ABOUT SKLMM
The State Key Laboratory of Microbial Metabolism（SKLMM）was approved by Ministry of Science and Technology of the People’s Republic of China in 2011. SKLMM takes lead in researches on metabolic science and in diverse frontier areas of microbial metabolism，with a core interest to support China’s strategic goal for sustainable development. SKLMM focuses on intensive and extensive investigation into mechanisms of microbial anabolism and catabolism, for unveiling the physiological function，regulatory networks，and their complex interactions or connections with the environments. SKLMM aims to pave solid ways for optimizing and reprogramming metabolic pathways to maximize the metabolic potential of microorganisms, and therefore promoting the fundamental and technological innovations. The laboratory team is led by the director Prof. Zixin Deng，with a total of 52 principal investigators (PI). In the past five years, they have been granted more than ￥300 million research funds. SKLMM has pioneered in research fields such as DNA sulfur modification, microbial drug biosynthesis, catabolism of refractory toxic pollutants, intestinal flora and metabolic diseases, circulation of deep ocean microbiology and elements, etc. A great number of researches were published in top journals including Science，Nat Microbiol，PNAS, etc. The number of invention patents reached more than 100. SKLMM has led a rapid development in scientific research and has received extensive attention in the ...
HIGHLIGHTS
SJTU SUCCEEDS IN DEVELOPING NOVEL & ORTHOGONAL TECHNOLOGIES
Recently, the research team led byYou Delin, an Associate Professor of State Key Laboratory of Microbial Metabolism,School of Life Sciences and Biotechnology, SJTU, succeeded in developing novel and orthogonal technologies to map phosphorothioate (PT) modifications of DNA. Their latest discovery was illustrated in paperGenomic mapping of phosphorothioates reveals partial modification of short consensus sequences,published online on JournalNature Communications.
You Delin's research team, supervised by professorDeng Zixin, discovered that it is thedndgene products that incorporate sulphur into the DNA backbone as a PT in a sequence- and stereo-specific manner. So far, many scientists have concentrated on this subject and thus formed a new research field. You's discovery is of great significance as i...
NOVEL PHOSPHOROTHIOATE-BASED RESTRICTION SYSTEM REVEALED BY
Recently, Prof. You Delin’s research team published a research paperPathological phenotypes and in vivo DNA cleavage by unrestrained activity of a phosphorothioate-based restriction system in SalmonellaonMolecular Microbiologyin the field of phosphorothioate modification of the DNA backbone. This work is coorperated with Prof. Peter C. Dedon’s team from MIT.
The research team found that the presence of restriction genes in a PT-deficient mutant resulted in several pathological phenotypes rather than lethal, which is not the same with the traditional ones.
The study not only expands our understandings on the physiological significance of phosphorothioate modification of the DNA, but also reveal that this special R-M system is not as same as the traditional ones. These findings will broaden the understanding of the diversity of genome self-defence.
RECENT PUBLICATIONS
Recently international famous journal The Journal of Biological Chemistry published an important progress in enhanced enzyme kinetic stability worked by Yan Feng group, state key lab of microbial metabolism, school of life sciences and biotechnology, SJTU.
In the study of the paper Enhanced Enzyme Kinetic Stability by Increasing Rigidity within the Active Site , it indicates that enhancing the rigidity of the flexible segment within the active site may provide an efficient method for improving enzyme kinetic stability, which can provide insight into how to design more efficient and thermostable biocatalysts.
The research is supported by 973(2012CB721003、2011CBA00800), NSFC (31370106) and 863 (2013AA102801).
Reprinted from the website of School Of Life Sciences And Biotechnology. Written by lifeadmin. Reprinted from the website of School Of Life Sciences And Biotechnology. Written by lifeadmin. Reprinted from the website of School Of Life Sciences And Biotechnology. Written by lifeadmin. Reprinted from the website of School Of Life Sciences And Biotechnology. Written by lifeadmin. Reprinted from the website of School Of Life Sciences And Biotechnology. Written by lifeadmin. Reprinted from the website of School Of Life Sciences And Biotechnology. Written by lifeadmin.