2860-68.


In vivo investigation of the substrate recognition capability and activity affecting amino acid residues of glycosyltransferase FscMI in the biosynthesis of candicidin

Lei X, Kong LX, Zhang C, Liu Q, Yao F, Zhang WK, Deng ZX, You DL

Mol Biosyst,

2013, 9(3):422-30.


Structural changes of gut microbiota in a rat non-alcoholic fatty liver disease model treated with a Chinese herbal formula

Yin XC, Peng JH, Zhao LP, Yu YP, Zhang X, Liu P, Feng Q, Hu YY, Pang XY

Syst Appl Microbiol,

2013, 36(3):188-96.


Phylogenetic diversity of Actinobacteria associated with soft coral Alcyonium gracllimum and stony coral Tubastraea coccinea in the east China sea

Yang S, Sun W, Tang C, Jin LL, Zhang FL, Li ZY

Microb Ecol,

2013, 66(1):189-99.


The ammonia oxidizing and denitrifying prokaryotes associated with sponges from different sea areas

Han MQ, Li ZY, Zhang FL

Microb Ecol,

2013, 66(2):427-36.


Fast and selective determination of total protein in milk powder via titration of moving reaction boundary electrophoresis

Guo CY, Wang HY, Liu XP, Fan LY, Zhang L, Cao CX


2013, 34(9-10):1343-51.


A simple chip free-flow electrophoresis for monosaccharide sensing via supermolecule interaction of boronic acid functionalized quencher and fluorescent dye

Yin XY, Dong JY, Wang HY, Li S, Fan LY, Cao CX


2013, 34(15):2185-92.


Global control of GacA in secondary metabolism, primary metabolism, secretion systems, and motility in the rhizobacterium Pseudomonas aeruginosa M18

Wei X, Huang XQ, Tang LL, Wu DQ, Xu YQ

J Bacteriol,

2013, 195(15):3387-400.


Characterization of the N-methyltransferase CalM involved in calcimycin biosynthesis by Streptomyces chartreusis NRRL 3882

Wu QL, Gou LX, Lin SJ, Liang JD, Yin J, Zhou XF, Bai LQ, An DR, Deng ZX, Wang ZJ


2013, 95(7):1487-93.


The role of aromatic L-amino acid decarboxylase in bacillamide C biosynthesis by Bacillus atrophaeus C89

Lei YW, Zhang FL, Chen QH, Lin SJ, Zhao YL, Li ZY

Sci Rep,

2013, 3:1753.


Engineering of cofactor regeneration enhances (2S,3S)-2,3-butanediol production from diacetyl

Wang Y, Li LX, Ma CQ, Gao C, Tao F, Xu P

Sci Rep,

2013, 3:2643.


Iron(II)-dependent dioxygenase and N-formylamide deformylase catalyze the reactions from 5-hydroxy-2-pyridone to maleamate

Yao YX, Tang HZ, Ren HX, Yu H, Wang LJ, Zhang W, Behrman EJ, Xu P

Sci Rep,

2013, 3:3235.


A novel thermophilic beta-glucosidase from caldicellulosiruptor bescii: characterization and its synergistic catalysis with other cellulases

Bai AX, Zhao XY, Jin YW, Yang GY, Feng Y

J Mol Catal B-Enzym,

2013, 85-86:248-56.


Phylogenetically diverse denitrifying and ammonia-oxidizing bacteria in corals Alcyonium gracillimum and Tubastraea coccinea

Yang S, Sun W, Zhang FL, Li ZY

Mar Biotechnol,

2013, 15(5):540-51.


Elicitation of ginsenoside biosynthesis in cell cultures of Panax ginseng by vanadate

Huang C, Zhong JJ

Process Biochem,

2013, 48(8):1227-34.


Enhanced production of (+)-terrein by Aspergillus terreus strain PF26 with epigenetic modifier suberoylanilide hydroxamic acid

Xiao L, Yin Y, Sun W, Zhang FL, Li ZY

Process Biochem,

2013, 48(11):1635-39.


Virtual screening for alpha7 nicotinic acetylcholine receptor for treatment of Alzheimer's disease

Chen SG, Gu RX, Dai H, Wei DQ

J Mol Graph,

2013, 39:98-107.


Biosynthesis and pathway engineering of antifungal polyene macrolides in actinomycetes

Kong DK, Lee MJ, Lin SJ, Kim ES

J Ind Microbiol Biotechnol,

2013, 40(6):529-43.


OxyR, an important oxidative stress regulator to phenazines production and hydrogen peroxide resistance in Pseudomonas chlororaphis GP72

Xie K, Peng HS, Hu HB, Wang W, Zhang XH

Microbiol Res,

2013, 168(10):646-53.


