长期从事合成生物学领域的应用基础研究与产业化开发工作。近年来，主持或参与国家重点研发计划、国家自然科学基金、省市级重大专项及企业横向课题等科研项目30余项。以通讯作者身份在Nature Chemistry、Nature Synthesis等高水平期刊发表论文80余篇，获授权国内外发明专利42件。研究工作聚焦功能分子的高效生物制造与创新，提出基于碳-碳键可控断裂与精准组装的定向生物合成新策略，突破了天然产物传统合成逻辑的限制，为功能分子的高效创制提供了新理论与关键技术。开发了包括聚酮合酶、甾醇降解酶在内的多酶分子机器系统，并实现了转氨酶、亚胺还原酶、醛缩酶等工业用酶的理性改造与工程应用。相关技术已在20余项工业场景中落地应用，取得显著的经济与社会效益。现任中国微生物学会微生物代谢与生物制造专业委员会副主任委员、酶工程专业委员会委员，中国生物工程学会生物催化专业委员会委员，以及《Green Synthesis and Catalysis》、《Bioresources and Bioprocessing》等期刊编委。
2023 国家技术标准创新基地（乳业）金鬲创新奖
1. Kai Jiang, Yan Gao, Yuhan Dai, Xiaoli Yan, Lu Yang, Ming Jiang, Zhi Lin, Zixin Deng, Shukun Luo, Xudong Qu. Terminal carboxyl editing drives divergence in fasmacyin and anthrabenzoxocinone biosynthesis. J. Am. Chem. Soc. 2025, 147, 26468-26476.
2. Kai Jiang, Cheng Zhu, Xiaoli Yan, Guangjun Li, Zhi Lin, Ming Jiang, Zixin Deng, Shukun Luo, Xudong Qu. A stereoselective decarboxylative aromatase/cyclase directs the biosynthesis of an axially chiral biphenyl framework in fasamycin. J. Am. Chem. Soc. 2025, 147, 5596-5601.
3. Xiaoli Yan, Xinying Jia, Zhenyao Luo, Shunjia Ji, Meng-Jie Zhang, Hui Zhang, Mingjia Yu, Julie Orts, Kai Jiang, Zhi Lin, Zixin Deng, Xu-Dong Kong, Bostjan Kobe, Yi-Lei Zhao, Mehdi Mobli, Xudong Qu. An enzymatic dual-oxa Diels-Alder reaction constructs the oxygen-bridged tricyclic acetal unit of (-)-anthrabenzoxocinones. Nat. Chem. 2025, 17, 1058-1066.
4. Yeqing Du, Guangzheng Wei, Tai-Ping Zhou, Yuhan Dai, Wenya Tian, Mancheng Tang, Zixin Deng, Binju Wang, Xudong Qu. P450-mediated dual cyclization mechanisms for pyrroloindoline unit formation in bispyrrolidinoindoline diketopiperazine alkaloid biosynthesis. J. Am. Chem. Soc. 2025, doi: 10.1021/jacs.5c14741.
5. Wenya Tian, Guangzheng Wei, Borui Duan, Haidong Peng, Huanhuan Liu, Mengmeng Zheng, Zhi Lin, Zixin Deng, Zhengyu Zhang, Xudong Qu. Unveiling bacterial cytochrome P450 enzymes that catalyze steroid side-chain cleavage. Nat. Commun. 2025, doi: 10.1038/s41467-025-67278-3.
6. Guangzheng Wei, Borui Duan, Tai-Ping Zhou, Wenya Tian, Chenghai Sun, Zhi Lin, Zixin Deng, Binju Wang, Zhengyu Zhang, Xudong Qu. A Nucleobase-driven P450 peroxidase system enables regio- and stereo-specific formation of C‒C and C‒N bonds. Proc. Natl. Acad. Sci. USA 2024, 121, e2412890121.
7. Kai Jiang, Xu Chen, Xiaoli Yan, Zixin Deng, Shunkun Luo, Xudong Qu. An unusual aromatase/cyclase programs the formation of the phenyldimethylanthrone framework in anthrabenzoxocinones and fasamycin. Proc. Natl. Acad. Sci. USA 2024, 121, e2321722121.
8. Chenghai Sun, Bao-Di Ma, Guangjun Li, Wenya Tian, Lu Yang, Haidong Peng, Zhi Lin, Zixin Deng, Xu-Dong Kong, Xudong Qu. Engineering the substrate specificity of a P450 dimerase enables the collective biosynthesis of heterodimeric tryptophan-containing diketopiperazines. Angew. Chem. Int. Ed. 2023, 62, e202304994.
