报告摘要/Abstract

The Natural Products Discovery Center (NPDC) at The Herbert Wertheim UF Scripps Institute for Biomedical Research & Innovation houses one of the world’s largest actinobacterial strain collections and genome databases.The Actinobacterial Strain Collection, containing 122,523 strains and isolated over the last eight decades and from 77 different countries, represents microbial and natural product (NP) diversities that are not available anywhere else.The Actinobacterial Genome Database, containing 11,357 sequenced and curated genomes and growing at the rate of ~10,000 genomes/year, represents the largest Actinobacterial Genome Database with the sequenced strains publicly available.  We have launched an interactive NPDC web portal as the prototype of the Actinobacterial Strain Collection and Genome Database National Resource (https://npdc.rc.ufl.edu/home), consisting of (i) the Strain Collection, (ii) the Genome Database, and (iii) the Bioinformatics Interface. Lessons learned from our NPs program over the years and preliminary analysis of the Actinobacterial Strain Collection and Genome Database at NPDC will be presented to highlight how such a National Resource could radically transform the current paradigm of NPs research and drug discovery.

个人简介/Brief Bio

Ben Shen

Department of Chemistry，Department of Molecular Medicine

University of Florida 

Fellow of American Academy of Microbiology

Fellow of American Association for the Advancement of Science

Fellow of American Society of Pharmacognosy

Prof. Ben Shen received B.Sc. from Hangzhou University, M.S. from the Chinese Academy of Sciences, Ph.D. from Oregon State University, and carried out postdoctoral research at University of Wisconsin-Madison. Prof. Shen served on the faculty at the University of California, Davis, University of Wisconsin-Madison, and The Scripps Research Institute, Scripps Research. Currently, Ben is a Professor in the Departments of Chemistry and Molecular Medicine, serves as Director of Natural Products Discovery Center at the Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, and is a Professor in the Skaggs Graduate School of Chemical and Biological Sciences at Scripps Research.  Research in the Shen Lab centers on chemistry, biochemistry, and genetics of natural product biosynthesis and mining of actinobacterial genomes for natural products and drug discovery.