刘然
Ran Liu
副研究员
硕士生导师
闵行校区生物药学楼4号楼4B-423
l_ran@sjtu.eu.cn
研究重点: 合成生物学;代谢工程;微生物药物高效合成;微生物天然产物高通量挖掘 ;代谢互作
刘然博士主要从事微生物代谢及其与人体互作机制解析的相关研究工作。构建了集成基因组驱动的代谢解析、异源表达和无细胞表达等先进技术的微生物代谢研究平台,可解析微生物复杂的代谢途径,并高效合成相关代谢物。随后,基于该平台揭示了肠道微生物降解睾酮从而引起男性抑郁症的机制,并首次鉴定了肉芽肿性小叶性乳腺炎的病原菌及其分泌新型糖脂代谢物引起疾病的机制。以第一或通讯作者(含共同)在Cell Host & Microbe、Nature Communications、Signal Transduction and Targeted Therapy、Advanced Science等期刊上发表多篇论文,授权19项发明专利,主持国家自然科学基金等多项科研项目。
教育经历
Educational experience
2016.09-2020.06 武汉大学,药学院,生物化学与分子生物学专业,博士
2010.09-2012.06 武汉大学,药学院,微生物与生化药学专业,硕士
2006.09-2010.06 四川农业大学,生命科学与理学院,生物科学专业,本科
工作经历
Work experience
2024.04-至今 上海交通大学,生命科学技术学院,副研究员
2020.09-2024.03 中国科学院深圳先进技术研究院,合成生物学研究所,副研究员
荣誉获奖
Honours and Awards
2019年,获湖北省科技进步奖一等奖,《生物基法尼烯为前体合成维生素E的创新工艺》
代表性论文
Representative works
1. Zou Y, Wang R, Liu Z, Zou Y, Zeng S, Fang M, Chen H, Wang P, Xie C, Deng Z, Zhang F*, Liu R*, Liu T*. Development of a versatile chassis for the efficient production of diverse type II polyketides. Nat Commun. 2025,16(1), 7321.
2. Liu R, Luo Z, Dai C, Wei Y, Yan S, Kuang X, Qi K, Fu A, Li Y, Fu S, Ma Z, Dai W, Xiao X, Wu Q, Zhou H, Rao Y, Yuan J, Shi T, Deng Z*, Chen C*, Liu T*. Corynebacterium parakroppenstedtii secretes a novel glycolipid to promote the development of granulomatous lobular mastitis. Signal Transduct Target Ther. 2024, 9(1), 292.
3. Yan P#, Wang G#, Huang M#, Liu Z, Dai C, Hu B, Gu M, Deng Z, Liu R*, Wang X*, Liu T*. Combinatorial Biosynthesis Creates a Novel Aglycone Polyether with High Potency and Low Side Effects Against Bladder Cancer. Adv Sci. 2024, 11(32), e2404668.
4. Mu X, Lei R, Yan S, Liu R*, Liu T*. The LysR family transcriptional regulator ORF-L16 regulates spinosad biosynthesis in Saccharopolyspora spinosa. Synth Syst Biotechnol. 2024, 9 (4), 609-617.
5. Duan Y#, Fang F#, Mu X, Wang H, Shen Z, Deng Z, Liu T, Wang Z*, Liu R*. Exploration of Streptomyces fradiae J1-021 as a potential host for the heterologous production of spinosad. J Agric Food Chem. 2024, 72(16), 8983–8992 .
6. Li D#, Liu R#, Wang M#, Peng R#, Fu S, Fu A, Le J, Yao Q, Yuan T, Chi H, Mu X, Sun T, Liu H, Yan P, Wang S, Cheng S, Deng Z, Liu Z*, Wang G*, Li Y*, Liu T*.3β-Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males. Cell Host Microbe. 2022, 30(3),329-339.
7. Hu B#, Liu R#, Tang X#, Pan Y#, Wang M#, Tong Y#, Ye G#, Shen G#, Ying R, Fu A, Li D, Zhao W, Peng J, Guo J, Men D, Yao X, Wang Y, Zhang H, Feng Z, Yu J, Chen L, Deng Z, Lu X, Zhang YP*, Li Y*, Liu B*, Yu L*, Li Y*, Lu J*, Liu T*. The concordance between the evolutionary trend and the clinical manifestation of the two SARS-CoV-2 variants. Natl Sci Rev. 2021, 8(8), nwab073.
8. Wang M#, Fu A#, Hu B#, Tong Y#, Liu R#, Liu Z#, Gu J, Xiang B, Liu J, Jiang W, Shen G, Zhao W, Men D, Deng Z, Yu L, Wei W*, Li Y*, Liu T*. Nanopore Targeted Sequencing for the Accurate and Comprehensive Detection of SARS-CoV-2 and Other Respiratory Viruses. Small. 2021, 17(32), e2104078.
9. An Z#, Tao H#, Wang Y, Xia B, Zou Y, Fu S, Fang F, Sun X, Huang R, Xia Y, Deng Z, Liu R*, Liu T*. Increasing the heterologous production of spinosad in Streptomyces albus J1074 by regulating biosynthesis of its polyketide skeleton. Synth Syst Biotechnol. 2021, 6(4), 292-301.
10. Liu R#, Yu D#, Deng Z, Liu T*. Harnessing in vitro platforms for natural product research: in vitro driven rational engineering and mining (iDREAM). Curr Opin Biotech. 2021, 69, 1-9.
11. Liu R, Zhang Y, Zhai G, Fu S, Xia Y, Hu B, Cai X, Zhang Y, Li Y, Deng Z, Liu T*. A cell-free platform based on nisin biosynthesis for discovering novel lanthipeptides and guiding their overproduction in vivo. Adv Sci. 2020, 7(17), 2001616.
12. Liu R, Fang F, An Z, Huang R, Wang Y, Sun X, Fu S, Fu A, Deng Z, Liu T. Genomics-driven discovery of the biosynthetic gene cluster of maduramicin and its overproduction in Actinomadura sp. J1-007. J Ind Microbiol Biotech. 2020, 47(2), 275-285.
13. Liu R, Fu A, Deng Z, Li Y, Liu, T*. Promising methods for detection of novel coronavirus SARS‐CoV‐2. View, 2020, 1, e4.
14. Liu R, Deng Z, Liu T*. Streptomyces species: Ideal chassis for natural product discovery and overproduction. Metab Eng. 2018, 50,74-84.
15. Liu R, Zhu F, Lu L, Fu A, Lu J, Deng Z, Liu T*. Metabolic engineering of fatty acyl-ACP reductase-dependent pathway to improve fatty alcohol production in Escherichia coli. Metab Eng. 2014, 22, 10-21.
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