刘昱
Yu Liu
长聘副教授
博士生导师
研究重点：
RNA前沿技术开发与修饰机制研究
北京师范大学化学专业学士，Wayne State University化学博士，National Institutes of Health博士后及助理研究员，现任上海交通大学独立课题组组长，博士生导师。专注于RNA前沿技术开发与应用研究，具体包括：RNA位点特异性标记新方法的开发；RNA及其复合物的动态修饰-结构-功能关系研究；新型RNA元件的筛选与表征；核酸药物与疫苗的理性设计与性能优化。相关研究成果以通讯/第一作者身份发表在Nature，Nature Chemistry, Nature Protocols, Nature Communications, Science Advances, PNAS, JACS 等著名期刊上。
教育经历
Educational experience
韦恩州立大学 化学 博士
北京师范大学 化学专业 学士
工作经历
Work experience
上海交通大学 独立课题组组长，博士生导师
美国国立卫生研究院 博士后及助理研究员
荣誉获奖
Honours and Awards
代表性论文
Representative works
1. Chen, D., Han, Z., Liang, X. & Liu, Y.*. Engineering a DNA polymerase for modifying large RNA at specific positions. Nat. Chem. 17, 382-392 (2025).
2. Chen, D., Li, J., Wu, Y., Hong, L. & Liu, Y.*. Structural dynamics-guided engineering of a riboswitch RNA for evolving c-di-AMP synthases. Sci. Adv. 11, eadt8165 (2025).
3. Liang, X., Chen, D., Su, A. & Liu, Y.*. Divergent molecular assembly and catalytic mechanisms between bacterial and archaeal RNase P in pre-tRNA cleavage. PNAS 121, e2407579121 (2024).
4. Xue, Y., Li, J., Chen, D., Zhao, X., Hong, L.* & Liu, Y.*. Observation of structural switch in nascent SAM-VI riboswitch during transcription at single-nucleotide and single-molecule resolution. Nat. Commun. 14, 2320 (2023).
5. Chien, P., Gao, L. & Liu, Y.*. Quantitative analysis of transcription termination via position-selective labeling of RNA (PLOR) method. Int. J. Mol. Sci. 24, 4934 (2023).
6. Wang, S., Chen, D., Gao, L. & Liu, Y.*. Short oligonucleotides facilitate co-transcriptional labeling of RNA at specific positions. J. Am. Chem. Soc. 144, 5494-5502 (2022).
7. Li, J., Zhang, X., Hong, L.* & Liu, Y.*. Entropy driving the Mg2+-induced folding of TPP riboswitch RNA. J. Phys. Chem. B 126, 9457-9464 (2022).
8. Xue, Y. & Liu, Y.*. Incorporation of a FRET pair into a riboswitch RNA to measure Mg2+ concentration and RNA conformational change in cell. Int. J. Mol. Sci. 23, 1493 (2022).
9. Wu, L., Chen, D., Ding, J. & Liu, Y.*. A transient conformation facilitates ligand binding to the adenine riboswitch. iScience 24, 103512 (2021).
10. Wu, L., Liu, Z.* & Liu, Y.*. Thermal adaptation of structural dynamics and regulatory function of adenine riboswitch. RNA Biol. 18, 2007-2015 (2021).
11. Zhang, X., Li, M. & Liu, Y.*. Optimization and characterization of position-selective labeling of RNA (PLOR) for diverse RNA and DNA sequences. RNA Biol. 17, 1009-1017 (2020).
12. Liu, Y., Holmstrom, E., Yu, P., Tan, K., Zuo, X., Nesbitt, D., Sousa, R., Stagno, J. & Wang, Y. Incorporation of isotopic, fluorescent, and heavy-atom-modified nucleotides into RNAs by position-selective labeling of RNA. Nat. Protoc. 13, 987-1005 (2018).
13. Liu, Y., Holmstrom, E., Zhang, J., Yu, P., Wang, J., Dyba, M., Chen, D., Ying, J., Lockett, S., Nesbitt, D., Ferré-D'Amaré, A., Sousa, R., Stagno, J. & Wang, Y. Synthesis and applications of RNAs with position-selective labelling and mosaic composition. Nature 522, 368-372 (2015).
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