杨广宇
Guangyu Yang
研究员
博士生导师
研究重点：
重要代谢酶类的定向进化及其在生物医药领域的应用
杨广宇研究员专注于酶工程的新技术方法开发、酶定向进化、体外合成生物学等研究，特别关注于具有重要产业应用价值的脂类、糖类、核酸等代谢酶类的研究，近年来在Science Adv., Nat. Commun., Angew. Chemie., J. Am. Chem. Soc.,等著名学术期刊上发表论文60余篇，授权发明专利30余项。获上海市科学技术奖一等奖，中国发明创业奖人物奖等荣誉。2015年创立武汉瀚海新酶生物科技有限公司，产品出口到海外25个国家与地区，服务超过2000余家国内外生物医药、疫苗制备、体外诊断试剂生产厂家。
教育经历
Educational experience
2012.03 2013.06 不列颠哥伦比亚大学 生物化学 博士后
2003.09 2009.06 吉林大学 生物化学 硕博连读
1999.09 2003.06 吉林大学 生物化学 本科
工作经历
Work experience
2018.01-至今 上海交通大学生命科学技术学院 研究员
2013.01-2017.12上海交通大学生命科学技术学院 副研究员
2009.07-2012.12 上海交通大学生命科学技术学院 讲师
荣誉获奖
Honours and Awards
2024年 中国商业联合会科技创新人物奖
2023年 中国发明创业人物奖
2022年 上海市技术发明一等奖（第二获奖人）
2019年“东富龙”生物工程青年科学家奖
2015年 上海交通大学“青年岗位能手”
代表性论文
Representative works
1. T Nie, Z Yan, H Liu, X Zhang, W Zhong, Q Chen, C Zhu, L Hong, G Yang. Protein language model-assisted directed evolution of cyclodextrinase Enables Precision α-O-Oligosaccharide synthesis. Bioresource Technology, 133206
2. T Han, W Zhu, R Xu, ST Chiang, X Jin, X Shen, C Qian, G Yang, R Li, X Ai. Glycan-Modified Cellular Nanosponges for Enhanced Treatment of Cholera Toxin-Induced Secretory Diarrhea. J. Am. Chem. Soc., 147 (20), 16982-16991
3. Jiahao Bian, Pan Tan, Ting Nie, Liang Hong, Guang-Yu Yang*.Insight into High-order Epistasis and Efficiently Combining Multiple Mutations to Enhance Enzyme Thermostability Using Temperature-Guided Protein Language Model. mLife, 2024, 3(4):492–504. IF=4.5
4. Xuefeng Jin, Hanchao Cheng, Xiaohui Chen, Xuefeng Cao, Cong Xiao, Fengling Ding, Huirong Qu, Peng George Wang, Yan Feng, Guang-Yu Yang*. A modular chemo-enzymatic cascade strategy for the structure-customized assembly of ganglioside analogues: unveiling biological activities and identifying drug ingredients. Communications Chemistry. 2024,
5. Bo He, Yating Zhang, Huaping Liu, Manuel Tang, Ke Yang, Silian Cheng, Jie Shen, Yongzhen Wei, Weiliang Deng, Qiang Zhao*, Guang-Yu Yang*. An Endocellulase-Triggered NO Targeted-Release Enzyme-Prodrug Therapy System and Its Application in Ischemia Injury. Adv Healthc Mater. 2024:e2401599.
6. Juntao Wang, Dan Lu, Ran Sun, Shuwen Lei, Shuhua Luo, Xin Dang, Yang Zhang, Chang Yuan, Yong Zhang, Jinhong Wu, Guangyu Yang*, Lei Fu*, Faqin Jiang*. One-Pot Enzymatic Synthesis and Biological Evaluation of Ganglioside GM3 Derivatives as Potential Cancer Immunotherapeutics. Journal of Medicinal Chemistry. 2022, 65 (3), 1883-1897
7. B He, X Bai, Y Tan, W Xie, Y Feng, GY Yang*. Glycosyltransferases: Mining, engineering and applications in biosynthesis of glycosylated plant natural products. Synthetic and Systems Biotechnology. 2022, 7 (1), 602-620
8. Xi Deng, Liuqing Chen, Mohan Hei, Tiangang Liu, Yan Feng, Guang-Yu Yang*. Structure-guided Reshaping of the Acyl Binding Pocket of 'TesA Thioesterase Enhances Octanoic Acid Production in E. Coli, Metab Eng. 2020, 61:24-32.
9. Yumeng Tan, Yong Zhang, Yunbin Han, Hao Liu, Haifeng Chen, Fuqiang Ma, Stephen G Withers, Yan Feng, Guangyu Yang*. Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method. Science Advances, 2019, eaaw8451
10. Fuqiang Ma#, Meng Ting Chung#, Yuan Yao, Robert Nidet, Lap Man Lee, Allen P. Liu, Yan Feng, Katsuo Kurabayashi*, Guang-Yu Yang*. Efficient molecular evolution to generate enantioselective enzymes using a dual-channel microfluidic droplet screening platform. Nature Communications, 2018, 9:1030.
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