张晨虹
Chenhong Zhang
研究员
硕士生导师
研究重点：
肠道菌群与慢性疾病
在生态系统理论指导下，通过不依赖于分类地位和数据库的方法，解析菌株网落中的稳定关系，在广泛人群中发现了维持宿主健康的核心菌群，其特征为构成相互竞争的两个功能群；揭示了特定菌通过产生代谢物或易位，调控远端器官免疫，影响疾病发生发展的机制；通过设计膳食纤维组合或菌群移植等手段恢复肠道核心菌群特征，改善了临床上无有效治疗手段的糖尿病周围神经病变、非酒精性脂肪肝等。以第一作者或通讯作者在国际上具有影响力的杂志Science、Cell、Cell Metabolism、 Nature communications、Microbiome、ISME Journal等发表论文。2022-2024连续三年入选科睿唯安 “全球高被引科学家”。 担任中国微生物学会微生物组专业委员会委员、中国生物物理学会肠道菌群分会委员、上海市微生物学会基础微生物专业委员会委员、上海市预防医学会微生态专业委员会委员等。
教育经历
Educational experience
2005.09-2011.03 上海交通大学, 微生物学, 博士
2001.09-2005.06 上海交通大学, 生物技术, 学士
工作经历
Work experience
2019.07-至今 上海交通大学, 生命科学技术学院, 研究员
2017.01-2019.06 上海交通大学, 生命科学技术学院, 副研究员
2013.10-2016.12 上海交通大学, 生命科学技术学院, 助理研究员
2011.06-2013.09 法国农业科学研究院, 博士后
荣誉获奖
Honours and Awards
河南省科学技术进步奖一等奖（2/15）
代表性论文
Representative works
1. Xiaotong Lin, Chaoxun Wang, Biao Liu, Yin Zhu, Rui Zhai, Chenhong Zhang*. “Temporal response patterns of human gut microbiota to dietary fiber. iMeta 2025: e70046. https://doi.org/10.1002/imt70046.
2. Teng Teng, Fang Huang, Ming Xu, Xuemei Li, Lige Zhang, Bangmin Yin, Yuping Cai, Fei Chen, Luman Zhang, Jushuang Zhang, Aoyi Geng, Chengzhi Chen, Xiaofei Yu, Jing Sui, Zheng Jiang Zhu, Kai Guo, Chenhong Zhang*, Xinyu Zhou*; Microbiota alterations leading to amino acid deficiency contribute to depression in children and adolescents. Microbiome 2025, 13:128.
3. Han Pan, Delei Song, Zhiyi Wang, Xin Yang, Pei Luo, Wei Li, Yan Li, Mengxue Gong, Chenhong Zhang*; Dietary modulation of gut microbiota affects susceptibility to drug-induced liver injury, Gut Microbes, 2024, 16(1): 2439534
4. Guojun Wu, Ting Xu, Naisi Zhao, Yan Y. Lam, Xiaoying Ding, Dongqin Wei, Jian Fan, Yajuan Shi, Xiaofeng Li, Mi Li, Shenjie Ji, Xuejiao Wang, Huaqing Fu, Feng Zhang, Yu Shi*, Chenhong Zhang*，Yongde Peng*, Liping Zhao*; A core microbiome signature as an indicator of health, Cell, 2024 187(23):6550-6565
5. Junpeng Yang; Xueli Yang; Guojun Wu; Fenglian Huang; Xiaoyang Shi; Wei Wei; Yingchao Zhang; Haihui Zhang; Lina Cheng; Lu Yu; Jing Shang; Yinghua Lv; Xiaobing Wang; Rui Zhai; Pan Li; Bota Cui; Yuanyuan Fang; Xinru Deng; Shasha Tang; Limin Wang; Qian Yuan; Liping Zhao*; Faming Zhang*, Chenhong Zhang*, Huijuan Yuan* ; Gut microbiota modulate distal symmetric polyneuropathy in patients with diabetes, Cell Metabolism, 2023, 35(9): 1548-1562
6. Xin Yang, Zhiyi Wang, Junling Niu, Rui Zhai, Xinhe Xue, Guojun Wu, Yuanyuan Fang, Guangxun Meng, Huijuan Yuan, Liping Zhao*, Chenhong Zhang*, Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice. Microbiome, 2023, 11:62
7. Junling Niu, Mengmeng Cui, Xin Yang, Juan Li, Yuhui Yao, Qiuhong Guo, Ailing Lu, Xiaopeng Qi, Dongming Zhou, Chenhong Zhang*, Liping Zhao*, Guangxun Meng*, Microbiota-derived acetate enhances host antiviral response via NLRP3. Nature Communications, 2023, 14:642
8. Runtan Cheng, Lu Wang, Shenglong Le, Yifan Yang, Can Zhao, Xiangqi Zhang, Xin Yang , Ting Xu, Leiting Xu, Petri Wiklund, Jun Ge, Dajiang Lu, Chenhong Zhang*, Luonan Chen*, Sulin Cheng*; A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease. Nature Communications, 2022, 13:2555
9. H. Liu, X. Chen, X. Hu, H. Niu, R. Tian, H. Wang, H. Pang, L. Jiang, B. Qiu, X. Chen, Y. Zhang, Y.i Ma, S. Tang, H. Li, S. Feng, S. Zhang*, Chenhong Zhang*, Alterations in the gut microbiome and metabolism with coronary artery disease severity, Microbiome, (2019) 7:68
10. Liping Zhao#*, Feng Zhang#, Xiaoying Ding#, Guojun Wu#, Yan Y. Lam#, Xuejiao Wang, Huaqing Fu, Xinhe Xue, Chunhua Lu, Jilin Ma, Lihua Yu,Chengmei Xu, Zhongying Ren, Ying Xu, Songmei Xu, Hongli Shen, Xiuli Zhu, Yu Shi, Qingyun Shen, Weiping Dong, Rui Liu, Yunxia Ling, Yue Zeng, Xingpeng Wang, Qianpeng Zhang, Jing Wang, Linghua Wang, Yanqiu Wu, Benhua Zeng, Hong Wei, Menghui Zhang, Yongde Peng*, Chenhong Zhang*, Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes, Science. 2018, 359: 1151-1156.
11. Pan F, Zhang L, Li M, Hu Y, Zeng B, Yuan H, Zhao L, Zhang C*. Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice. Microbiome.2018;6(1):54.
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