姚瑞莲
ruilian Yao
副研究员
硕士生导师
研究重点:
代谢流量组学
长期从事13C代谢流量分析工作,指导合成生物学的改造和临床前药代动力学研究,并与头部高新技术企业合作多个项目,推动该技术在转化医学和新药研发领域的应用。承担国家自然科学基金青年基金、科技部重点研发计划子课题。发表SCI论文(包括Developmental Cell, Journal of Agricultural and Food Chemistry和Biotechnology for Biofuels等)多篇,获批软件著作权2项。
教育经历
Educational experience
2011.10-2013.09 九州工业大学 信息工学 博士
2002.09-2006.07 华东理工大学 应用物理 学士
工作经历
Work experience
2020.12-至今 上海交通大学,生命科学技术学院,副研究员
2017.12-2020.12 上海交通大学,生命科学技术学院,助理研究员
2013.10-2017.11 上海交通大学,生命科学技术学院,博士后
2010.02-2011.09 九州工业大学, 信息科学和系统工程学院,生命科学和生物信息学系, 产学官连携研究员
荣誉获奖
Honours and Awards
代表性论文
Representative works
1. Ying Cao#, Ruolan Qian#, Ruilian Yao#, Quan Zheng#, Chen Yang, Xupeng Yang, Shuyi Ji, Linmen Zhang, Shujie Zhan, Yiping Wang, Tianshi Wang, Hui Wang, Chun-Ming Wong, Shengxian Yuan, Christopher Heeschen, Qiang Gao René Bernards*, Wenxin Qin*, Cun Wang*. Developmental Cell, 2025, 60, 1-15.
2. Ruilian Yao, Peisheng Lu, Yiling Liu, Hongbo Hu, Haihan Zhang, Xuehong Zhang*. Fluxomic, metabolomic, and transcriptomic analyses reveal metabolic responses to phenazine-1-carboxamide synthesized in Pseudomonas chlororaphis. Journal of Agricultural and Food Chemistry, 2024, 72, 23928-23936.
3. 姚瑞莲,13C 代谢流量分析发展 30 年,生物工程学报,2021, 37(5): 1510-1525。
4. Ruilian Yao, Jiawei Li, Lei Feng, Xuehong Zhang, Hongbo Hu*. 13C metabolic flux analysis-guided metabolic engineering of Escherichia coli for improved acetol production from glycerol. Biotechnology for Biofuels, 2019, 12:29.
5. Ruilian Yao#, Di Liu#, Xiao Jia, Yuan Zheng, Wei Liu, Yi Xiao*. CRISPR-Cas9/Cas12a biotechnology and application in bacteria. Synthetic and Systems Biotechnology, 2018, 3(3): 135-149.
6. Ruilian Yao, Keli Pan, Huasong Peng, Lei Feng, Hongbo Hu, Xuehong Zhang*. Engineering and systems-level analysis of Pseudomonas chlororaphis for production of phenazine-1-carboxamide using glycerol as the cost-effective carbon source. Biotechnology for Biofuels, 2018, 11:130.
7. Ruilian Yao, Dewang Xiong, Hongbo Hu, Masataka Wakayama, Wenjuan Yu, Xuehong Zhang*, Kazuyuki Shimizu*. Elucidation of the co-metabolism of glycerol and glucose in Escherichia coli by genetic engineering, transcription, profiling, and 13C metabolic flux analysis. Biotechnology for Biofuels, 2016, 9:175.