黄显清
Xianqing Huang
副教授
博士生导师
研究重点：
假单胞菌抗生素合成等次级代谢的分子调控与代谢工程
黄显清 博士，副教授。主要从事假单胞菌抗生素合成等次级代谢的分子调控、代谢工程及应用研究。作为负责人主持完成科技部863课题、国家自然科学基金（3项）、科技部重大研发计划子课题、上海自然基金等多项课题；作为骨干成员参与科技部973课题、科技部863重点项目等多项课题。以第一或通讯作者在Mol Microbiol、J Bacteriol、Appl Environ Microbiol 等国际微生物主流刊物上发表20多篇研究论文。参与完成的“微生物源农药申嗪霉素(M18)的研制及应用”项目获2007年度上海市科技进步一等奖 (第六完成人, 6/15)、2011年度教育部科技进步奖推广类二等奖(第十完成人, 10/15)。
教育经历
Educational experience
2005.04 上海交通大学生命科学技术学院，生物化学与分子生物学专业 理学博士
工作经历
Work experience
2007.12-至今 上海交通大学，生命科学技术学院生物工程系，副教授
2005.04-2007.12 上海交通大学，生命科学技术学院生物工程系，讲师
荣誉获奖
Honours and Awards
代表性论文
Representative works
[1] Zheng Wang, Xianqing Huang*, Yujie Liu, Guohuan Yang, Yang Liu, Xuehong Zhang. GacS/GacA activates pyoluteorin biosynthesis through Gac/Rsm-RsmE cascade and RsmA/RsmE-driven feedback loop in Pseudomonas protegens H78. Molecular Microbiology 2017, 105(6):968-985.
[2] Zheng Wang, Xianqing Huang*, Malik Jan, Deyu Kong, Wei Wang, Xuehong Zhang*. Lon protease downregulates phenazine-1-carboxamide biosynthesis by degrading the quorum sensing signal synthase PhzI and exhibits negative feedback regulation of Lon itself in Pseudomonas chlororaphis HT66. Molecular Microbiology 2021,116(2):690-706.
[3] Yuyuan Cai, Peng Peng Huang, Vittorio Venturi, Runyao Xiong, Zheng Wang, Wei Wang, Xianqing Huang*, Hongbo Hu, Xuehong Zhang*. Global Gac/Rsm regulatory system activates the biosynthesis of mupirocin by controlling the MupR/I quorum sensing system in Pseudomonas sp. NCIMB 10586. Applied and Environmental Microbiology 2025, 91(2), e01896-24.
[4] Chenxi Nie1, Xianqing Huang1, *, Tao Xiang, Zheng Wang, Xuehong Zhang. Discovery and characterization of the PpqI/R quorum sensing system activated by GacS/A and Hfq in Pseudomonas protegens H78. Microbiological Research 2024, 287: 127868
[5] Zheng Wang, Xianqing Huang*, Chenxi Nie, Tao Xiang, Xuehong Zhang*. The Lon protease negatively regulates pyoluteorin biosynthesis through the Gac/Rsm-RsmE cascade and directly degrades the transcriptional activator PltR in Pseudomonas protegens H78. Environmental Microbiology Reports 2022,14(4), 506–519.
[6] Zheng Wang, Xianqing Huang*, Malik Jan, Deyu Kong, Jingwen Pan, Xuehong Zhang*. The global regulator Hfq exhibits far more extensive and intensive regulation than Crc in Pseudomonas protegens H78. Molecular Plant Pathology 2021, 22(8):921-938
[7] Guohao Wang1, Xianqing Huang1, *, Sainan Li, Jiaofang Huang, Xue Wei, Yaqian Li, and Yuquan Xu*. The RNA chaperone Hfq regulates antibiotic biosynthesis in the rhizobacterium Pseudomonas aeruginosa M18. Journal of Bacteriology 2012, 194: 2443-2457.
[8] Xue Wei 1, Xianqing Huang 1, *, Lulu Tang, Daqiang Wu, Yuquan Xu*. Global control of GacA in secondary metabolism, primary metabolism, secretion systems, and motility in the rhizobacterium Pseudomonas aeruginosa M18. Journal of Bacteriology 2013, 195(15): 3387-3400.
（1并列第一作者，*通讯作者)
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