刘天罡
Tiangang Liu
特聘教授
博士生导师
研究重点：
合成生物学；代谢工程；微生物药物高效合成；微生物天然产物高通量挖掘 ；代谢互作
刘天罡教授长期从事代谢工程和合成生物学研究，致力于微生物天然产物的高效合成和高通量基因组挖掘与改造，带领科研团队针对复杂天然产物生产效率低、发现速度慢两个难题进行攻关，建立自动化微生物铸造平台，微生物代谢物检测平台，开发基于体外重建和无细胞体系的分析方法，打造了多种天然化合物高效合成的底盘细胞，并助力提升多种天然产物工业合成效率和水平。最近将高效底盘结合自动化平台用于天然产物的基因组挖掘，实现了新化合物的批量挖掘。并探索微生物与人体健康的代谢互作。作为项目负责人主持国家重点研发计划合成生物学专项项目，并以第一完成人获2018年湖北十大科技事件和2019年湖北省科技进步一等奖，作为通讯作者发表了Nature, Nature Catalysis等百篇论文。
教育经历
Educational experience
2002.09-2008.04 上海交通大学生命科学技术学院，微生物学专业，博士学位
2006.10-2007.12 美国布朗大学化学系，有机化学专业，博士生联合培养
1998.09-2002.06 山东大学生命科学学院，微生物工程专业，学士学位
工作经历
Work experience
2024.02-至今 上海交通大学生命科学技术学院，特聘教授
2010.09-2024.01 武汉大学药学院教授，博导
2008.05-2010.08 美国斯坦福大学化学系，博士后
荣誉获奖
Honours and Awards
2019 “生物基法尼烯为前体合成维生素E的创新工艺”获湖北省科学技术进步奖一等奖
2019 “维生素E合成工艺创新取得重大突破”被评为2018年湖北十大科技事件
2017 湖北省政府专项津贴
2012 湖北省楚天学者特聘教授
代表性论文
Representative works
1. Zou Y, Wang R, Liu Z, Zou Y, Zeng S, Fang M, Chen H, Wang P, Xie C, Deng Z, Zhang F*, Liu R*, Liu T*. 2025. Development of a versatile chassis for the efficient production of diverse type II polyketides. Nature Communications, 16(1), 7321.
2. Li J#, Mu X#, Dong W#, Chen Y, Kang Q, Zhao G, Hou J, Ramon Gonzalez, Bai L, Feng Y, Yang C*, Liu T*, Tan Z*. 2024. A non-carboxylative route for the efficient synthesis of central metabolite malonyl-CoA and its derived products. Nature Catalysis, 7, 361–374.
3. Liu R, Luo Z, Dai C, Wei Y, Yan S, Kuang X, Qi K, Fu A, Li Y, Fu S, Ma Z, Dai W, Xiao X, Wu Q, Zhou H, Rao Y, Yuan J, Shi T, Deng Z*, Chen C*, Liu T*. 2024. Corynebacterium parakroppenstedtii secretes a novel glycolipid to promote the development of granulomatous lobular mastitis. Signal Transduction and Targeted Therapy, 9:292.
4. Yan P#, Wang G#, Huang M#, Liu Z, Dai C, Hu B, Gu M, Deng Z, Liu R*, Wang X*, Liu T*. 2024. Combinatorial biosynthesis creates a novel aglycone polyether with high potency and low side effects against bladder cancer. Advanced Science, 11, 2404668.
5. Zhi Y#, Dai C#, Fang X, Xiao X, Lu Hui, Chen F, Chen R, Ma W, Deng Z, Lu L*, Liu T*. 2024. Gene-Directed in vitro mining uncovers the insect-repellent constituent from Mugwort (Artemisia argyi). Journal of the American Chemical Society, 146, 30883−30892.
6. Deng X#, Ye Z#, Duan J, Chen F, Zhi Y, Huang M, Huang M, Cheng W, Dou Y, Kuang Z, Huang Y, Bian G, Deng Z, Liu T*, Lu L*. 2023. Complete pathway elucidation and heterologous reconstitution of (+)-nootkatone biosynthesis from Alpinia oxyphylla. New Phytologist, 241: 779–792.
7. Huang Y#, Ye Z#, Wan X#, Yao G#, Duan J, Liu J, Yao M, Sun X, Deng Z, Shen K*, Jiang H*, Liu T*. Systematic mining and evaluation of the sesquiterpene skeletons as high energy aviation fuel molecules. Advanced Science, 202300889.
8. Sun X#, Yuan Y#, Chen Q#, Nie S, Guo J, Ou Z, Huang M, Deng Z*, Liu T*, Ma T*. 2022. Metabolic pathway assembly using docking domains from type I cis-AT polyketide synthases. Nature Communications, 13:5541.
9. Ye Z, Huang Y, Shi B, Xiang Z, Tian Z, Huang M, Wu, L, Deng Z, Shen K, Liu T*. 2022. Coupling cell growth and biochemical pathway induction in Saccharomyces cerevisiae for production of (+)-valencene and its chemical conversion to (+)- nootkatone. Metabolic Engineering, 72:107-115.
10. Tao H#, Lauterbach L#, Bian G#, Chen R#, Hou A#, Mori T#, Cheng S, Hu B, Lu L, Mu X, Adachi N, Kawasaki M, Moriya T, Senda T, Wang X, Deng Z, Abe I*, Dickschat J S*, Liu T*. 2022. Discovery of non-squalene triterpenes. Nature, 606(7913): 414-419.
11. Ye Z, Huang Y, Ma T, Xiang Z, Hu B, Kuang Z, Huang M, Lin X, Tian Z, Deng Z, Shen K, Liu T*. 2022. Revolution of vitamin E production by starting from microbial fermented farnesene to isophytol. The Innovation, 3(3): 100228.
12. Yuan Y#, Cheng S#, Bian G#, Yan P, Ma Z, Dai W, Chen R, Fu S, Huang H, Chi H, Cai Y, Deng Z, Liu T*. 2022. Efficient exploration of terpenoid biosynthetic gene clusters in filamentous fungi. Nature Catalysis, 5, 277-287.
13. Li D#, Liu R#, Wang M#, Peng R#, Fu S, Fu A, Le J, Yao Q, Yuan T, Chi H, Mu X, Sun T, Liu H, Yan P, Wang S, Cheng S, Deng Z, Liu Z*, Wang G*, Li Y*, Liu T*.2022. 3β-Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males. Cell Host & Microbe, 30:1-11
14. Chen R, Jia Q, Mu X, Hu B, Sun X, Deng Z, Chen F*, Bian G*, Liu T*. 2021. Systematic mining of fungal chimeric terpene synthases using an efficient precursor-providing yeast chassis. Proceedings of the National Academy of Sciences of the United States of America, 118: e2023247118.
15. He H#, Bian G#, Herbst-Gervasoni C#, Mori T, Shinsky S, Hou A, Mu X, Huang M, Cheng S, Deng Z, Christianson D*, Abe I*, Liu T*. 2020. Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases. Nature Communications, 11:3958.
16. Kang W#, Ma T#, Liu M, Qu J, Liu Z, Zhang H, Shi B, Fu S, Ma J, Lai L, He S, Qu J, Au S, Kang B, Lau W, Deng Z, Xia J*, Liu T*. 2019. Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux. Nature Communications, 10: 4248.
17. Ma T, Shi B, Ye Z, Li X, Liu M, Chen Y, Xia J, Jens N, Deng Z, Liu T*. 2019. Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene. Metabolic Engineering, 52: 134- 142.
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