肖华
Hua XIAO
教授
博士生导师
研究重点:
生命科学,转化医学,生化研究方法
肖华博士,上海交通大学教授,博导。博士毕业于中国科学院大连化学物理研究所,曾先后在加州大学洛杉矶分校和密西根大学安娜堡分校从事博士后研究。现任中国蛋白质组学专业委员会委员、中国化学会高级会员、国际细胞外囊泡学会会员。
先后主持承担科技部、国家基金委、上海市科委等科研项目以及企业横向项目,主要围绕生命科学、转化医学、生化研究方法开展基础和应用研究,研究兴趣包括蛋白质组学、修饰组学、转录组学、重大疾病诊疗靶标的发现与机制研究,在癌症细胞、微生物组、细胞外囊泡等微纳生物颗粒研究方面取得进展。先后在Research, J. Extracell. Vesicles, Mol. Cell. Proteomics, J. Med. Chem., Anal. Chem.等期刊发表论文90余篇,获授权发明专利20余项。
教育经历
Educational experience
2000-2007中国科学院大连化学物理研究所 分析化学博士学位
1996-2000安徽师范大学 化学学士学位
工作经历
Work experience
2020-至今 上海交通大学 教授
2013-2020 上海交通大学 研究员
2012-2013 美国密西根大学安娜堡分校 博士后
2008-2011 美国加州大学洛杉矶分校 博士后
2007-2008 美国加州大学欧文分校 博士后
荣誉获奖
Honours and Awards
2019 上海交通大学长聘教职
2014 科技部863青年科学家专题入选者
代表性论文
Representative works
1. Zhang, L., Wu, Y., Li, S.T., Guo, M., Zhao, J.Q., Cao, C.X., Zhang, Y., Xiao, H.*, Proteomic analysis of extracellular vesicles identifies CDCP1 as critical metastasis-related glycoprotein in lung cancer, J. Extracell. Vesicles, 2025, 14(7): e70128. https://mp.weixin.qq.com/s/lEsm57h1rjm61a3xxew0lA
2. Khan, M.I., Chen, K.E., Zhang, L., Saud, S., Zhang, Q., Xiao, H.*, Mu, Z.S.*, Cao, C.X.*, Efficient purification of exosomes and subpopulations in fresh bovine milk via fine isolation of free-flow isoelectric focusing in large scale, Chem. Eng. J., 2025, 508(10):160850
3. Wang, Z.Y., Wu, L.H., Guo, M., Zhu, J.Z., Zhao, J.Q., Wu., Y., Xiao, H.*, Zhang, Y.*, Activation of dimerized BRS3-EP3 suppresses melanoma cell migration through coupling Gαs protein, Fund. Res.-China 2024, https://doi.org/10.1016 /j.fmre.2024.04.015
4. Wang, H.Y., Zhang, Y., Wang, Z.Y., Zhang, L., Guo, M., Cao, C.X., Xiao, H.*, Deciphering Nucleic Acid Binding Proteome of Mouse Immune Organs Reveals Hub Proteins for Aging, Mol. Cell. Proteomics 2023, 22(8):100611. https://news.sjtu.edu.cn/jdzh/20230807/186926.html
5. Wu, L.H., Cui, J.H. , Zhao, C.X., Wang, Z.Y., Lu, J.H., Li, S.S., Jia, J.P., Xiao, H.*, Zhang, Y.*, Discovery of Dimethyl Shikonin Oxime 5a, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Type 2 Diabetes Mellitus, J. Med. Chem. 2023, 66(12):8011-8029. http://news.sjtu.edu.cn/jdzh/20230616/184772.html
6. Jiang, X.T., Zhang, Y., Wang, H.Y., Wang, Z.Y., Hu, S.*, Cao, C.X.*, Xiao, H.*, In-Depth Metaproteomics Analysis of Oral Microbiome for Lung Cancer. Research. 2022, 2022: 9781578. https://news.sjtu.edu.cn/jdzh/20221019/175290.html
7. Wang, Z.Y. , Wu, L.H. , Wang, H.Y., Zhang, Y.*, Xiao, H.*, Agonist-Induced Extracellular Vesicles Contribute to the Transfer of Functional Bombesin Receptor-Subtype 3 to Recipient Cells. Cell. Mol. Life Sci. 2022, 79:72. https://news.sjtu.edu.cn/jdzh/20220119/166908.html
8. Zhang, B.H. , Guo, M. , Wang, H.Y. , Wang, Z.Y., Zhang, L., Zhang, Y., Cao, C.X., Xiao, H.*, Metal Organic Framework Nanomaterial-Based Extraction and Proteome Analysis of Membrane and Membrane-Associated Proteins. Anal. Chem. 2021, 93(48):15922-15930.
9. Jiang, X.T. , Liu, S. , Zhang, Y. , Ji, Y., Sohail, A., Cao, C.X.*, Wang, P.*, Xiao, H.*, Free-Flow Isoelectric Focusing for Comprehensive Separation and Analysis of Human Salivary Microbiome for Lung Cancer. Anal. Chem. 2020, 92(17):12017-12025. https://news.sjtu.edu.cn/jdzh/20200825/129547.html
10. Qiao, Z. , Zhang, Y. , Ge, M.L. , Liu, S., Jiang, X.T., Shang, Z., Liu, H., Cao, C.X., Xiao, H.*, Cancer cell derived small extracellular vesicles contribute to recipient cell metastasis through promoting HGF/c-Met pathway. Mol. Cell. Proteomics 2019, 18 (8):1619-1629. https://news.sjtu.edu.cn/jdzh/20190702/106381.html