Quantitative investigation on the stacking of metal ions induced by another metal ion based on moving substitution boundary electrophoresis

Lou J, Liu Q, Wang HY, Fan LY, Zhang SS, Liang H, Cao CX

Anal Methods

2013, 5(22):6345-51.


Improved heterologous erythromycin A production through expression plasmid re-design

Jiang M, Fang L, Pfeifer BA

Biotechnol Prog

2013, 29(4):862-69.


Molecular dynamics simulations of amyloid fibrils: an in silico approach

Ye W, Wang W, Jiang C, Yu QF, Chen HF

Acta Biochim Biophys Sin,

2013, 45(6):503-08.


Exploring the ligand-protein networks in traditional Chinese medicine: current databases, methods, and applications

Zhao MZ, Zhou Q, Ma WH, Wei DQ

Evid-based Complement Altern Med,



Expression, purification and biochemical characterization of Methanocaldococcus jannaschii DNA ligase

Wang Y, Xie JJ, Han Z, Liu JH, Liu XP

Protein Expr Purif,

2013, 87(2):79-86.


Insight into the binding mode between HIV-1 integrase and pyrimidone analogue inhibitors with MD simulation and 3D-QSAR

Ma SY, Ye W, Ji DJ, Chen HF

Med Chem,

2013, 9(3):420-33.


Discovering the roles of subsurface microorganisms: Progress and future of deep biosphere investigation

Wang FP, Lu SL, Orcutt BN, Xie W, Chen Y, Xiao X, Edwards KJ

Chin Sci Bull,

2013, 58(4-5):456-67.


Evidence from O-18 feeding studies for hydroxyl group donor in the reaction catalyzed by cytidylate hydroxymethylase MilA

Chen C, Gao TL, Zhao G, Deng ZX, Hu SC, Xu HH, He XY

Chin Sci Bull,

2013, 58(8):864-68.


Enhanced production of (+)-terrein in fed-batch cultivation of Aspergillus terreus strain PF26 with sodium citrate

Yin Y, Xu BL, Li ZY, Zhang BH

World J Microbiol Biotechnol,

2013, 29(3):441-46.


Applications of rare event dynamics on the free energy calculations for membrane protein systems

Wang YK, Wei DQ, Gu RX, Fan HM, Ulmschneider J

Can J Chem-Rev Can Chim,

2013, 91(9):769-74.


The resolution of aglinin A epimers and their NMR assignments

Feng TX, Qu SJ, Tan JJ, Jiang K, Tan CH, Lin SJ

J Asian Nat Prod Res,

2013, 15(1):89-93.


High-performance liquid chromatography analysis of Lomofungin in Streptomyces lomondensis

Li S, Ye QM, Wang W, Hu HB, Zhang XH

J Liq Chromatogr Relat Technol,

2013, 36(15):2059-68.


Genome sequences of two morphologically distinct and thermophilic Bacillus coagulans strains, H-1 and XZL9

Xu K, Su F, Tao F, Li C, Ni J, Xu P

Genome announcements,

2013, 1(3).


Genome sequence of Clostridium diolis strain DSM15410, a promising natural producer of 1, 3-propanediol

Wang Y, Tao F, Tang H, Xu P

Genome announcements,

2013, 1(4):e00542-13.


Genome sequence of Klebsiella pneumoniae strain ATCC 25955, an oxygen-insensitive producer of 1, 3-propanediol

Wang Y, Tao F, Li C, Li L, Xu P

Genome announcements,

2013, 1(4):e00587-13.


Metagenome reveals potential microbial degradation of hydrocarbon coupled with sulfate reduction in an oil-immersed chimney from Guaymas Basin

He Y, Xiao X, Wang F

Frontiers in microbiology,

2013, 4:148.


Direct biodiesel production from wet microalgae biomass of Chlorella pyrenoidosa through in situ transesterification

Cao HC, Zhang ZL, Wu XW, Miao XL

Biomed Res Int,

2013, 930686.


Asm8, a specific LAL-type activator of 3-amino-5-hydroxybenzoate biosynthesis in ansamitocin production

Pan WQ, Kang QJ, Wang L, Bai LQ, Deng ZX

Sci China-Life, Sci

2013, 56(7):601-08.


Biosynthesis of 3,5-AHBA-derived natural products

Kang Q, Shen Y, Bai L

Nat Prod Rep,

2012, 29(2):243-263


Toward steadfast growth of antibiotic research in China: From natural products to engineered biosynthesis

Kang Q, Bai L, Deng Z

Biotechnol Adv,

2012, 30(6):1228-1241


Production of biomass and useful compounds from adventitious roots of high-value added medicinal plants using bioreactor.

