汤志军
Zhijun Tang
长聘教轨副教授
博士生导师
研究重点：
天然产物生物合成、生物催化
汤志军，博士，上海交通大学生命科学技术学院长聘教轨副教授。主要从事微生物源天然产物的生物合成和生物催化研究。围绕活性显著的聚酮和聚肽天然产物，系统开展生物合成途径和新颖酶学机制的研究，以生物合成规律为指导，进行生物催化、化学-酶催化方法开发，实现复杂天然产物的高效合成和多样性创制。迄今，在Nature Chemistry、Nature Communication、Accounts of Chemistry Research、JACS、Angew等期刊发表论文发表SCI论文20余篇，申请多项发明专利。主持包括国家自然科学基金青年项目B类、C类、面上、上海市“启明星”等多个国家和省部级项目。
教育经历
Educational experience
2014.09-2019.07 中国科学院上海有机化学研究所，化学生物学专业，博士，导师：刘文 研究员
2010.09-2014.07 四川大学，化学学院，本科
工作经历
Work experience
2025.09-至今，上海交通大学生命科学技术学院，长聘教轨副教授
2023.09-2025.08 中国科学院上海有机化学研究所，副研究员
2022.11-2023.08 中国科学院上海有机化学研究所，助理研究员
2019.08-2022.10 中国科学院上海有机化学研究所，博士后，合作导师：刘文 研究员
荣誉获奖
Honours and Awards
上海市青年科技启明星（2024）
代表性论文
Representative works
- Tang, Z. #; Pang, B.#; Liu, C.#(Co-first); Guo, S.; Qu, X & Liu, W., Formation and Loading of a (2S)-2-ethyl-malonamyl-ACP Starter Unit in the Assembly Line of Polyketide-Nonribosomal Peptide Hybrid Sanglifehrin A. Angewandte Chemie International Edition 2023, 62, e202217090.
- Tang, Z. #; Tang, H. #; Wang, W. #(Co-first); Xue, Y.; Chen, D.; Tang, W. & Liu, W., Biosynthesis of a New Fusaoctaxin Virulence Factor in Fusarium graminearum Relies on a Distinct Path to Form a Guanidinoacetyl Starter Unit Priming Nonribosomal Octapeptidyl Assembly, Journal of the American Chemical Society, 2021. 143, 19719−19730.
- Song, H.#; Zhang, Z.#; Cao, C.*; Tang, Z.* (corresponding author), Gui, J.* & Liu, W.*, Biocatalytic Steroidal 9α-Hydroxylation and Fragmentation Enable a Concise Chemoenzymatic Synthesis of 9,10-Secosteroids. Angewandte Chemie International Edition 2024, e202319624.
- Guo, S.; Sang, Y.; Zheng, C.; Xue, X.; Tang, Z.* (corresponding author) & Liu, W.*, Enzymatic α-Ketothioester Decarbonylation Occurs in the Assembly Line of Barbamide for Skeleton Editing. Journal of the American Chemical Society, 2023, 45, 9, 5017–5028.
- Pang, B. #; Liao, R. #; Tang, Z. #(Co-first); Guo, S.; Wu, Z. & Liu, W., Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2'-bipyridine formation. Nature Communication, 2021, 12, 3124.
- Wang, H. #; Zou, Y. #; Li, M. #; Tang, Z. #(Co-first); Wang, J.; Tian, Z.; Strassner, N.; Yang, Q.; Zheng, Q.; Guo, Y.; Liu, W. *; Pan, L.* & Houk, K. N.*, A Cyclase that Catalyses Competing 2+2 and 4+2 Cycloadditions. Nature Chemistry, 2023, 15, 177–184.
- Zhang, D.#; Tang, Z.# (Co-first) & Liu, W., Biosynthesis of Lincosamide Antibiotics: Reactions Associated with Degradation and Detoxification Pathways Play a Constructive Role, Accounts of Chemical Research, 2018, 51, 1496.
- Chen, M.; Pang, B.; Zhao, Q.*; Tang, Z.* (corresponding author) & Liu, W.*, Investigation of 2,2’-Bipyridine Biosynthesis Reveals a Common Two-Component System for Aldehydes Production by Carboxylate Reduction. Organic Letter, 2022, 24, 897−902.
- Ding, W.#; Zhou, M.#; Li, H.; Li, M.; Qiu, Y.; Yin, Y.; Pan, L.; Du, Y.*; Zhang, X.*; Tang, Z.* (corresponding author) & Liu, W*, Biocatalytic Fluoroalkylation Using Fluorinated S-adenosyl-L-methionine Cofactors. Organic Letter, 2023, 25, 5650−5655.
- Tang, Z., Wang, H, & Liu, W., Enzyme-Associated Pericyclic Reactions, Chapter in “Comprehensive Natural Products III”, Elsevier, 2020.
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