徐俊
XU Jun
教授
博士生导师
研究重点：
（1）红树林链霉菌天然产物生物合成机制；（2）深海超嗜热古菌环境适应性机理；（3）海洋微生物生态学
一直从事微生物学相关教学科研工作，主持完成国家自然科学基金、国家863项目、中国大洋专项、国家973项目等多项课题。主要研究成果包括：（1）鉴定和描述了多个海洋微生物新种，包括具有天然精简基因组的厦门链霉菌（Streptomyces xiamenensis）；（2）解析了抗纤维化活性化合物厦门霉素的生物合成途径，构建了高产该化合物的生物合成体系；（3）构建了深海嗜压超嗜热古菌Pyroccous yayanosii的遗传操作体系；（4）表征了和改造了一批可控制此类古菌基因表达的启动子和核糖体结合位点，为超嗜热古菌的合成生物学研究提供了丰富的基因元件;（5）研究了与P. yayanosii温度适应性相关的两个RNA分子伴侣的功能。解析了在深海超嗜热古菌中调控高静水压诱导基因表达的转录激活蛋白的分子机制。
教育经历
Educational experience
2000.04–2003.03 筑波大学, 应用生物化学, 博士;
1994.09–1997.06 华中农业大学, 微生物学, 硕士;
1990.09–1994.06 华中农业大学, 微生物学, 学士。
工作经历
Work experience
2009.03-至今: 上海交通大学生命科学技术学院, 微生物代谢国家重点实验室, 教授
2005.05-2009.02: 国家海洋局三所, 海洋生物资源重点实验室, 副研究员
1997.08-2005.04: 北京生物医药研究所, 抗生素研究室, 助理研究员
2003.04-2004.03: 日本国立食品综合研究所, 博士后
荣誉获奖
Honours and Awards
代表性论文
Representative works
1. Zhang H, Gao Z, Li C, Xu J. 2025. Two Cold-Shock Proteins Characterised as RNA Chaperone of Hyperthermophilic Archaeon Pyrococcus yayanosii. Environmental Microbiology 27:e70105.
2. Li C, Xu J. 2025. Construction of Promoter-Ribosome Binding Site Library for Manipulating Gene Expression in the Hyperthermophilic Archaeon Thermococcus kodakarensis. ACS Synthetic Biology 14:2181-2197.
3. Li C, Li SY, Song QH, Da LT, Xu J. 2025. High hydrostatic pressure promotes gene transcription via a cystathionine-β-synthase domain-containing protein in the hyperthermophilic archaeon Pyrococcus yayanosii. Nucleic Acids Research 53:gkae1289.
4. Lu Y, Lv Y, Zhang Y, Liu Q, Xu X, Xiao X, Xu J. 2023. Metatranscriptomes reveal the diverse responses of Thaumarchaeota ecotypes to environmental variations in the northern slope of the South China Sea. Environmental Microbiology 25:410-427.
5. Lu Y, Zhang Y, Wang J, Zhang M, Wu Y, Xiao X, Xu J. 2022. Dynamics in Bacterial Community Affected by Mesoscale Eddies in the Northern Slope of the South China Sea. Microbial Ecology 83:823-836.
6. Zhou T, Gao D, Li JX, Xu MJ, Xu J. 2021. Identification of an α-Oxoamine Synthase and a One-Pot Two-Step Enzymatic Synthesis of α-Amino Ketones. Org Lett 23:37-41.
7. Bu XL, Weng JY, He-Lin Y, Xu MJ, Xu J. 2020. Three transcriptional regulators positively regulate the biosynthesis of polycyclic tetramate macrolactams in Streptomyces xiamenensis 318. Appl Microbiol Biotechnol 104:701-711.
8. Song QH, Li Z, Chen RK, Ma XP, Xiao X, Xu J. 2019. Induction of a Toxin-Antitoxin Gene Cassette under High Hydrostatic Pressure Enables Markerless Gene Disruption in the Hyperthermophilic Archaeon Pyrococcus yayanosii. Applied and Environmental Microbiology 85.
9. He B-B, Zhou T, Bu X-L, Weng J-Y, Xu J, Lin S, Zheng J-T, Zhao Y-L, Xu M-J. 2019. Enzymatic Pyran Formation Involved in Xiamenmycin Biosynthesis. ACS Catalysis doi:10.1021/acscatal.9b01034:5391-5399.
10. Li Z, Li X, Xiao X, Xu J. 2016. An Integrative Genomic Island Affects the Adaptations of the Piezophilic Hyperthermophilic Archaeon Pyrococcus yayanosii to High Temperature and High Hydrostatic Pressure. Front Microbiol 7:1927.
11. Xu MJ, Wang JH, Bu XL, Yu HL, Li P, Ou HY, He Y, Xu FD, Hu XY, Zhu XM, Ao P, Xu J. 2016. Deciphering the streamlined genome of Streptomyces xiamenensis 318 as the producer of the anti-fibrotic drug candidate xiamenmycin. Sci Rep 6:18977.
12. Li X, Fu L, Li Z, Ma X, Xiao X, Xu J. 2015. Genetic tools for the piezophilic hyperthermophilic archaeon Pyrococcus yayanosii. Extremophiles 19:59-67.
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