Baque MA, Moh SH, Lee EJ, Zhong JJ, Paek KY

Biotechnol Adv,

2012, 30(6):1255-67


Impacts of calcium signal transduction on the fermentation production of antitumor ganoderic acids by medicinal mushroom Ganoderma lucidum.

Xu YN, Zhong JJ

Biotechnol Adv,

2012, 30(6):1301-8


Structural basis for the recognition of Asef by adenomatous polyposis coli.

Zhang Z, Chen L, Gao L, Lin K*, Zhu L, Lu Y, Shi X, Gao Y, Zhou J, Xu P, Zhang J, Wu G

Cell Res,

2012, 22(2):372-86


Structural insights into DndE from Escherichia coli B7A involved in DNA phosphorothioation modification.

Hu W, Wang C, Liang J, Zhang T, Hu Z, Wang Z, Lan W, Li F, Wu H, Ding J, Wu G, Deng Z, Cao C

Cell Res,

2012, 22(7):1203-6


ICEberg: a web-based resource for integrative and conjugative elements found in Bacteria.

Bi D, Xu Z, Harrison EM, Tai C, Wei Y, He X, Jia S, Deng Z, Rajakumar K, Ou HY

Nucleic Acids Res,

2012, 40 (D1):D621-6


Phosphorothioate DNA as an antioxidant in bacteria.

Xie X, Liang J, Pu T, Xu F, Yao F, Yang Y, Zhao YL, You D, Zhou X, Deng Z, Wang Z

Nucleic Acids Res,

2012, 40(18):9115-24


Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers.

Wang T, Cai G, Qiu Y, Fei N, Zhang M, Pang X, Jia W, Cai S, Zhao L


2012, 6(2):320-9


Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations.

Zhang C, Zhang M, Pang X, Zhao Y, Wang L, Zhao L


2012, 6(10):1848-57


Elucidation of piericidin A1 biosynthetic locus revealed a thioesterase-dependent mechanism of α-pyridone ring formation.

Liu Q, Yao F, Chooi Y, Kang Q, Xu W, Li Y, Shao Y, Shi Y, Deng Z, Tang Y, You D

Chem Biol,

2012, 19(2):243-53


Unveiling the post-PKS redox tailoring steps in biosynthesis of the type II polyketide antitumor antibiotic xantholipin.

Zhang W, Wang L, Kong L, Wang T, Chu Y, Deng Z, You D

Chem Biol,

2012, 19(3):422-32


Engineering of an industrial polyoxin producer for the rational production of hybrid peptidyl nucleoside antibiotics.

Zhai L, Lin S, Qu D, Hong X, Bai L, Chen W, Deng Z

Metab Eng,

2012, 14(4):388-93


Prediction and functional analysis of single nucleotide polymorphisms.

Li L, Chen Q, Wei DQ

Curr Drug Metab,

2012, 13(7):1012-23


RNase HIII from Chlamydophila pneumoniae can efficiently cleave double-stranded DNA carrying a chimeric ribonucleotide in the presence of manganese.

Lu Z, Liang R, Liu X, Hou J, Liu J

Mol Microbiol,

2012, 83(5):1080-93


Appendant structure plays an important role in amyloidogenic cystatin dimerization prior to domain swapping

Yu Y, Liu X, He J, Zhang M, Li H, Wei D, Song Y

J Biomol Struct Dyn,

2012, 287(35):29568-78


Performance and bacterial compositions of aged refuse reactors treating mature landfill leachate.

Xie B, Xiong S, Liang S, Hu C, Zhang X, Lu J

Bioresour Technol,

2012, 103(1):71-7


Efficient conversion of 1,2-butanediol to (R)-2-hydroxybutyric acid using whole cells of Gluconobacter oxydans

Gao C, Zhang W, Huang Y, Ma C, Xu P

Bioresour Technol,

2012, 115:75-8


Biocatalytic production of (2S,3S)-2,3-butanediol from diacetyl using whole cells of engineered Escherichia coli

Li L, Wang Y, Zhang L, Ma C, Wang A, Tao F, Xu P

Bioresour Technol,

2012, 115:111-116


Alumina nanoparticles-induced effects on wastewater nitrogen and phosphorus removal after short-term and long-term exposure.

Chen Y, Su Y, Zheng X, Chen H, Yang H

Water Res,

2012, 46(14):4379-86


Crystal structure of hyperthermophilic endo-β-1, 4-glucanase: implications for catalytic mechanism and thermostability.

Zheng B, Yang W, Zhao X, Wang Y, Lou Z, Rao Z, Feng Y

J Biol Chem,

2012, 287(11):8336-46


Chimeric cellulase matrix for investigating intramolecular synergism between non-hydrolytic disruptive functions of carbohydrate-binding modules and catalytic hydrolysis.

