陶美凤
Meifeng TAO
教授
博士生导师
研究重点：
放线菌基因簇激活与天然产物挖掘的合成生物学
构建了涵盖链霉菌、拟无枝酸菌与糖多孢菌等稀有放线菌的一系列优质底盘菌株，用于异源表达来源于不同种类放线菌的沉默基因簇，获得多个结构新颖的聚酮类与非核糖体肽类生物活性天然产物。建立了微生物大片段基因组文库的高通量异源表达与功能筛选体系（LEXAS），从中发掘出新型V型羊毛硫肽合成酶基因簇及其抗MRSA活性新抗菌肽产物lexapeptide。开发了大型基因簇的人工进化高产育种技术，显著提升了纳他霉素等抗生素工业生产菌株的发酵效价。在Angewandte Chemie International Edition、Metabolic Engineering等期刊发表SCI论文50余篇，申请发明专利11项。
教育经历
Educational experience
1994-1999华中农业大学 生物化学与分子生物学专业 博士
1992 武汉大学生物化学专业 本科
工作经历
Work experience
2017-至今 上海交通大学生命科学技术学院，教授
2009-2016 上海交通大学生命科学技术学院，特别研究员
2005-2007 UW–Madison 药学院Ben Shen教授课题组，博士后
1999-2021 多次赴英国John Innes中心Keith F Chater教授课题组合作研究
1999-2008 华中农业大学生命科学技术学院，讲师/副教授
1992-1994 桂林市第二制药厂，技术员
荣誉获奖
Honours and Awards
代表性论文
Representative works
1. Weijun He, Jin Lü, Lulu Bai, Zixin Deng, Meifeng Tao*. dTSR enables efficient improvement of heterologous production of spinosad in Saccharopolyspora erythraea. Synthetic and Systems Biotechnology, 2025, 10(3): 868-875
2. Zhanzhao Cui, Xiaozheng Wang, Lixin Yin, Lu Chen, Kai Liu, Yemin Wang, Shuangjun Lin, Zixin Deng, Min Xu,* and Meifeng Tao*. Characterization of the postaglycone modifications in ristomycin biosynthesis. ACS Chemical Biology. 2025, 20(7): 1764–1774.
3. Qi Wang, Mengru Wang, Weiyuan Lyu, Xiang Li, Lei Xu, Yuyao Qin, Yan'an Ren, Zixin Deng, Meifeng Tao*, Weilie Xiao*, Feng Shen*. Rapid high‐throughput discovery of molecules with antimicrobial activity from natural products enabled by a nanoliter matrix SlipChip, Small Methods, 2025, 9(4): e2402045.
4. Lu Chen, Kai Liu, Jiali Hong, Zhanzhao Cui, Weijun He, Yemin Wang, Zixin Deng, Meifeng Tao*. The discovery of weddellamycin, a tricyclic polyene macrolactam antibiotic from an antarctic deep-sea-derived Streptomyces sp. DSS69, by heterologous expression. Marine Drugs, 2024, 22(4):189.
5. Penghui Dai, Yuyao Qin, Liyuan Li, Haidi Li, Lihuo Lv, Danying Xu, Yuqing Song, Tingting Huang, Shuangjun Lin, Zixin Deng, Meifeng Tao*. Enhancing tylosin production by combinatorial overexpression of efflux, SAM biosynthesis, and regulatory genes in hyperproducing Streptomyces xinghaiensis strain. Synthetic and Systems Biotechnology, 2023, 8(3):486-497.
6. Kai Liu, Xin-Rui Hu, Li-Xing Zhao, Yemin Wang, Zixin Deng, Meifeng Tao*. Enhancing ristomycin a production by overexpression of ParB-Like StrR family regulators controlling the biosynthesis genes. Appl Environ Microbiol , 2021, 87(19):e0106621.
7. Min Xu, Fei Zhang, Zhuo Cheng, Ghader Bashiri, Jing Wang, Jiali Hong, Yemin Wang, Lijun Xu, Xuefei Chen, Sheng-Xiong Huang, Shuangjun Lin, Zixin Deng, Meifeng Tao*. Functional genome mining reveals a class V lanthipeptide containing a D-amino acid introduced by an F420H2-dependent reductase. Angewandte Chemie International Edition, 2020, 59(41): 18029-18035.
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