张梦晖
Menghui Zhang
副研究员
硕士生导师
研究重点：
人体微生物与人体健康的生物信息挖掘
张梦晖，比利时布鲁塞尔自由大学药学博士，上海交通大学微生物科学系副研究员。主要从事复杂生物体系信息挖掘的方法学研究及应用，将多变量统计与生物信息学结合，开发适用于微生物生态学领域（特别是人体微生物与人体健康）大数据的信息挖掘方法。承担/参与了国家科技部 863、973、国家自然基金重点及面上等多项项目。在食品、石油及日化等领域与多家企业有项目合作。在Science、PNAS、 Nat Commun、 The ISME journal、mBio等杂志发表文章共72篇， 其中有 ESI高被引8篇， 2篇分别于2008年、2012年度评为中国百篇最具国际影响力学术论文。申请专利6项，其中2项授权，3项公开。软件著作权2项。
教育经历
Educational experience
2001.07-2005.03 比利时布鲁塞尔自由大学, 药学博士(化学计量学)
1999.09-2001.06 比利时布鲁塞尔自由大学, 药学硕士（医学与药学研究）
1986.09-1990.06 中国药科大学, 药学学士（药理）
工作经历
Work experience
2005.11-至今 上海交通大学, 生命科学技术学院, 讲师、副研究员
1998.04-1999.03 日本富山医科药科大学, 和汉药研究所, 客员研究员
1990.07-2005.09 湖南省药品检验研究所, 生化药理室, 药师
荣誉获奖
Honours and Awards
代表性论文
Representative works
1、 Xu, Z., Yang, F., Xiang, B., Chang, X., Xia, D., Wu, Y., Zhang, Y., Zhang, M., 2025. Abnormal microbial amino acid metabolism and activated pathogenesis in scalp with dandruff. Journal of Investigative Dermatology, 145:1823-1826
2、 Xiang, B., Zhao, L., Zhang, M. 2023. Unitig level assembly graph based metagenome-assembled genome refiner (UGMAGrefiner): A tool to increase completeness and resolution of metagenome-assembled genomes. Computational and Structural Biotechnology Journal，21:2394-2404
3、 Tan, Y., Du, H., Zhang, H., Fang, C., Jin, G., Chen, S., Wu, Q., Zhang, Y., Zhang, M., & Xu, Y. 2022. Geographically Associated Fungus-Bacterium Interactions Contribute to the Formation of Geography-Dependent Flavor during High-Complexity Spontaneous Fermentation. Microbiol Spectr, 10(5): e0184422.
4、 Xiang, B., Zhao, L., Zhang, M. 2021. Metagenome-scale metabolic network suggested folate produced by Bifidobacterium longum might contribute to high-fiber diet induced weight loss in a Prader-Willi syndrome child. Microorganisms，9:2493
5、 Li,H., WU,G., ZHAO, L. & ZHANG, M..2021.Suppressed inflammation in obese children by high-fiber diet is associated with attenuation of gut microbial virulence factor genes Virulence. Virulence, 12(1), 1754-1770
6、 Zhao, L., Zhang, F., Ding, X., Wu, G., LAM, Y. Y., Wang, X., Fu, H., Xue, X., Lu, C., Ma, J., Yu, L., Xu, C., Ren, Z., Xu, Y., Xu, S., Shen, H., Zhu, X., Shi, Y., Shen, Q., Dong, W., Liu, R., Ling, Y., Zeng, Y., Zhang, Q., Wang, J., Wang, L., Wu, Y., Zeng, B., Wei, H., Zhang, M., Peng, Y. & Zhang, C. 2018. Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Science, 359, 1151-1156.
7、 GUOJUN WU, CHENHONG ZHANG, HUAN WU, RUIRUI WANG, JIAN SHEN, LINGHUA WANG, YUFENG ZHAO, XIAOYAN PANG, XIAOJUN ZHANG, LIPING ZHAO & ZHANG, M. 2017. Genomic microdiversity of Bifidobacterium pseudocatenulatum underlying differential strain-level responses to dietary carbohydrate intervention. mBio, 8, e02348-16.
8、 XU, Z., WANG, Z., YUAN, C., LIU, X., YANG, F., WANG, T., WANG, J., MANABE, K., QIN, O., WANG, X., ZHANG, Y. & ZHANG, M. 2016. Dandruff is associated with the conjoined interactions between host and microorganisms. Sci Rep, 6, 24877.
9、 ZHANG, J., GUO, Z., XUE, Z., SUN, Z., ZHANG, M., WANG, L., WANG, G., WANG, F., XU, J., CAO, H., XU, H., LV, Q., ZHONG, Z., CHEN, Y., QIMUGE, S., MENGHE, B., ZHENG, Y., ZHAO, L., CHEN, W. & ZHANG, H. 2015. A phylo-functional core of gut microbiota in healthy young Chinese cohorts across lifestyles, geography and ethnicities. The ISME journal, 9, 1979-90.
10、 ZHANG, M., ZHANG, M., ZHANG, C., DU, H., WEI, G., PANG, X., ZHOU, H., LIU, B. & ZHAO, L. 2009. Pattern extraction of structural responses of gut microbiota to rotavirus infection via multivariate statistical analysis of clone library data. FEMS Microbiol Ecol, 70, 21-9.
11、 LI, M., WANG, B., ZHANG, M., RANTALAINEN, M., WANG, S., ZHOU, H., ZHANG, Y., SHEN, J., PANG, X., WEI, H., CHEN, Y., LU, H., ZUO, J., SU, M., QIU, Y., JIA, W., XIAO, C., SMITH, L. M., YANG, S., HOLMES, E., TANG, H., ZHAO, G., NICHOLSON, J. K., LI, L. & ZHAO, L. 2008. Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A, 105, 2117-22.
12、 ZHANG, M. H., XU, Q. S. & MASSART, D. L. 2005. Boosting Partial Least Squares. Anal. Chem., 77, 8.
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