Wang Y, Tang R, Tao J, Wang X, Zheng B, Feng Y

J Biol Chem,

2012, 287(35):29568-78


Autoinhibitory mechanism for the mutation-induced impaired FGF9 signaling.

Wang Y, Wu XL, Wei DQ, Li YX, Wang JF

J Chem Info Modeling,

2012, 30(1):102-12


Deletion of TnAbaR23 results in both expected and unexpected antibiogram changes in a multi-drug resistant Acinetobacter baumannii strain

Kochar M, Crosatti M, Harrison EM, Rieck B, Chan J, Constantinidou C, Pallen M, Ou HY, Rajakumar K

Antimicrob Agents Ch,

2012, 56(4):1845-1853


Recent progress on bioinformatics, functional genomics, and metabolomics research of cytochrome P450 and its impact on drug discovery.

Zhang T, Zhao M, Pang Y, Zhang W, Angela Liu L, Wei DQ

Curr Top Med Chem,

2012, 12(12):1346-55


Structural and functional analysis of validoxylamine A 7’-phosphate synthase ValL involved in validamycin A biosynthesis.

Zheng L, Zhou X, Zhang H, Ji X, Li L, Huang L, Bai L, Zhang H

PLoS One,

2012, 7(2):e32033


Insight into the stability of cross-beta amyloid fibril from VEALYL short peptide with molecular dynamics simulation

Ye W, Chen Y, Wang W, Yu Q, Li Y, Zhang J, Chen HF

PLoS One,

2012, 7(5):e36382


NAD-independent l-lactate dehydrogenase is required for l-lactate utilization in Pseudomonas stutzeri SDM

Gao C, Jiang T, Dou P, Ma C, Li L, Kong J, Xu P

PLoS One,

2012, 7(5):e36519


Crystal structure of the cysteine desulfurase DndA from Streptomyces lividans which is involved in DNA phosphorothioation.

Chen F, Zhang Z, Lin K*, Qian T, Zhang Y, You D, He X, Wang Z, Liang J, Deng Z, Wu G

PLoS One,

2012, 7(5):e36635


Carotenoids play a positive role in the degradation of heterocycles by Sphingobium yanoikuyae

Liu X, Gai Z, Tao F, Tang H, Xu P

PLoS One,

2012, 7(6):e39522


Transcriptional activation of pyoluteorin operon mediated by the LysR-type regulator PltR bound at a 22 bp lys box in Pseudomonas aeruginosa M18.

Li S, Huang X, Wang G, Xu Y

PLoS One,

2012, 7(6):e39538


Volatile organic compounds from a Tuber melanosporum fermentation system.

Li YY, Wang G, Li HM, Zhong JJTang YJ

Food Chem,

2012, 135(4):2628-37


Involvement of Ser94 in RNase HIII from Chlamydophila pneumoniae in the recognition of a single ribonucleotide misincorporated into double-stranded DNA.

Lu Z, Hou J, Wang Y, Liu J

Biochim Biophys Acta.,



Rationally re-designed mutation of NAD-independent l-lactate dehydrogenase: high optical resolution of racemic mandelic acid by the engineered Escherichia coli

Jiang T, Gao C, Dou P, Ma C, Kong J, Xu P

Microb Cell Fact,

2012, 23;11:151


A thermostable recombinant transaldolase with high activity over a broad pH range.

Huang SY, Zhang YH, Zhong JJ

Appl Microbiol Biotechnol,

2012, 93(6):2403-102012, 93(6):2403-10


Perstraction of intracellular pigments by submerged cultivation of Monascus in nonionic surfactant micelle aqueous solution.

Hu Z, Zhang X, Wu Z, Qi H, Wang Z

Appl Microbiol Biotechnol,

2012, 94(1):81-9


Structural analysis and biosynthetic engineering of a solubility-improved and less-hemolytic nystatin-like polyene in Pseudonocardia autotrophica.

Lee MJ, Kong D, Han K, Sherman DH, Bai L, Deng Z, Lin S, Kim ES

Appl Microbiol Biotechnol,

2012, 95(1):157-68


Comparative analysis of temperature-dependent transcriptome of Pseudomonas aeruginosa strains from rhizosphere and human habitats.

Wu DQ, Li Y, Xu Y.

Appl Microbiol Biotechnol,

2012, 96(4):1007-19. 


Bacterial and archaeal symbionts in the South China Sea sponge Phakellia fusca: community structure, relative abundance, and ammonia-oxidizing populations.

Han M, Liu F, Zhang F, Li Z, Lin H

Mar Biotechnol,

2012, 14(6):701-13


Enhancing separation of histidine from amino acids via free-flow affinity electrophoresis with gravity-induced uniform hydrodynamic flow.