何亚文
Ya-Wen He
长聘教授
博士生导师
研究重点：
微生物群体感应与合成生物学
2006年获新加坡国立大学博士学位，先后在新加坡分子农业生物学院、分子与细胞生物研究院工作。2010年6月加入上海交通大学生命科学与技术学院，担任微生物群体感应与合成生物学研究室主任、微生物代谢国家重点实验室和代谢与发育国际合作联合实验室独立PI、上海交通大学-上海农乐生物农药与生物肥料联合研发中心主任、上海交通大学药食同源产品开发创新团队首席。目前已经发表100多篇研究论文，出版5本学术专著，拥有6项发明专利。实验室研究方向包括：（1）植物病原黄单胞菌群体感应以及黄单胞菌-宿主互作系统生物学；（2）生物农药、黄原胶与生物材料合成生物学；（3）药食同源中药材野生抚育、仿野生栽培与产品开发创新。
教育经历
Educational experience
2001.07-2006.10 新加坡国立大学, 博士
1997.08–1999.08新加坡国立大学, 硕士
1992.09-1995.07 中科院华南植物研究所, 硕士
1988.09–1992.07 华中师范大学, 学士
工作经历
Work experience
2010.06-至今 上海交大生命科学技术学院 特别研究员，教授，长聘教授
2006.10-2010.05 新加坡分子与细胞生物学研究院 研究员
2001.07-2006.09 新加坡分子与细胞生物学研究院 初级研究员
1999.12–2001.06新加坡分子农业生物学院 助理研究主任
1995.08-1997.07 中科院华南植物研究所, 助理研究员
荣誉获奖
Honours and Awards
代表性论文
Representative works
1. Hu WD, Chen B, Zheng Z, Poplawsky AR, He Ya-Wen. The structural diversity of xanthomonadin aryl polyenes and functional analysis of the genes required for their synthesis by Xanthomonas phytopathogens. Phytopathology Research. 2025, 7: 25.
2. Song K, Cui Y, Li SN, Li L, Zhou L, Tian DL, Gu YC, He Ya-Wen. Hydroxycinnamic Acids Activate RpfB-Dependent Quorum Sensing Signal Turnover in Phytopathogen Xanthomonas campestris. J Agric Food Chem. 2025 Feb 19;73(7):3990-4000.
3. Song K, Li RF, Cui Ying, Chen Bo, Zhou Lian, Han WY, Jiang BL#, and He Ya-Wen#. The phytopathogen Xanthomonas campestris senses and effluxes salicylic acid via a sensor HepR and an RND family efflux pump to promote virulence in host plants. mLife. 2024 Sep 16;3(3):430-444.
4. He Ya-Wen*,#, Jin Z-J*, Cui Y, Song K, Chen B, Zhou L. RsaL is a self-regulatory switch that controls alternative biosynthesis of two AHL-type quorum sensing signals in Pseudomonas aeruginosa PA1201. mLife. 2024; 3: 74–86.
5. He Ya-Wen*,#, Deng Y*, Miao Y*, Chatterjee S, Tran TM, Tian J, Lindow S. DSF-family quorum sensing signal-mediated intraspecies, interspecies, and inter-kingdom communication. Trends in Microbiology, 2023 Jan;31(1):36-50.
6. Cui Y, Song K, Jin ZJ, Lee LH, Thawai C, He Ya-Wen. Fructose promotes pyoluteorin biosynthesis via the CbrAB-CrcZ-Hfq/Crc pathway in the biocontrol strain Pseudomonas PA1201. Synthetic and Systemic Biotechnology. 2023 Sep 21;8(4):618-628.
7. Chen B, Li RF, Zhou L, Song K, Poplawsky AR, He Ya-Wen*. The phytopathogen Xanthomonas campestris scavenges hydroxycinnamic acids in planta via the hca cluster to increase virulence on its host plant. Phytopathology Research,2022, 4：12.
8. Song K, Chen B, Cui Y, Zhou L, Chan KG, Zhang HY, He Ya-Wen. The Plant Defense Signal Salicylic Acid Activates the RpfB-Dependent Quorum Sensing Signal Turnover via Altering the Culture and Cytoplasmic pH in the Phytopathogen Xanthomonas campestris. mBio. 2022 13(2): e0364421.
9. Fang YL, Cui Y, Zhou L, Thawai C, Naqvi TA, Zhang HY, He Ya-Wen. H-NS family protein MvaU downregulates phenazine-1-carboxylic acid (PCA) biosynthesis via binding to an AT-rich region within the promoter of the phz2 gene cluster in the rhizobacterium Pseudomonas strain PA1201. Synthetic and Systemic Biotechnology. 2021, 6(4): 262-271.
10. Chen B, Li RF, Zhou L, Qiu JH, Song K, Tang JL, He Ya-Wen. The phytopathogen Xanthomonas campestris utilizes the divergently transcribed pobA/pobR locus for 4-hydroxybenzoic acid recognition and degradation to promote virulence. Molecular Microbiology, 2020 Nov;114(5):870-886.
11. Jin ZJ, Zhou L, Sun S, Cui Y, Song K, Zhang X, He Ya-Wen. Identification of a Strong Quorum Sensing- and Thermo-Regulated Promoter for the Biosynthesis of a New Metabolite Pesticide Phenazine-1-carboxamide in Pseudomonas strain PA1201. ACS Synthetic Biology. 2020 Jul 17;9(7):1802-1812.
12. He Ya-Wen#,*, Cao XQ, Poplawsky AR#. Chemical structure, biological roles, biosynthesis and regulation of the yellow xanthomonadin pigments in the phytopathogen Xanthomonas. Molecular Plant Microbe Interactions. 2020, 33(5):705-714.
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