孔旭东
Xu-Dong Kong
长聘教轨副教授
博士生导师
研究重点：
噬菌体展示环肽与蛋白筛选
孔旭东，上海交通大学生命科学技术学院/张江高等研究院，长聘教轨副教授，博导。主要研究方向为基于噬菌体展示技术的环肽和蛋白药物筛选、蛋白结构解析及其功能的定向进化。近年来在Nat Chem、Nat Biomed Eng、PNAS、Angew Chem Int Ed等刊物发表多篇研究论文。获得国家重点研发计划合成生物学重点专项（2020年，2021年）、国家自然科学基金青年项目（2021年）、面上项目（2023年）、长三角科技创新共同体联合攻关专项（2025年）等项目资助。
教育经历
Educational experience
2009.09-2015.03 华东理工大学 生物化工 博士
2005.09-2009.06 华东理工大学 生物工程 学士
工作经历
Work experience
2020.08-至今 上海交通大学，生命科学技术学院/张江高等研究院，长聘教轨副教授
2015.05-2020.07 洛桑联邦理工学院（瑞士），博士后
荣誉获奖
Honours and Awards
2014年博士研究生国家奖学金
代表性论文
Representative works
1. Guo, Q.; Zeng, H.; Kong, X.D.# Phage Selection of Cyclic Peptides Inhibiting Aminoglycoside Phosphotransferases to Control Resistant Bacteria. ACS Chem. Biol. 2025, in press (doi/10.1021/acschembio.5c00366).
2. Ma, B.D.; Li, J.Y.; Xu, J.H.; Yu, T.; Kong, X.D.# ADP-ribose is a competitive inhibitor of methanol dehydrogenases from Bacillus methanolicus. J. Biol. Chem. 2025, 110599.
3. Kong, X.D.#; Zhang, M.J.; Heinis, C#. Phage Display Selection against a Mixture of Protein Targets. ACS Chem. Biol. 2025, 20, 6, 1288–1297.
4. Kong, X.D.# and Tian C., De novo discovery of bicycles. Nat. Chem. Biol. 2025, 21, 29–31.
5. Han, Y., Luo, Y., Ma, B.D., Li J.#, Xu, J.H.#, and Kong, X.D.#, Structural insights of a cis-epoxysuccinate hydrolase facilitate the development of robust biocatalysts for the production of l-(+)-tartrate. Biochem. 2024, 63, 12, 1578–1587.
6. He, R.N., Zhang, M.J., Dai B.# and Kong, X.D.#, Selection of peptide−bismuth bicycles using phage display. ACS Chem. Biol. 2024, 19, 5, 1040–1044.
7. Zhu, X.X., Zheng, W.Q., Xia, Z.W., Chen, X.R., Jin, T., Ding, X.W., Chen, F.F., Chen, Q., Xu, J.H., Kong, X.D.#, and Zheng, G.W.#, Evolutionary insights into the stereoselectivity of imine reductases based on ancestral sequence reconstruction. Nat. Commun. 2024, 15: 10330.
8. Sun, C., Ma, B.-D., Li, G., Tian, W., Yang, L., Peng, H., Lin, Z., Deng, Z., Kong, X.D.#, and Qu, X.#, Engineering the substrate specificity of a P450 dimerase enables the collective biosynthesis of heterodimeric tryptophan-containing diketopiperazines. Angew. Chem. Int. Ed. 2023, 62: e202304994.
9. Kong X.D., Moriya J., Carle V., Pojer F., Abriata L.A., Deyle K., Heinis C. De novo development of proteolytically resistant therapeutic peptides for oral administration. Nat. Biomed. Eng. 2020, 4, 560–571.
10. Kong X.D., Carle V., Díaz-Perlas C., Butler K., Heinis C. Generation of a large peptide phage display library by self-ligation of whole-plasmid PCR product. ACS Chem. Biol. 2020, 15, 2907–2915.
11. Kale S.S.*, Villequey C.*, Kong X.D.*, Zorzi A., Deyle K., Heinis C. Cyclization of peptides with two chemical bridges affords large scaffold diversities. Nat. Chem. 2018, 10, 715-723.
12. Kong, X.D., Yuan, S.G., Li, L., Chen, S., Xu, J.H. and Zhou, J. Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates. Proc. Natl. Acad. Sci. USA, 2014, 111, 15717-15722.
13. Kong, X.D., Ma, Q., Zhou, J., Zeng, B.B. and Xu, J.H. A smart library of epoxide hydrolase variants and the top hits for synthesis of (S)-beta-blocker precursors. Angew Chem. Int. Ed. 2014, 53, 6641-6644.
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