9. Zhi Lin, Zhiwei Hu, Linjun Zhou, Benben Liu, Zixin Deng, Xudong Qu. A large conserved family of small molecule carboxyl methyltransferases identified from Microorganisms. Proc. Natl. Acad. Sci. USA 2023, 120, e2301389120.
10. Fuzhen Song, Mengmeng Zheng, Junlin Wang, Huanhuan Liu, Zhi Lin, Benben Liu, Zixin Deng, Hengjiang Cong, Qianghui Zhou, Xudong Qu. Chemoenzymatic synthesis of C14-functionalized steroids. Nat. Synth. 2023, 2, 729-739.
11. Mengmeng Zheng, Jun Zhang, Wan Zhang, Lu Yang, Xiaoli Yan, Wenya Tian, Zhihao Liu, Zhi Lin, Zixin Deng, Xudong Qu. An atypical acyl-CoA synthetase enables efficient biosynthesis of extender units for engineering a polyketide carbon scaffold. Angew. Chem. Int. Ed. 2022, 61, e202208734.
12. Xiaoli Yan, Jun Zhang, Hongqun Tan, Zhihao Liu, Kai Jiang, Wenya Tian, Mengmeng Zheng, Zhi Lin, Zixin Deng, Xudong Qu. A Pair of atypical KAS III homologues with initiation and elongation functions programs the polyketide biosynthesis in asukamycin. Angew. Chem. Int. Ed. 2022, 61, e202200879.
13. Chenghai Sun, Wenya Tian, Zhi Lin, Xudong Qu. Biosynthesis of pyrroloindoline-containing natural products. Nat. Prod. Rep. 2022, 39, 1721-1765.
14. Haidong Peng, Yaya Wang, Kai Jiang, Xinru Chen, Wenlu Zhang, Yanan Zhang, Zixin Deng, Xudong Qu. A dual role reductase from phytosterol catabolism enables efficient production of valuable steroid precursors. Angew. Chem. Int. Ed. 2021, 60, 5414-5420.
15. Chenghai Sun, Zhenyao Luo, Wenlu Zhang, Wenya Tian, Haidong Peng, Zhi Lin, Xiaoli Yan, Yanan Zhang, Zixin Deng, Bostjan Kobe, Xinying Jia, Xudong Qu. Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric ketopiperazines. Nat. Commun. 2020, 11, 6251.
16. Lu Yang, Jinmei Zhu, Chenghai Sun, Zixin Deng, Xudong Qu. Biosynthesis of plant tetrahydroisoquinolines alkaloids through an imine reductase route. Chem. Sci. 2020, 11, 364-371 (2019 Chemical Science HOT Article Collection).
17. Junlin Wang, Yanan Zhang, Linjun Zhou, Linpeng Wei, Wenbing Yin, Zixin Deng, Xudong Qu, Qianghui Zhou. A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids. Nat. Commun. 2019, 10, 3378.
18. Wenya Tian, Chenghai Sun, Mei Zheng, Mingjia Yu, Yanan Zhang, Haidong Peng, Dongqing Zhu, Jeffery Harmer, Zixin Deng, Shilu Chen, Mohedi Mobli, Xinying Jia, Xudong Qu. Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids. Nat. Commun. 2018, 9, 4428.
19. Yuan Li, Wan Zhang, Hui Zhang, Wenya Tian, Lian Wu, Shuwen Wang, Jun Zhang, Chenghai Sun, Yuhui Sun, Zixin Deng, Xudong Qu, Jiahai Zhou. Structural basis of a broadly selective acyltransferase from the polyketide synthase of splenocin. Angew. Chem. Int. Ed. 2018, 57, 5823-5827.
20. Chengcheng Chang, Rong Huang, Yan Yan, Hongmin Ma, Zheng Dai, Benying Zhang, Wen Liu, Zixin Deng, Xudong Qu. Uncovering the formation and selection of benzylmalonyl-CoA from the biosynthesis of splenocin and enterocin reveals a versatile way to introduce amino acids into Polyketide carbon scaffolds. J. Am. Chem. Soc. 2015, 137, 4183-4190.
21. Qiongqiong Wu, Zhuhua Wu, Xudong Qu, Wen Liu. Insights into pyrroindomycin biosynthesis reveal a uniform paradigm for tetramate/tetronate formation. J. Am. Chem. Soc. 2012, 134, 17342-17345.
22. Xudong Qu*, Bo Pang, Zicong Zhang, Ming Chen, Zhuhua Wu, Qunfei Zhao, Qinglin Zhang, Yingyan Wang, Yun Liu, Wen Liu*. Caerulomycins and collismycins share a common paradigm for 2, 2’-bipyridine biosynthesis via an unusual hybrid polyketide-peptide assembly logic. J. Am. Chem. Soc. 2012, 134, 9038-9041.
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