孔令新
Lingxin Kong
副研究员
硕士生导师
研究重点：
微生物来源天然产物的生物合成
专注于微生物来源的天然产物的发现与生物合成机制，综合运用分子遗传学、生物化学、分子酶学及结构生物学等方法，系统开展活性天然产物挖掘、生物合成途径解析、分子调控机制阐明、关键活性基团合成生物学改造等研究。聚焦于以黄脂菌素为代表的细菌来源多环氧杂蒽酮类化合物，深入研究其关键活性基团，成功发现新型氧化酶催化脱甲氧基化反应，并阐明其生物合成的分子调控机制。该工作深化了对此类化合物生物合成规律的理解，为推进其高产改造与开发应用奠定了重要理论基础。目前主持和参加国家自然基金青年基金和面上基金、科技部重点研发计划项目共4项，博士后面上及校级理科项目各1 项。以第一或通讯作者在天然产物重要期刊Natural Product Reports、Cell Chemical Biology、Applied and Environmental Microbiology、Synthetic and Systems Biotechnology等发表论文14篇。
教育经历
Educational experience
2009.09-2016.06 上海交通大学 理学博士
2005.09-2009.09 德州学院 理学学士
工作经历
Work experience
2022.12-至今 上海交通大学，生命科学技术学院 副研究员
2020.11-2022.12 上海交通大学生，命科学技术学院 助理研究员
2017.01-2020.10 上海交通大学，药学院博士后科研流动站 科研助理
荣誉获奖
Honours and Awards
代表性论文
Representative works
1. Qiao Y, Wang J, Zhang D, Zheng X, Lin B, Huang Y, Liao Y, Deng Z, Kong L*, You D*. Biosynthesis of the benzylpyrrolidine precursor in anisomycin by a unique ThDP-dependent enzyme, Synthetic and Systems Biotechnology, 2025, 10(1): 76-85.
2. Lin B, Zhang D, Wang J, Qiao Y, Wang J, Deng Z, Kong L*, You D*. O-methyltransferase CbzMT catalyzes iterative 3,4-dimethylations for carbazomycin biosynthesis. Engineering Microbiology, 2024, 4(2): 100150
3. Kong L, Deng Z, You D*. Chemistry and biosynthesis of bacterial polycyclic xanthone natural products. Nat Prod Rep. 2022, 39(11):2057-2095.
4. Zhang D, Wang J, Qiao Y, Lin B, Deng Z, Kong L*, You D*. Genome mining and metabolic profiling reveal cytotoxic cyclodipeptides in Streptomyces hygrospinosus var. Beijingensis. Antibiotics. 2022, 11(11):1463.
5 Wang Q, Kong L , Zheng X, Shen J , Wang J , Zhang D , Qiao Y , Wang J , Deng Z, You D*. Acyltransferase AniI, a tailoring enzyme with broad substrate tolerance for high-level production of anisomycin. Applied and Environmental Microbiology 2021, 87(14).
6. Kong L, Wang Q, Deng Z, You D*. Flavin adenine dinucleotide-dependent halogenase XanH and engineering of multifunctional fusion halogenases. Applied and Environmental Microbiology 2020, 86(18).
7. Kong L, Wang Q, Yang W, Shen J, Li Y, Zheng X, Wang L, Chu Y, Deng Z, Chooi Y-H*, You D*. Three recently diverging duplicated methyltransferases exhibit substrate-dependent regioselectivity essential for xantholipin biosynthesis. ACS Chemical Biology 2020, 15(8): 2107-2115.
8 Li Y, Kong L, Shen J, Wang Q, Liu Q, Yang W, Deng Z, You D*. Characterization of the positive SARP family regulat or PieR for improving piericidin A1 production in Streptomyces piomogeues var. Hangzhouwanensis. Synthetic and Systems Biotechnology, 2018, 4(1):16-24.
9. Shen J, Kong L, Li Y, Zheng X, Wang Q, Yang W, Deng Z, You D*. A LuxR family transcriptional regulator AniF promotes the production of anisomycin and its derivatives in Streptomyces hygrospinosus var. beijingensis. Synthetic and Systems Biotechnology, 2019,4(1):40-48.
10. Kong L, Zhang W, Chooi Y-H, Wang L, Cao B, Deng Z, You D. A multifunctional monooxygenase XanO4 catalyzes xanthone formation in xantholipin biosynthesis via a cryptic demethoxylation. Cell Chemistry Biology, 2016; 23(4):508-516.
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